Noninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway

Abstract Spatiotemporal signal transmission in the human subcortical visual pathway has not been directly demonstrated to date. To delineate this signal transmission noninvasively, we investigated the early latency components between 45 ms (P45m) and 75 ms (N75m) of visually-evoked neuromagnetic fie...

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Autores principales:	Fumiaki Yoshida, Masayuki Hirata, Ayako Onodera, Tetsu Goto, Hisato Sugata, Shiro Yorifuji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/98cf1ced0b5848b98675a34870d985ee
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spelling	oai:doaj.org-article:98cf1ced0b5848b98675a34870d985ee2021-12-02T16:06:40ZNoninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway10.1038/s41598-017-04700-x2045-2322https://doaj.org/article/98cf1ced0b5848b98675a34870d985ee2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04700-xhttps://doaj.org/toc/2045-2322Abstract Spatiotemporal signal transmission in the human subcortical visual pathway has not been directly demonstrated to date. To delineate this signal transmission noninvasively, we investigated the early latency components between 45 ms (P45m) and 75 ms (N75m) of visually-evoked neuromagnetic fields (VEFs). Four healthy volunteers participated in this study. Hemi-visual field light flash stimuli were delivered a total of 1200 times. Neuromagnetic responses were measured with a 160-channel whole-head gradiometer. In three participants, averaged waveforms indicated a subtle but distinct component that peaked with a very early latency at 44.7 ± 2.1 ms with an initial rise latency of 36.8 ± 3.1 ms, followed by a typical prominent cortical component at 75 ms. The moving equivalent current dipoles continuously estimated from P45m to N75m were first localized in the vicinity of the contralateral lateral geniculate body, then rapidly propagated along the optic radiation and finally terminated in the contralateral calcarine fissure. This result indicates that the source of P45m is the lateral geniculate body and that the early latency components P45m–N75m of the VEFs reflect neural transmission in the optic radiation. This is the first report to noninvasively demonstrate the neurophysiological transmission of visual information through the optic radiation.Fumiaki YoshidaMasayuki HirataAyako OnoderaTetsu GotoHisato SugataShiro YorifujiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fumiaki Yoshida Masayuki Hirata Ayako Onodera Tetsu Goto Hisato Sugata Shiro Yorifuji Noninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway
description	Abstract Spatiotemporal signal transmission in the human subcortical visual pathway has not been directly demonstrated to date. To delineate this signal transmission noninvasively, we investigated the early latency components between 45 ms (P45m) and 75 ms (N75m) of visually-evoked neuromagnetic fields (VEFs). Four healthy volunteers participated in this study. Hemi-visual field light flash stimuli were delivered a total of 1200 times. Neuromagnetic responses were measured with a 160-channel whole-head gradiometer. In three participants, averaged waveforms indicated a subtle but distinct component that peaked with a very early latency at 44.7 ± 2.1 ms with an initial rise latency of 36.8 ± 3.1 ms, followed by a typical prominent cortical component at 75 ms. The moving equivalent current dipoles continuously estimated from P45m to N75m were first localized in the vicinity of the contralateral lateral geniculate body, then rapidly propagated along the optic radiation and finally terminated in the contralateral calcarine fissure. This result indicates that the source of P45m is the lateral geniculate body and that the early latency components P45m–N75m of the VEFs reflect neural transmission in the optic radiation. This is the first report to noninvasively demonstrate the neurophysiological transmission of visual information through the optic radiation.
format	article
author	Fumiaki Yoshida Masayuki Hirata Ayako Onodera Tetsu Goto Hisato Sugata Shiro Yorifuji
author_facet	Fumiaki Yoshida Masayuki Hirata Ayako Onodera Tetsu Goto Hisato Sugata Shiro Yorifuji
author_sort	Fumiaki Yoshida
title	Noninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway
title_short	Noninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway
title_full	Noninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway
title_fullStr	Noninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway
title_full_unstemmed	Noninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway
title_sort	noninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/98cf1ced0b5848b98675a34870d985ee
work_keys_str_mv	AT fumiakiyoshida noninvasivespatiotemporalimagingofneuraltransmissioninthesubcorticalvisualpathway AT masayukihirata noninvasivespatiotemporalimagingofneuraltransmissioninthesubcorticalvisualpathway AT ayakoonodera noninvasivespatiotemporalimagingofneuraltransmissioninthesubcorticalvisualpathway AT tetsugoto noninvasivespatiotemporalimagingofneuraltransmissioninthesubcorticalvisualpathway AT hisatosugata noninvasivespatiotemporalimagingofneuraltransmissioninthesubcorticalvisualpathway AT shiroyorifuji noninvasivespatiotemporalimagingofneuraltransmissioninthesubcorticalvisualpathway
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Noninvasive spatiotemporal imaging of neural transmission in the subcortical visual pathway

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