Dengue infection in children in Ratchaburi, Thailand: a cohort study. I. Epidemiology of symptomatic acute dengue infection in children, 2006-2009.

<h4>Background</h4>There is an urgent need to field test dengue vaccines to determine their role in the control of the disease. Our aims were to study dengue epidemiology and prepare the site for a dengue vaccine efficacy trial.<h4>Methods and findings</h4>We performed a pros...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Arunee Sabchareon, Chukiat Sirivichayakul, Kriengsak Limkittikul, Pornthep Chanthavanich, Saravudh Suvannadabba, Vithaya Jiwariyavej, Wut Dulyachai, Krisana Pengsaa, Harold S Margolis, G William Letson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/98cf6a615b1945b19fdfd6dd73762c07
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:98cf6a615b1945b19fdfd6dd73762c07
record_format	dspace
spelling	oai:doaj.org-article:98cf6a615b1945b19fdfd6dd73762c072021-11-18T09:13:58ZDengue infection in children in Ratchaburi, Thailand: a cohort study. I. Epidemiology of symptomatic acute dengue infection in children, 2006-2009.1935-27271935-273510.1371/journal.pntd.0001732https://doaj.org/article/98cf6a615b1945b19fdfd6dd73762c072012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22860141/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735<h4>Background</h4>There is an urgent need to field test dengue vaccines to determine their role in the control of the disease. Our aims were to study dengue epidemiology and prepare the site for a dengue vaccine efficacy trial.<h4>Methods and findings</h4>We performed a prospective cohort study of children in primary schools in central Thailand from 2006 through 2009. We assessed the epidemiology of dengue by active fever surveillance for acute febrile illness as detected by school absenteeism and telephone contact of parents, and dengue diagnostic testing. Dengue accounted for 394 (6.74%) of the 5,842 febrile cases identified in 2882, 3104, 2717 and 2312 student person-years over the four years, respectively. Dengue incidence was 1.77% in 2006, 3.58% in 2007, 5.74% in 2008 and 3.29% in 2009. Mean dengue incidence over the 4 years was 3.6%. Dengue virus (DENV) types were determined in 333 (84.5%) of positive specimens; DENV serotype 1 (DENV-1) was the most common (43%), followed by DENV-2 (29%), DENV-3 (20%) and DENV-4 (8%). Disease severity ranged from dengue hemorrhagic fever (DHF) in 42 (10.5%) cases, dengue fever (DF) in 142 (35.5%) cases and undifferentiated fever (UF) in 210 (52.5%) cases. All four DENV serotypes were involved in all disease severity. A majority of cases had secondary DENV infection, 95% in DHF, 88.7% in DF and 81.9% in UF. Two DHF (0.5%) cases had primary DENV-3 infection.<h4>Conclusion</h4>The results illustrate the high incidence of dengue with all four DENV serotypes in primary school children, with approximately 50% of disease manifesting as mild clinical symptoms of UF, not meeting the 1997 WHO criteria for dengue. Severe disease (DHF) occurred in one tenth of cases. Data of this type are required for clinical trials to evaluate the efficacy of dengue vaccines in large scale clinical trials.Arunee SabchareonChukiat SirivichayakulKriengsak LimkittikulPornthep ChanthavanichSaravudh SuvannadabbaVithaya JiwariyavejWut DulyachaiKrisana PengsaaHarold S MargolisG William LetsonPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 6, Iss 7, p e1732 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Arunee Sabchareon Chukiat Sirivichayakul Kriengsak Limkittikul Pornthep Chanthavanich Saravudh Suvannadabba Vithaya Jiwariyavej Wut Dulyachai Krisana Pengsaa Harold S Margolis G William Letson Dengue infection in children in Ratchaburi, Thailand: a cohort study. I. Epidemiology of symptomatic acute dengue infection in children, 2006-2009.
description	<h4>Background</h4>There is an urgent need to field test dengue vaccines to determine their role in the control of the disease. Our aims were to study dengue epidemiology and prepare the site for a dengue vaccine efficacy trial.<h4>Methods and findings</h4>We performed a prospective cohort study of children in primary schools in central Thailand from 2006 through 2009. We assessed the epidemiology of dengue by active fever surveillance for acute febrile illness as detected by school absenteeism and telephone contact of parents, and dengue diagnostic testing. Dengue accounted for 394 (6.74%) of the 5,842 febrile cases identified in 2882, 3104, 2717 and 2312 student person-years over the four years, respectively. Dengue incidence was 1.77% in 2006, 3.58% in 2007, 5.74% in 2008 and 3.29% in 2009. Mean dengue incidence over the 4 years was 3.6%. Dengue virus (DENV) types were determined in 333 (84.5%) of positive specimens; DENV serotype 1 (DENV-1) was the most common (43%), followed by DENV-2 (29%), DENV-3 (20%) and DENV-4 (8%). Disease severity ranged from dengue hemorrhagic fever (DHF) in 42 (10.5%) cases, dengue fever (DF) in 142 (35.5%) cases and undifferentiated fever (UF) in 210 (52.5%) cases. All four DENV serotypes were involved in all disease severity. A majority of cases had secondary DENV infection, 95% in DHF, 88.7% in DF and 81.9% in UF. Two DHF (0.5%) cases had primary DENV-3 infection.<h4>Conclusion</h4>The results illustrate the high incidence of dengue with all four DENV serotypes in primary school children, with approximately 50% of disease manifesting as mild clinical symptoms of UF, not meeting the 1997 WHO criteria for dengue. Severe disease (DHF) occurred in one tenth of cases. Data of this type are required for clinical trials to evaluate the efficacy of dengue vaccines in large scale clinical trials.
format	article
author	Arunee Sabchareon Chukiat Sirivichayakul Kriengsak Limkittikul Pornthep Chanthavanich Saravudh Suvannadabba Vithaya Jiwariyavej Wut Dulyachai Krisana Pengsaa Harold S Margolis G William Letson
author_facet	Arunee Sabchareon Chukiat Sirivichayakul Kriengsak Limkittikul Pornthep Chanthavanich Saravudh Suvannadabba Vithaya Jiwariyavej Wut Dulyachai Krisana Pengsaa Harold S Margolis G William Letson
author_sort	Arunee Sabchareon
title	Dengue infection in children in Ratchaburi, Thailand: a cohort study. I. Epidemiology of symptomatic acute dengue infection in children, 2006-2009.
title_short	Dengue infection in children in Ratchaburi, Thailand: a cohort study. I. Epidemiology of symptomatic acute dengue infection in children, 2006-2009.
title_full	Dengue infection in children in Ratchaburi, Thailand: a cohort study. I. Epidemiology of symptomatic acute dengue infection in children, 2006-2009.
title_fullStr	Dengue infection in children in Ratchaburi, Thailand: a cohort study. I. Epidemiology of symptomatic acute dengue infection in children, 2006-2009.
title_full_unstemmed	Dengue infection in children in Ratchaburi, Thailand: a cohort study. I. Epidemiology of symptomatic acute dengue infection in children, 2006-2009.
title_sort	dengue infection in children in ratchaburi, thailand: a cohort study. i. epidemiology of symptomatic acute dengue infection in children, 2006-2009.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/98cf6a615b1945b19fdfd6dd73762c07
work_keys_str_mv	AT aruneesabchareon dengueinfectioninchildreninratchaburithailandacohortstudyiepidemiologyofsymptomaticacutedengueinfectioninchildren20062009 AT chukiatsirivichayakul dengueinfectioninchildreninratchaburithailandacohortstudyiepidemiologyofsymptomaticacutedengueinfectioninchildren20062009 AT kriengsaklimkittikul dengueinfectioninchildreninratchaburithailandacohortstudyiepidemiologyofsymptomaticacutedengueinfectioninchildren20062009 AT pornthepchanthavanich dengueinfectioninchildreninratchaburithailandacohortstudyiepidemiologyofsymptomaticacutedengueinfectioninchildren20062009 AT saravudhsuvannadabba dengueinfectioninchildreninratchaburithailandacohortstudyiepidemiologyofsymptomaticacutedengueinfectioninchildren20062009 AT vithayajiwariyavej dengueinfectioninchildreninratchaburithailandacohortstudyiepidemiologyofsymptomaticacutedengueinfectioninchildren20062009 AT wutdulyachai dengueinfectioninchildreninratchaburithailandacohortstudyiepidemiologyofsymptomaticacutedengueinfectioninchildren20062009 AT krisanapengsaa dengueinfectioninchildreninratchaburithailandacohortstudyiepidemiologyofsymptomaticacutedengueinfectioninchildren20062009 AT haroldsmargolis dengueinfectioninchildreninratchaburithailandacohortstudyiepidemiologyofsymptomaticacutedengueinfectioninchildren20062009 AT gwilliamletson dengueinfectioninchildreninratchaburithailandacohortstudyiepidemiologyofsymptomaticacutedengueinfectioninchildren20062009
_version_	1718420979834683392

Dengue infection in children in Ratchaburi, Thailand: a cohort study. I. Epidemiology of symptomatic acute dengue infection in children, 2006-2009.

Ejemplares similares