The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

Abstract The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients ma...

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Autores principales:	Khalid El Bairi, Harry R. Haynes, Elizabeth Blackley, Susan Fineberg, Jeffrey Shear, Sophia Turner, Juliana Ribeiro de Freitas, Daniel Sur, Luis Claudio Amendola, Masoumeh Gharib, Amine Kallala, Indu Arun, Farid Azmoudeh-Ardalan, Luciana Fujimoto, Luz F. Sua, Shi-Wei Liu, Huang-Chun Lien, Pawan Kirtani, Marcelo Balancin, Hicham El Attar, Prerna Guleria, Wenxian Yang, Emad Shash, I-Chun Chen, Veronica Bautista, Jose Fernando Do Prado Moura, Bernardo L. Rapoport, Carlos Castaneda, Eunice Spengler, Gabriela Acosta-Haab, Isabel Frahm, Joselyn Sanchez, Miluska Castillo, Najat Bouchmaa, Reena R. Md Zin, Ruohong Shui, Timothy Onyuma, Wentao Yang, Zaheed Husain, Karen Willard-Gallo, An Coosemans, Edith A. Perez, Elena Provenzano, Paula Gonzalez Ericsson, Eduardo Richardet, Ravi Mehrotra, Sandra Sarancone, Anna Ehinger, David L. Rimm, John M. S. Bartlett, Giuseppe Viale, Carsten Denkert, Akira I. Hida, Christos Sotiriou, Sibylle Loibl, Stephen M. Hewitt, Sunil Badve, William Fraser Symmans, Rim S. Kim, Giancarlo Pruneri, Shom Goel, Prudence A. Francis, Gloria Inurrigarro, Rin Yamaguchi, Hernan Garcia-Rivello, Hugo Horlings, Said Afqir, Roberto Salgado, Sylvia Adams, Marleen Kok, Maria Vittoria Dieci, Stefan Michiels, Sandra Demaria, Sherene Loi, The International Immuno-Oncology Biomarker Working Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/98d18f7227c34bcb8909cccb39302c30
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spelling	oai:doaj.org-article:98d18f7227c34bcb8909cccb39302c302021-12-05T12:20:20ZThe tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group10.1038/s41523-021-00346-12374-4677https://doaj.org/article/98d18f7227c34bcb8909cccb39302c302021-12-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00346-1https://doaj.org/toc/2374-4677Abstract The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC.Khalid El BairiHarry R. HaynesElizabeth BlackleySusan FinebergJeffrey ShearSophia TurnerJuliana Ribeiro de FreitasDaniel SurLuis Claudio AmendolaMasoumeh GharibAmine KallalaIndu ArunFarid Azmoudeh-ArdalanLuciana FujimotoLuz F. SuaShi-Wei LiuHuang-Chun LienPawan KirtaniMarcelo BalancinHicham El AttarPrerna GuleriaWenxian YangEmad ShashI-Chun ChenVeronica BautistaJose Fernando Do Prado MouraBernardo L. RapoportCarlos CastanedaEunice SpenglerGabriela Acosta-HaabIsabel FrahmJoselyn SanchezMiluska CastilloNajat BouchmaaReena R. Md ZinRuohong ShuiTimothy OnyumaWentao YangZaheed HusainKaren Willard-GalloAn CoosemansEdith A. PerezElena ProvenzanoPaula Gonzalez EricssonEduardo RichardetRavi MehrotraSandra SaranconeAnna EhingerDavid L. RimmJohn M. S. BartlettGiuseppe VialeCarsten DenkertAkira I. HidaChristos SotiriouSibylle LoiblStephen M. HewittSunil BadveWilliam Fraser SymmansRim S. KimGiancarlo PruneriShom GoelPrudence A. FrancisGloria InurrigarroRin YamaguchiHernan Garcia-RivelloHugo HorlingsSaid AfqirRoberto SalgadoSylvia AdamsMarleen KokMaria Vittoria DieciStefan MichielsSandra DemariaSherene LoiThe International Immuno-Oncology Biomarker Working GroupNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Khalid El Bairi Harry R. Haynes Elizabeth Blackley Susan Fineberg Jeffrey Shear Sophia Turner Juliana Ribeiro de Freitas Daniel Sur Luis Claudio Amendola Masoumeh Gharib Amine Kallala Indu Arun Farid Azmoudeh-Ardalan Luciana Fujimoto Luz F. Sua Shi-Wei Liu Huang-Chun Lien Pawan Kirtani Marcelo Balancin Hicham El Attar Prerna Guleria Wenxian Yang Emad Shash I-Chun Chen Veronica Bautista Jose Fernando Do Prado Moura Bernardo L. Rapoport Carlos Castaneda Eunice Spengler Gabriela Acosta-Haab Isabel Frahm Joselyn Sanchez Miluska Castillo Najat Bouchmaa Reena R. Md Zin Ruohong Shui Timothy Onyuma Wentao Yang Zaheed Husain Karen Willard-Gallo An Coosemans Edith A. Perez Elena Provenzano Paula Gonzalez Ericsson Eduardo Richardet Ravi Mehrotra Sandra Sarancone Anna Ehinger David L. Rimm John M. S. Bartlett Giuseppe Viale Carsten Denkert Akira I. Hida Christos Sotiriou Sibylle Loibl Stephen M. Hewitt Sunil Badve William Fraser Symmans Rim S. Kim Giancarlo Pruneri Shom Goel Prudence A. Francis Gloria Inurrigarro Rin Yamaguchi Hernan Garcia-Rivello Hugo Horlings Said Afqir Roberto Salgado Sylvia Adams Marleen Kok Maria Vittoria Dieci Stefan Michiels Sandra Demaria Sherene Loi The International Immuno-Oncology Biomarker Working Group The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
description	Abstract The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC.
format	article
author	Khalid El Bairi Harry R. Haynes Elizabeth Blackley Susan Fineberg Jeffrey Shear Sophia Turner Juliana Ribeiro de Freitas Daniel Sur Luis Claudio Amendola Masoumeh Gharib Amine Kallala Indu Arun Farid Azmoudeh-Ardalan Luciana Fujimoto Luz F. Sua Shi-Wei Liu Huang-Chun Lien Pawan Kirtani Marcelo Balancin Hicham El Attar Prerna Guleria Wenxian Yang Emad Shash I-Chun Chen Veronica Bautista Jose Fernando Do Prado Moura Bernardo L. Rapoport Carlos Castaneda Eunice Spengler Gabriela Acosta-Haab Isabel Frahm Joselyn Sanchez Miluska Castillo Najat Bouchmaa Reena R. Md Zin Ruohong Shui Timothy Onyuma Wentao Yang Zaheed Husain Karen Willard-Gallo An Coosemans Edith A. Perez Elena Provenzano Paula Gonzalez Ericsson Eduardo Richardet Ravi Mehrotra Sandra Sarancone Anna Ehinger David L. Rimm John M. S. Bartlett Giuseppe Viale Carsten Denkert Akira I. Hida Christos Sotiriou Sibylle Loibl Stephen M. Hewitt Sunil Badve William Fraser Symmans Rim S. Kim Giancarlo Pruneri Shom Goel Prudence A. Francis Gloria Inurrigarro Rin Yamaguchi Hernan Garcia-Rivello Hugo Horlings Said Afqir Roberto Salgado Sylvia Adams Marleen Kok Maria Vittoria Dieci Stefan Michiels Sandra Demaria Sherene Loi The International Immuno-Oncology Biomarker Working Group
author_facet	Khalid El Bairi Harry R. Haynes Elizabeth Blackley Susan Fineberg Jeffrey Shear Sophia Turner Juliana Ribeiro de Freitas Daniel Sur Luis Claudio Amendola Masoumeh Gharib Amine Kallala Indu Arun Farid Azmoudeh-Ardalan Luciana Fujimoto Luz F. Sua Shi-Wei Liu Huang-Chun Lien Pawan Kirtani Marcelo Balancin Hicham El Attar Prerna Guleria Wenxian Yang Emad Shash I-Chun Chen Veronica Bautista Jose Fernando Do Prado Moura Bernardo L. Rapoport Carlos Castaneda Eunice Spengler Gabriela Acosta-Haab Isabel Frahm Joselyn Sanchez Miluska Castillo Najat Bouchmaa Reena R. Md Zin Ruohong Shui Timothy Onyuma Wentao Yang Zaheed Husain Karen Willard-Gallo An Coosemans Edith A. Perez Elena Provenzano Paula Gonzalez Ericsson Eduardo Richardet Ravi Mehrotra Sandra Sarancone Anna Ehinger David L. Rimm John M. S. Bartlett Giuseppe Viale Carsten Denkert Akira I. Hida Christos Sotiriou Sibylle Loibl Stephen M. Hewitt Sunil Badve William Fraser Symmans Rim S. Kim Giancarlo Pruneri Shom Goel Prudence A. Francis Gloria Inurrigarro Rin Yamaguchi Hernan Garcia-Rivello Hugo Horlings Said Afqir Roberto Salgado Sylvia Adams Marleen Kok Maria Vittoria Dieci Stefan Michiels Sandra Demaria Sherene Loi The International Immuno-Oncology Biomarker Working Group
author_sort	Khalid El Bairi
title	The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
title_short	The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
title_full	The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
title_fullStr	The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
title_full_unstemmed	The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
title_sort	tale of tils in breast cancer: a report from the international immuno-oncology biomarker working group
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/98d18f7227c34bcb8909cccb39302c30
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The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group

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