Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells
The authors show that graded molecular heterogeneity in metabotropic pathways underlies a continuum of temporal responses in cerebellar unipolar brush cells (UBCs). This allows the UBC population to serve as a cell-autonomous basis for temporal integration and learning over multiple time scales.
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Nature Portfolio
2021
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oai:doaj.org-article:98d53dab60cf463d91e36550272c31ee2021-12-02T19:16:33ZGraded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells10.1038/s41467-021-22893-82041-1723https://doaj.org/article/98d53dab60cf463d91e36550272c31ee2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22893-8https://doaj.org/toc/2041-1723The authors show that graded molecular heterogeneity in metabotropic pathways underlies a continuum of temporal responses in cerebellar unipolar brush cells (UBCs). This allows the UBC population to serve as a cell-autonomous basis for temporal integration and learning over multiple time scales.Chong GuoVincent HusonEvan Z. MacoskoWade G. RegehrNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Chong Guo Vincent Huson Evan Z. Macosko Wade G. Regehr Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells |
| description |
The authors show that graded molecular heterogeneity in metabotropic pathways underlies a continuum of temporal responses in cerebellar unipolar brush cells (UBCs). This allows the UBC population to serve as a cell-autonomous basis for temporal integration and learning over multiple time scales. |
| format |
article |
| author |
Chong Guo Vincent Huson Evan Z. Macosko Wade G. Regehr |
| author_facet |
Chong Guo Vincent Huson Evan Z. Macosko Wade G. Regehr |
| author_sort |
Chong Guo |
| title |
Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells |
| title_short |
Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells |
| title_full |
Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells |
| title_fullStr |
Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells |
| title_full_unstemmed |
Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells |
| title_sort |
graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/98d53dab60cf463d91e36550272c31ee |
| work_keys_str_mv |
AT chongguo gradedheterogeneityofmetabotropicsignalingunderliesacontinuumofcellintrinsictemporalresponsesinunipolarbrushcells AT vincenthuson gradedheterogeneityofmetabotropicsignalingunderliesacontinuumofcellintrinsictemporalresponsesinunipolarbrushcells AT evanzmacosko gradedheterogeneityofmetabotropicsignalingunderliesacontinuumofcellintrinsictemporalresponsesinunipolarbrushcells AT wadegregehr gradedheterogeneityofmetabotropicsignalingunderliesacontinuumofcellintrinsictemporalresponsesinunipolarbrushcells |
| _version_ |
1718376928318062592 |