Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

4E-BP1 is a translational repressor critical in mTOR signaling, whereas Snail is a critical promoter of epithelial to mesenchymal transition. Here the authors show that Snail induces resistance to mTOR inhibitors by repressing 4E-BP1 expression and promoting cell cycle progression via upregulating c...

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Autores principales:	Jun Wang, Qing Ye, Yanan Cao, Yubin Guo, Xiuping Huang, Wenting Mi, Side Liu, Chi Wang, Hsin-Sheng Yang, Binhua P. Zhou, B. Mark Evers, Qing-Bai She
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98d69d5d0fa346438618213828d6788a
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spelling	oai:doaj.org-article:98d69d5d0fa346438618213828d6788a2021-12-02T14:41:00ZSnail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP110.1038/s41467-017-02243-32041-1723https://doaj.org/article/98d69d5d0fa346438618213828d6788a2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02243-3https://doaj.org/toc/2041-17234E-BP1 is a translational repressor critical in mTOR signaling, whereas Snail is a critical promoter of epithelial to mesenchymal transition. Here the authors show that Snail induces resistance to mTOR inhibitors by repressing 4E-BP1 expression and promoting cell cycle progression via upregulating cycD.Jun WangQing YeYanan CaoYubin GuoXiuping HuangWenting MiSide LiuChi WangHsin-Sheng YangBinhua P. ZhouB. Mark EversQing-Bai SheNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun Wang Qing Ye Yanan Cao Yubin Guo Xiuping Huang Wenting Mi Side Liu Chi Wang Hsin-Sheng Yang Binhua P. Zhou B. Mark Evers Qing-Bai She Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1
description	4E-BP1 is a translational repressor critical in mTOR signaling, whereas Snail is a critical promoter of epithelial to mesenchymal transition. Here the authors show that Snail induces resistance to mTOR inhibitors by repressing 4E-BP1 expression and promoting cell cycle progression via upregulating cycD.
format	article
author	Jun Wang Qing Ye Yanan Cao Yubin Guo Xiuping Huang Wenting Mi Side Liu Chi Wang Hsin-Sheng Yang Binhua P. Zhou B. Mark Evers Qing-Bai She
author_facet	Jun Wang Qing Ye Yanan Cao Yubin Guo Xiuping Huang Wenting Mi Side Liu Chi Wang Hsin-Sheng Yang Binhua P. Zhou B. Mark Evers Qing-Bai She
author_sort	Jun Wang
title	Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1
title_short	Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1
title_full	Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1
title_fullStr	Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1
title_full_unstemmed	Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1
title_sort	snail determines the therapeutic response to mtor kinase inhibitors by transcriptional repression of 4e-bp1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/98d69d5d0fa346438618213828d6788a
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Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1

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