Protein-altering germline mutations implicate novel genes related to lung cancer development

In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk.

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Autores principales:	Xuemei Ji, Semanti Mukherjee, Maria Teresa Landi, Yohan Bosse, Philippe Joubert, Dakai Zhu, Ivan Gorlov, Xiangjun Xiao, Younghun Han, Olga Gorlova, Rayjean J. Hung, Yonathan Brhane, Robert Carreras-Torres, David C. Christiani, Neil Caporaso, Mattias Johansson, Geoffrey Liu, Stig E. Bojesen, Loic Le Marchand, Demetrios Albanes, Heike Bickeböller, Melinda C. Aldrich, William S. Bush, Adonina Tardon, Gad Rennert, Chu Chen, Jinyoung Byun, Konstantin H. Dragnev, John K. Field, Lambertus FA. Kiemeney, Philip Lazarus, Shan Zienolddiny, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Pier A. Bertazzi, Angela C. Pesatori, Nancy Diao, Li Su, Lei Song, Ruyang Zhang, Natasha Leighl, Jakob S. Johansen, Anders Mellemgaard, Walid Saliba, Christopher Haiman, Lynne Wilkens, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Erik H. F. M. van der Heijden, Jin Hee Kim, Michael P. A. Davies, Michael W. Marcus, Hans Brunnström, Jonas Manjer, Olle Melander, David C. Muller, Kim Overvad, Antonia Trichopoulou, Rosario Tumino, Gary E. Goodman, Angela Cox, Fiona Taylor, Penella Woll, Erich Wichmann, Thomas Muley, Angela Risch, Albert Rosenberger, Kjell Grankvist, Mikael Johansson, Frances Shepherd, Ming-Sound Tsao, Susanne M. Arnold, Eric B. Haura, Ciprian Bolca, Ivana Holcatova, Vladimir Janout, Milica Kontic, Jolanta Lissowska, Anush Mukeria, Simona Ognjanovic, Tadeusz M. Orlowski, Ghislaine Scelo, Beata Swiatkowska, David Zaridze, Per Bakke, Vidar Skaug, Lesley M. Butler, Kenneth Offit, Preethi Srinivasan, Chaitanya Bandlamudi, Matthew D. Hellmann, David B. Solit, Mark E. Robson, Charles M. Rudin, Zsofia K. Stadler, Barry S. Taylor, Michael F. Berger, Richard Houlston, John McLaughlin, Victoria Stevens, David C. Nickle, Ma’en Obeidat, Wim Timens, María Soler Artigas, Sanjay Shete, Hermann Brenner, Stephen Chanock, Paul Brennan, James D. McKay, Christopher I. Amos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98db56edb20d4123b824401859c438ab
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spelling	oai:doaj.org-article:98db56edb20d4123b824401859c438ab2021-12-02T14:35:46ZProtein-altering germline mutations implicate novel genes related to lung cancer development10.1038/s41467-020-15905-62041-1723https://doaj.org/article/98db56edb20d4123b824401859c438ab2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15905-6https://doaj.org/toc/2041-1723In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk.Xuemei JiSemanti MukherjeeMaria Teresa LandiYohan BossePhilippe JoubertDakai ZhuIvan GorlovXiangjun XiaoYounghun HanOlga GorlovaRayjean J. HungYonathan BrhaneRobert Carreras-TorresDavid C. ChristianiNeil CaporasoMattias JohanssonGeoffrey LiuStig E. BojesenLoic Le MarchandDemetrios AlbanesHeike BickeböllerMelinda C. AldrichWilliam S. BushAdonina TardonGad RennertChu ChenJinyoung ByunKonstantin H. DragnevJohn K. FieldLambertus FA. KiemeneyPhilip LazarusShan ZienolddinyStephen LamMatthew B. SchabathAngeline S. AndrewPier A. BertazziAngela C. PesatoriNancy DiaoLi SuLei SongRuyang ZhangNatasha LeighlJakob S. JohansenAnders MellemgaardWalid SalibaChristopher HaimanLynne WilkensAna Fernandez-SomoanoGuillermo Fernandez-TardonErik H. F. M. van der HeijdenJin Hee KimMichael P. A. DaviesMichael W. MarcusHans BrunnströmJonas ManjerOlle MelanderDavid C. MullerKim OvervadAntonia TrichopoulouRosario TuminoGary E. GoodmanAngela CoxFiona TaylorPenella WollErich WichmannThomas MuleyAngela RischAlbert RosenbergerKjell GrankvistMikael JohanssonFrances ShepherdMing-Sound TsaoSusanne M. ArnoldEric B. HauraCiprian BolcaIvana HolcatovaVladimir JanoutMilica KonticJolanta LissowskaAnush MukeriaSimona OgnjanovicTadeusz M. OrlowskiGhislaine SceloBeata SwiatkowskaDavid ZaridzePer BakkeVidar SkaugLesley M. ButlerKenneth OffitPreethi SrinivasanChaitanya BandlamudiMatthew D. HellmannDavid B. SolitMark E. RobsonCharles M. RudinZsofia K. StadlerBarry S. TaylorMichael F. BergerRichard HoulstonJohn McLaughlinVictoria StevensDavid C. NickleMa’en ObeidatWim TimensMaría Soler ArtigasSanjay SheteHermann BrennerStephen ChanockPaul BrennanJames D. McKayChristopher I. AmosNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuemei Ji Semanti Mukherjee Maria Teresa Landi Yohan Bosse Philippe Joubert Dakai Zhu Ivan Gorlov Xiangjun Xiao Younghun Han Olga Gorlova Rayjean J. Hung Yonathan Brhane Robert Carreras-Torres David C. Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E. Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C. Aldrich William S. Bush Adonina Tardon Gad Rennert Chu Chen Jinyoung Byun Konstantin H. Dragnev John K. Field Lambertus FA. Kiemeney Philip Lazarus Shan Zienolddiny Stephen Lam Matthew B. Schabath Angeline S. Andrew Pier A. Bertazzi Angela C. Pesatori Nancy Diao Li Su Lei Song Ruyang Zhang Natasha Leighl Jakob S. Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H. F. M. van der Heijden Jin Hee Kim Michael P. A. Davies Michael W. Marcus Hans Brunnström Jonas Manjer Olle Melander David C. Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Gary E. Goodman Angela Cox Fiona Taylor Penella Woll Erich Wichmann Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M. Arnold Eric B. Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M. Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Lesley M. Butler Kenneth Offit Preethi Srinivasan Chaitanya Bandlamudi Matthew D. Hellmann David B. Solit Mark E. Robson Charles M. Rudin Zsofia K. Stadler Barry S. Taylor Michael F. Berger Richard Houlston John McLaughlin Victoria Stevens David C. Nickle Ma’en Obeidat Wim Timens María Soler Artigas Sanjay Shete Hermann Brenner Stephen Chanock Paul Brennan James D. McKay Christopher I. Amos Protein-altering germline mutations implicate novel genes related to lung cancer development
description	In lung cancer, relatively few germline mutations are known to impact risk. Here the authors looked at rare variants in 39,146 individuals and find novel germline mutations associated with risk, as well as implicating ATM and a new candidate gene for lung cancer risk.
format	article
author	Xuemei Ji Semanti Mukherjee Maria Teresa Landi Yohan Bosse Philippe Joubert Dakai Zhu Ivan Gorlov Xiangjun Xiao Younghun Han Olga Gorlova Rayjean J. Hung Yonathan Brhane Robert Carreras-Torres David C. Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E. Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C. Aldrich William S. Bush Adonina Tardon Gad Rennert Chu Chen Jinyoung Byun Konstantin H. Dragnev John K. Field Lambertus FA. Kiemeney Philip Lazarus Shan Zienolddiny Stephen Lam Matthew B. Schabath Angeline S. Andrew Pier A. Bertazzi Angela C. Pesatori Nancy Diao Li Su Lei Song Ruyang Zhang Natasha Leighl Jakob S. Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H. F. M. van der Heijden Jin Hee Kim Michael P. A. Davies Michael W. Marcus Hans Brunnström Jonas Manjer Olle Melander David C. Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Gary E. Goodman Angela Cox Fiona Taylor Penella Woll Erich Wichmann Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M. Arnold Eric B. Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M. Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Lesley M. Butler Kenneth Offit Preethi Srinivasan Chaitanya Bandlamudi Matthew D. Hellmann David B. Solit Mark E. Robson Charles M. Rudin Zsofia K. Stadler Barry S. Taylor Michael F. Berger Richard Houlston John McLaughlin Victoria Stevens David C. Nickle Ma’en Obeidat Wim Timens María Soler Artigas Sanjay Shete Hermann Brenner Stephen Chanock Paul Brennan James D. McKay Christopher I. Amos
author_facet	Xuemei Ji Semanti Mukherjee Maria Teresa Landi Yohan Bosse Philippe Joubert Dakai Zhu Ivan Gorlov Xiangjun Xiao Younghun Han Olga Gorlova Rayjean J. Hung Yonathan Brhane Robert Carreras-Torres David C. Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E. Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C. Aldrich William S. Bush Adonina Tardon Gad Rennert Chu Chen Jinyoung Byun Konstantin H. Dragnev John K. Field Lambertus FA. Kiemeney Philip Lazarus Shan Zienolddiny Stephen Lam Matthew B. Schabath Angeline S. Andrew Pier A. Bertazzi Angela C. Pesatori Nancy Diao Li Su Lei Song Ruyang Zhang Natasha Leighl Jakob S. Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H. F. M. van der Heijden Jin Hee Kim Michael P. A. Davies Michael W. Marcus Hans Brunnström Jonas Manjer Olle Melander David C. Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Gary E. Goodman Angela Cox Fiona Taylor Penella Woll Erich Wichmann Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M. Arnold Eric B. Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M. Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Lesley M. Butler Kenneth Offit Preethi Srinivasan Chaitanya Bandlamudi Matthew D. Hellmann David B. Solit Mark E. Robson Charles M. Rudin Zsofia K. Stadler Barry S. Taylor Michael F. Berger Richard Houlston John McLaughlin Victoria Stevens David C. Nickle Ma’en Obeidat Wim Timens María Soler Artigas Sanjay Shete Hermann Brenner Stephen Chanock Paul Brennan James D. McKay Christopher I. Amos
author_sort	Xuemei Ji
title	Protein-altering germline mutations implicate novel genes related to lung cancer development
title_short	Protein-altering germline mutations implicate novel genes related to lung cancer development
title_full	Protein-altering germline mutations implicate novel genes related to lung cancer development
title_fullStr	Protein-altering germline mutations implicate novel genes related to lung cancer development
title_full_unstemmed	Protein-altering germline mutations implicate novel genes related to lung cancer development
title_sort	protein-altering germline mutations implicate novel genes related to lung cancer development
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/98db56edb20d4123b824401859c438ab
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Protein-altering germline mutations implicate novel genes related to lung cancer development

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