Calcium pyrophosphate crystal deposition disease: diagnosis and treatment

José Luis Rosales-Alexander,1 Jerónimo Balsalobre Aznar,1 César Magro-Checa2 1Rheumatology Department, Hospiten Ramblas, Santa Cruz de Tenerife, 2Rheumatology Department, San Cecilio University Hospital, Granada, Spain Abstract: Calcium pyrophosphate dihydrate crys...

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Autores principales:	Rosales-Alexander JL, Balsalobre Aznar J, Magro-Checa C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/98dc04b5e3894e8aa9f25ced14ab1154
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spelling	oai:doaj.org-article:98dc04b5e3894e8aa9f25ced14ab11542021-12-02T03:47:29ZCalcium pyrophosphate crystal deposition disease: diagnosis and treatment1179-156Xhttps://doaj.org/article/98dc04b5e3894e8aa9f25ced14ab11542014-05-01T00:00:00Zhttp://www.dovepress.com/calcium-pyrophosphate-crystal-deposition-disease-diagnosis-and-treatme-a16758https://doaj.org/toc/1179-156X José Luis Rosales-Alexander,1 Jerónimo Balsalobre Aznar,1 César Magro-Checa2 1Rheumatology Department, Hospiten Ramblas, Santa Cruz de Tenerife, 2Rheumatology Department, San Cecilio University Hospital, Granada, Spain Abstract: Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) is an inflammatory arthritis produced by the deposition of calcium pyrophosphate (CPP) crystals in the synovium and periarticular soft tissues. It is the third most common inflammatory arthritis. Diagnosis is suspected on the basis of the clinical picture and radiographic/laboratory findings. The reference standard for the diagnosis of CPPD is based on the identification of CPP crystals in synovial fluid by light microscopy, compensated polarized light microscopy, or phase contrast microscopy. Most treatment approaches for CPPD are based upon clinical experience and not upon controlled trials. They range – depending on the subtype and the characteristics of symptoms – from no treatment to interleukin-1 blockade antibodies or specific therapy for an underlying disease. This review summarizes all we know so far about the diagnosis and management of CPPD. Keywords: calcium pyrophosphate dihydrate deposition disease, CPPD, chondrocalcinosis, crystal-induced arthritidesRosales-Alexander JLBalsalobre Aznar JMagro-Checa CDove Medical PressarticleDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol 2014, Iss default, Pp 39-47 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935
spellingShingle	Diseases of the musculoskeletal system RC925-935 Rosales-Alexander JL Balsalobre Aznar J Magro-Checa C Calcium pyrophosphate crystal deposition disease: diagnosis and treatment
description	José Luis Rosales-Alexander,1 Jerónimo Balsalobre Aznar,1 César Magro-Checa2 1Rheumatology Department, Hospiten Ramblas, Santa Cruz de Tenerife, 2Rheumatology Department, San Cecilio University Hospital, Granada, Spain Abstract: Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) is an inflammatory arthritis produced by the deposition of calcium pyrophosphate (CPP) crystals in the synovium and periarticular soft tissues. It is the third most common inflammatory arthritis. Diagnosis is suspected on the basis of the clinical picture and radiographic/laboratory findings. The reference standard for the diagnosis of CPPD is based on the identification of CPP crystals in synovial fluid by light microscopy, compensated polarized light microscopy, or phase contrast microscopy. Most treatment approaches for CPPD are based upon clinical experience and not upon controlled trials. They range – depending on the subtype and the characteristics of symptoms – from no treatment to interleukin-1 blockade antibodies or specific therapy for an underlying disease. This review summarizes all we know so far about the diagnosis and management of CPPD. Keywords: calcium pyrophosphate dihydrate deposition disease, CPPD, chondrocalcinosis, crystal-induced arthritides
format	article
author	Rosales-Alexander JL Balsalobre Aznar J Magro-Checa C
author_facet	Rosales-Alexander JL Balsalobre Aznar J Magro-Checa C
author_sort	Rosales-Alexander JL
title	Calcium pyrophosphate crystal deposition disease: diagnosis and treatment
title_short	Calcium pyrophosphate crystal deposition disease: diagnosis and treatment
title_full	Calcium pyrophosphate crystal deposition disease: diagnosis and treatment
title_fullStr	Calcium pyrophosphate crystal deposition disease: diagnosis and treatment
title_full_unstemmed	Calcium pyrophosphate crystal deposition disease: diagnosis and treatment
title_sort	calcium pyrophosphate crystal deposition disease: diagnosis and treatment
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/98dc04b5e3894e8aa9f25ced14ab1154
work_keys_str_mv	AT rosalesalexanderjl calciumpyrophosphatecrystaldepositiondiseasediagnosisandtreatment AT balsalobreaznarj calciumpyrophosphatecrystaldepositiondiseasediagnosisandtreatment AT magrochecac calciumpyrophosphatecrystaldepositiondiseasediagnosisandtreatment
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Calcium pyrophosphate crystal deposition disease: diagnosis and treatment

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