Corticosterone-Mediated Physiological Stress Alters Liver, Kidney, and Breast Muscle Metabolomic Profiles in Chickens

The impact of physiological stress on the metabolomes of liver, kidney, and breast muscle was investigated in chickens. To incite a stress response, birds were continuously administered corticosterone (CORT) in their drinking water at three doses (0, 10, and 30 mg L<sup>−1</sup>), and th...

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Autores principales:	Catherine L. J. Brown, Sarah J. M. Zaytsoff, Tony Montina, G. Douglas Inglis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chickens physiological stress corticosterone feathers <sup>1</sup>H-NMR metabolomics Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/98df64bbd3bd4e848d35388fa25c17ba
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spelling	oai:doaj.org-article:98df64bbd3bd4e848d35388fa25c17ba2021-11-25T16:14:15ZCorticosterone-Mediated Physiological Stress Alters Liver, Kidney, and Breast Muscle Metabolomic Profiles in Chickens10.3390/ani111130562076-2615https://doaj.org/article/98df64bbd3bd4e848d35388fa25c17ba2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3056https://doaj.org/toc/2076-2615The impact of physiological stress on the metabolomes of liver, kidney, and breast muscle was investigated in chickens. To incite a stress response, birds were continuously administered corticosterone (CORT) in their drinking water at three doses (0, 10, and 30 mg L<sup>−1</sup>), and they were sampled 1, 5, and 12 days after the start of the CORT administration. To solubilize CORT, it was first dissolved in ethanol and then added to water. The administration of ethanol alone significantly altered branched chain amino acid metabolism in both the liver and the kidney, and amino acid and nitrogen metabolism in breast muscle. CORT significantly altered sugar and amino acid metabolism in all three tissues, but to a much greater degree than ethanol alone. In this regard, CORT administration significantly altered 11, 46, and 14 unique metabolites in liver, kidney, and breast muscle, respectively. Many of the metabolites that were affected by CORT administration, such as mannose and glucose, were previously linked to increases in glycosylation and gluconeogenesis in chickens under conditions of production stress. Moreover, several of these metabolites, such as dimethylglycine, galactose, and carnosine were also previously linked to reduced quality meat. In summary, the administration of CORT in chickens significantly modulated host metabolism. Moreover, results indicated that energy potentials are diverted from muscle anabolism to muscle catabolism and gluconeogenesis during periods of stress.Catherine L. J. BrownSarah J. M. ZaytsoffTony MontinaG. Douglas InglisMDPI AGarticlechickensphysiological stresscorticosteronefeathers<sup>1</sup>H-NMRmetabolomicsVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3056, p 3056 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chickens physiological stress corticosterone feathers <sup>1</sup>H-NMR metabolomics Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	chickens physiological stress corticosterone feathers <sup>1</sup>H-NMR metabolomics Veterinary medicine SF600-1100 Zoology QL1-991 Catherine L. J. Brown Sarah J. M. Zaytsoff Tony Montina G. Douglas Inglis Corticosterone-Mediated Physiological Stress Alters Liver, Kidney, and Breast Muscle Metabolomic Profiles in Chickens
description	The impact of physiological stress on the metabolomes of liver, kidney, and breast muscle was investigated in chickens. To incite a stress response, birds were continuously administered corticosterone (CORT) in their drinking water at three doses (0, 10, and 30 mg L<sup>−1</sup>), and they were sampled 1, 5, and 12 days after the start of the CORT administration. To solubilize CORT, it was first dissolved in ethanol and then added to water. The administration of ethanol alone significantly altered branched chain amino acid metabolism in both the liver and the kidney, and amino acid and nitrogen metabolism in breast muscle. CORT significantly altered sugar and amino acid metabolism in all three tissues, but to a much greater degree than ethanol alone. In this regard, CORT administration significantly altered 11, 46, and 14 unique metabolites in liver, kidney, and breast muscle, respectively. Many of the metabolites that were affected by CORT administration, such as mannose and glucose, were previously linked to increases in glycosylation and gluconeogenesis in chickens under conditions of production stress. Moreover, several of these metabolites, such as dimethylglycine, galactose, and carnosine were also previously linked to reduced quality meat. In summary, the administration of CORT in chickens significantly modulated host metabolism. Moreover, results indicated that energy potentials are diverted from muscle anabolism to muscle catabolism and gluconeogenesis during periods of stress.
format	article
author	Catherine L. J. Brown Sarah J. M. Zaytsoff Tony Montina G. Douglas Inglis
author_facet	Catherine L. J. Brown Sarah J. M. Zaytsoff Tony Montina G. Douglas Inglis
author_sort	Catherine L. J. Brown
title	Corticosterone-Mediated Physiological Stress Alters Liver, Kidney, and Breast Muscle Metabolomic Profiles in Chickens
title_short	Corticosterone-Mediated Physiological Stress Alters Liver, Kidney, and Breast Muscle Metabolomic Profiles in Chickens
title_full	Corticosterone-Mediated Physiological Stress Alters Liver, Kidney, and Breast Muscle Metabolomic Profiles in Chickens
title_fullStr	Corticosterone-Mediated Physiological Stress Alters Liver, Kidney, and Breast Muscle Metabolomic Profiles in Chickens
title_full_unstemmed	Corticosterone-Mediated Physiological Stress Alters Liver, Kidney, and Breast Muscle Metabolomic Profiles in Chickens
title_sort	corticosterone-mediated physiological stress alters liver, kidney, and breast muscle metabolomic profiles in chickens
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/98df64bbd3bd4e848d35388fa25c17ba
work_keys_str_mv	AT catherineljbrown corticosteronemediatedphysiologicalstressaltersliverkidneyandbreastmusclemetabolomicprofilesinchickens AT sarahjmzaytsoff corticosteronemediatedphysiologicalstressaltersliverkidneyandbreastmusclemetabolomicprofilesinchickens AT tonymontina corticosteronemediatedphysiologicalstressaltersliverkidneyandbreastmusclemetabolomicprofilesinchickens AT gdouglasinglis corticosteronemediatedphysiologicalstressaltersliverkidneyandbreastmusclemetabolomicprofilesinchickens
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Corticosterone-Mediated Physiological Stress Alters Liver, Kidney, and Breast Muscle Metabolomic Profiles in Chickens

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