Prognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression

Abstract Psychiatric disorders such as anxiety and depression precipitated by substance use occurred during both use and withdrawal. Exosomes play significant roles in biological functions and regulate numerous physiological and pathological processes in various diseases, in particular substance use...

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Autores principales:	Fengrong Chen, Lei Zou, Yicong Dai, Jiaxue Sun, Cheng Chen, Yongjin Zhang, Qingyan Peng, Zunyue Zhang, Zhenrong Xie, Hongjin Wu, Weiwei Tian, Xu Yu, Juehua Yu, Kunhua Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/98dfe94b8217482a84b4cc0c5780fdac
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spelling	oai:doaj.org-article:98dfe94b8217482a84b4cc0c5780fdac2021-12-02T13:17:55ZPrognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression10.1038/s41598-021-84501-52045-2322https://doaj.org/article/98dfe94b8217482a84b4cc0c5780fdac2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84501-5https://doaj.org/toc/2045-2322Abstract Psychiatric disorders such as anxiety and depression precipitated by substance use occurred during both use and withdrawal. Exosomes play significant roles in biological functions and regulate numerous physiological and pathological processes in various diseases, in particular substance use disorders (SUDs) and other psychiatric disorders. To better understand the role of exosomal miRNAs in the pathology of symptoms of anxiety and depression in patients with SUDs, we first isolated circulating exosomes from heroin-dependent patients (HDPs) and methamphetamine-dependent patients (MDPs) and identified exosomal miRNAs that were differentially expressed between patients and healthy controls (HCs). Furthermore, the correlations between exosomal DE-miRNAs and symptoms of anxiety and depression which were measured using Hamilton-Anxiety (HAM-A)/Hamilton-Depression (HAM-D) Rating Scales in the participants. Notably, the expression level of exosomal hsa-miR-16-5p, hsa-miR-129-5p, hsa-miR-363-3p, and hsa-miR-92a-3p showed significantly negative correlations with HAM-A scores in both HDPs and MDPs. But all of the 4 DE-miRNAs lost significant correlations with HAM-D scores in HDPs. Functional annotation analyses showed that the target genes of the DE-miRNAs were mainly enriched for “synapse”, “cell adhesion”, “focal adhesion” and “MHC class II protein complex”. Our study suggests that a set of circulating exosomal miRNAs were associated with anxiety and depression in SUD patients and may have clinical utility as diagnostic and prognostic biomarkers.Fengrong ChenLei ZouYicong DaiJiaxue SunCheng ChenYongjin ZhangQingyan PengZunyue ZhangZhenrong XieHongjin WuWeiwei TianXu YuJuehua YuKunhua WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fengrong Chen Lei Zou Yicong Dai Jiaxue Sun Cheng Chen Yongjin Zhang Qingyan Peng Zunyue Zhang Zhenrong Xie Hongjin Wu Weiwei Tian Xu Yu Juehua Yu Kunhua Wang Prognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression
description	Abstract Psychiatric disorders such as anxiety and depression precipitated by substance use occurred during both use and withdrawal. Exosomes play significant roles in biological functions and regulate numerous physiological and pathological processes in various diseases, in particular substance use disorders (SUDs) and other psychiatric disorders. To better understand the role of exosomal miRNAs in the pathology of symptoms of anxiety and depression in patients with SUDs, we first isolated circulating exosomes from heroin-dependent patients (HDPs) and methamphetamine-dependent patients (MDPs) and identified exosomal miRNAs that were differentially expressed between patients and healthy controls (HCs). Furthermore, the correlations between exosomal DE-miRNAs and symptoms of anxiety and depression which were measured using Hamilton-Anxiety (HAM-A)/Hamilton-Depression (HAM-D) Rating Scales in the participants. Notably, the expression level of exosomal hsa-miR-16-5p, hsa-miR-129-5p, hsa-miR-363-3p, and hsa-miR-92a-3p showed significantly negative correlations with HAM-A scores in both HDPs and MDPs. But all of the 4 DE-miRNAs lost significant correlations with HAM-D scores in HDPs. Functional annotation analyses showed that the target genes of the DE-miRNAs were mainly enriched for “synapse”, “cell adhesion”, “focal adhesion” and “MHC class II protein complex”. Our study suggests that a set of circulating exosomal miRNAs were associated with anxiety and depression in SUD patients and may have clinical utility as diagnostic and prognostic biomarkers.
format	article
author	Fengrong Chen Lei Zou Yicong Dai Jiaxue Sun Cheng Chen Yongjin Zhang Qingyan Peng Zunyue Zhang Zhenrong Xie Hongjin Wu Weiwei Tian Xu Yu Juehua Yu Kunhua Wang
author_facet	Fengrong Chen Lei Zou Yicong Dai Jiaxue Sun Cheng Chen Yongjin Zhang Qingyan Peng Zunyue Zhang Zhenrong Xie Hongjin Wu Weiwei Tian Xu Yu Juehua Yu Kunhua Wang
author_sort	Fengrong Chen
title	Prognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression
title_short	Prognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression
title_full	Prognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression
title_fullStr	Prognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression
title_full_unstemmed	Prognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression
title_sort	prognostic plasma exosomal microrna biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/98dfe94b8217482a84b4cc0c5780fdac
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Prognostic plasma exosomal microRNA biomarkers in patients with substance use disorders presenting comorbid with anxiety and depression

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