Characteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics

Abstract The purpose of this study was to investigate the dynamic changes of histopathology, biomechanical properties, echo intensity, and ultrasound features in a collagenase-induced tendinopathy model of rat Achilles tendons, and to examine the associations among biomechanical properties, echo int...

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Autores principales:	Su-Ya Lee, Hsiao-Feng Chieh, Chien-Ju Lin, I-Ming Jou, Yung-Nien Sun, Li-Chieh Kuo, Po-Ting Wu, Fong-Chin Su
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/98e3a3d614ee4c4ba036f3f42bc3b3ce
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spelling	oai:doaj.org-article:98e3a3d614ee4c4ba036f3f42bc3b3ce2021-12-02T15:05:37ZCharacteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics10.1038/s41598-017-05466-y2045-2322https://doaj.org/article/98e3a3d614ee4c4ba036f3f42bc3b3ce2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05466-yhttps://doaj.org/toc/2045-2322Abstract The purpose of this study was to investigate the dynamic changes of histopathology, biomechanical properties, echo intensity, and ultrasound features in a collagenase-induced tendinopathy model of rat Achilles tendons, and to examine the associations among biomechanical properties, echo intensity, and ultrasound features. Forty-two rats received an ultrasound-guided collagenase injection on their left Achilles tendons, and needle puncture on the right ones as the control. At four, eight, and twelve weeks post-injury, the tendons were examined via measurements of their biomechanical properties, histopathological and ultrasonographic characteristics. The injured tendons showed significantly higher histopathological scores, lower Young’s modulus, and higher ultrasound feature scores than the those of control ones throughout the study period. Up to week 12, all injured tendons showed defective healing. The neovascularization score had a significant negative linear association with the failure stress and Young’s modulus. Maximum normalized echo intensity had a significant positive linear association with maximum strain. Therefore, neovascularization and maximum normalized echo intensity are associated with mechanically altered tendinopathic tendons. Non-invasive ultrasound methodology, including echo intensity and ultrasound feature scores, may provide useful information about biomechanical properties of tendinopathic tendons.Su-Ya LeeHsiao-Feng ChiehChien-Ju LinI-Ming JouYung-Nien SunLi-Chieh KuoPo-Ting WuFong-Chin SuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Su-Ya Lee Hsiao-Feng Chieh Chien-Ju Lin I-Ming Jou Yung-Nien Sun Li-Chieh Kuo Po-Ting Wu Fong-Chin Su Characteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics
description	Abstract The purpose of this study was to investigate the dynamic changes of histopathology, biomechanical properties, echo intensity, and ultrasound features in a collagenase-induced tendinopathy model of rat Achilles tendons, and to examine the associations among biomechanical properties, echo intensity, and ultrasound features. Forty-two rats received an ultrasound-guided collagenase injection on their left Achilles tendons, and needle puncture on the right ones as the control. At four, eight, and twelve weeks post-injury, the tendons were examined via measurements of their biomechanical properties, histopathological and ultrasonographic characteristics. The injured tendons showed significantly higher histopathological scores, lower Young’s modulus, and higher ultrasound feature scores than the those of control ones throughout the study period. Up to week 12, all injured tendons showed defective healing. The neovascularization score had a significant negative linear association with the failure stress and Young’s modulus. Maximum normalized echo intensity had a significant positive linear association with maximum strain. Therefore, neovascularization and maximum normalized echo intensity are associated with mechanically altered tendinopathic tendons. Non-invasive ultrasound methodology, including echo intensity and ultrasound feature scores, may provide useful information about biomechanical properties of tendinopathic tendons.
format	article
author	Su-Ya Lee Hsiao-Feng Chieh Chien-Ju Lin I-Ming Jou Yung-Nien Sun Li-Chieh Kuo Po-Ting Wu Fong-Chin Su
author_facet	Su-Ya Lee Hsiao-Feng Chieh Chien-Ju Lin I-Ming Jou Yung-Nien Sun Li-Chieh Kuo Po-Ting Wu Fong-Chin Su
author_sort	Su-Ya Lee
title	Characteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics
title_short	Characteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics
title_full	Characteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics
title_fullStr	Characteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics
title_full_unstemmed	Characteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics
title_sort	characteristics of sonography in a rat achilles tendinopathy model: possible non-invasive predictors of biomechanics
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/98e3a3d614ee4c4ba036f3f42bc3b3ce
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_version_	1718388783191162880

Characteristics of Sonography in a Rat Achilles Tendinopathy Model: Possible Non-invasive Predictors of Biomechanics

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