Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge whe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bharti Gupta, Varsha Mishra, Sankalp Gharat, Munira Momin, Abdelwahab Omri
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ocular drug delivery system hydroxypropyl methylcellulose carboxymethyl cellulose ethylcellulose methylcellulose hydroxyethyl cellulose Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/98e60f4a32404704a1139f759fb73c70
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:98e60f4a32404704a1139f759fb73c70
record_format	dspace
spelling	oai:doaj.org-article:98e60f4a32404704a1139f759fb73c702021-11-25T18:40:11ZCellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems10.3390/ph141112011424-8247https://doaj.org/article/98e60f4a32404704a1139f759fb73c702021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1201https://doaj.org/toc/1424-8247One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems.Bharti GuptaVarsha MishraSankalp GharatMunira MominAbdelwahab OmriMDPI AGarticleocular drug delivery systemhydroxypropyl methylcellulosecarboxymethyl celluloseethylcellulosemethylcellulosehydroxyethyl celluloseMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1201, p 1201 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ocular drug delivery system hydroxypropyl methylcellulose carboxymethyl cellulose ethylcellulose methylcellulose hydroxyethyl cellulose Medicine R Pharmacy and materia medica RS1-441
spellingShingle	ocular drug delivery system hydroxypropyl methylcellulose carboxymethyl cellulose ethylcellulose methylcellulose hydroxyethyl cellulose Medicine R Pharmacy and materia medica RS1-441 Bharti Gupta Varsha Mishra Sankalp Gharat Munira Momin Abdelwahab Omri Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
description	One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems.
format	article
author	Bharti Gupta Varsha Mishra Sankalp Gharat Munira Momin Abdelwahab Omri
author_facet	Bharti Gupta Varsha Mishra Sankalp Gharat Munira Momin Abdelwahab Omri
author_sort	Bharti Gupta
title	Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
title_short	Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
title_full	Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
title_fullStr	Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
title_full_unstemmed	Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems
title_sort	cellulosic polymers for enhancing drug bioavailability in ocular drug delivery systems
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/98e60f4a32404704a1139f759fb73c70
work_keys_str_mv	AT bhartigupta cellulosicpolymersforenhancingdrugbioavailabilityinoculardrugdeliverysystems AT varshamishra cellulosicpolymersforenhancingdrugbioavailabilityinoculardrugdeliverysystems AT sankalpgharat cellulosicpolymersforenhancingdrugbioavailabilityinoculardrugdeliverysystems AT muniramomin cellulosicpolymersforenhancingdrugbioavailabilityinoculardrugdeliverysystems AT abdelwahabomri cellulosicpolymersforenhancingdrugbioavailabilityinoculardrugdeliverysystems
_version_	1718410851491250176

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

Ejemplares similares