Impact of Systemic Volume Status on Cardiac Magnetic Resonance T1 Mapping

Abstract Diffuse myocardial fibrosis is a key pathophysiologic feature in heart failure and can be quantified by cardiac magnetic resonance (CMR) T1 mapping. However, increases in myocardial free water also prolong native T1 times and may impact fibrosis quantification. Thus far, the impact of syste...

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Autores principales:	Marlies Antlanger, Stefan Aschauer, Andreas A. Kammerlander, Franz Duca, Marcus D. Säemann, Diana Bonderman, Julia Mascherbauer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/98e6796a5ec3461490d9419119e4af95
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spelling	oai:doaj.org-article:98e6796a5ec3461490d9419119e4af952021-12-02T15:07:57ZImpact of Systemic Volume Status on Cardiac Magnetic Resonance T1 Mapping10.1038/s41598-018-23868-42045-2322https://doaj.org/article/98e6796a5ec3461490d9419119e4af952018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-23868-4https://doaj.org/toc/2045-2322Abstract Diffuse myocardial fibrosis is a key pathophysiologic feature in heart failure and can be quantified by cardiac magnetic resonance (CMR) T1 mapping. However, increases in myocardial free water also prolong native T1 times and may impact fibrosis quantification. Thus far, the impact of systemic patient volume status remains unclear. In this study, native T1 time by CMR was investigated in hemodialysis (HD) patients (n = 37) and compared with healthy controls (n = 35). Volume status was quantified by bioimpedance spectroscopy and correlated with CMR T1 time. While no differences between HD patients and controls were present with regard to age (p = 0.180), height (p = 0.535), weight (p = 0.559) and left ventricular (LV) ejection fraction (p = 0.273), cardiac size was significantly larger in HD patients (LV end-diastolic volume 164 ± 53 vs. 132 ± 26 ml, p = 0.002). Fluid overloaded HD patients had significantly longer native T1 times than normovolemic HD patients and healthy controls (1,042 ± 46 vs. 1,005 ± 49 vs. 998 ± 47 ms, p = 0.030). By regression analysis, T1 time was significantly associated with fluid status (r = 0.530, p = 0.009, post-HD fluid status). Our data strongly indicate that native CMR T1 time is significantly influenced by systemic volume status. As fluid overload is common in patients with cardiovascular diseases, this finding is important and requires further study.Marlies AntlangerStefan AschauerAndreas A. KammerlanderFranz DucaMarcus D. SäemannDiana BondermanJulia MascherbauerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marlies Antlanger Stefan Aschauer Andreas A. Kammerlander Franz Duca Marcus D. Säemann Diana Bonderman Julia Mascherbauer Impact of Systemic Volume Status on Cardiac Magnetic Resonance T1 Mapping
description	Abstract Diffuse myocardial fibrosis is a key pathophysiologic feature in heart failure and can be quantified by cardiac magnetic resonance (CMR) T1 mapping. However, increases in myocardial free water also prolong native T1 times and may impact fibrosis quantification. Thus far, the impact of systemic patient volume status remains unclear. In this study, native T1 time by CMR was investigated in hemodialysis (HD) patients (n = 37) and compared with healthy controls (n = 35). Volume status was quantified by bioimpedance spectroscopy and correlated with CMR T1 time. While no differences between HD patients and controls were present with regard to age (p = 0.180), height (p = 0.535), weight (p = 0.559) and left ventricular (LV) ejection fraction (p = 0.273), cardiac size was significantly larger in HD patients (LV end-diastolic volume 164 ± 53 vs. 132 ± 26 ml, p = 0.002). Fluid overloaded HD patients had significantly longer native T1 times than normovolemic HD patients and healthy controls (1,042 ± 46 vs. 1,005 ± 49 vs. 998 ± 47 ms, p = 0.030). By regression analysis, T1 time was significantly associated with fluid status (r = 0.530, p = 0.009, post-HD fluid status). Our data strongly indicate that native CMR T1 time is significantly influenced by systemic volume status. As fluid overload is common in patients with cardiovascular diseases, this finding is important and requires further study.
format	article
author	Marlies Antlanger Stefan Aschauer Andreas A. Kammerlander Franz Duca Marcus D. Säemann Diana Bonderman Julia Mascherbauer
author_facet	Marlies Antlanger Stefan Aschauer Andreas A. Kammerlander Franz Duca Marcus D. Säemann Diana Bonderman Julia Mascherbauer
author_sort	Marlies Antlanger
title	Impact of Systemic Volume Status on Cardiac Magnetic Resonance T1 Mapping
title_short	Impact of Systemic Volume Status on Cardiac Magnetic Resonance T1 Mapping
title_full	Impact of Systemic Volume Status on Cardiac Magnetic Resonance T1 Mapping
title_fullStr	Impact of Systemic Volume Status on Cardiac Magnetic Resonance T1 Mapping
title_full_unstemmed	Impact of Systemic Volume Status on Cardiac Magnetic Resonance T1 Mapping
title_sort	impact of systemic volume status on cardiac magnetic resonance t1 mapping
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/98e6796a5ec3461490d9419119e4af95
work_keys_str_mv	AT marliesantlanger impactofsystemicvolumestatusoncardiacmagneticresonancet1mapping AT stefanaschauer impactofsystemicvolumestatusoncardiacmagneticresonancet1mapping AT andreasakammerlander impactofsystemicvolumestatusoncardiacmagneticresonancet1mapping AT franzduca impactofsystemicvolumestatusoncardiacmagneticresonancet1mapping AT marcusdsaemann impactofsystemicvolumestatusoncardiacmagneticresonancet1mapping AT dianabonderman impactofsystemicvolumestatusoncardiacmagneticresonancet1mapping AT juliamascherbauer impactofsystemicvolumestatusoncardiacmagneticresonancet1mapping
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Impact of Systemic Volume Status on Cardiac Magnetic Resonance T1 Mapping

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