Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach

Oluwadamilare Falola,1 Victor Chukwudi Osamor,1,2 Marion Adebiyi,1,2 Ezekiel Adebiyi1,2 1Covenant University Bioinformatics Research (CUBRe), 2Department of Computer and Information Sciences, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria Background: Schizophrenia...

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Autores principales:	Falola O, Osamor VC, Adebiyi M, Adebiyi E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Meta-analysis Schizophrenia Single Nucleotide Polymorphism Heterogeneity Genetic variant Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/98e7c4b6300345b4a265b553f62fa6d9
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spelling	oai:doaj.org-article:98e7c4b6300345b4a265b553f62fa6d92021-12-02T08:55:23ZAnalyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach1178-2021https://doaj.org/article/98e7c4b6300345b4a265b553f62fa6d92017-08-01T00:00:00Zhttps://www.dovepress.com/analyzing--a-single-nucleotide-polymorphism-in-schizophrenia-a-meta-an-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Oluwadamilare Falola,1 Victor Chukwudi Osamor,1,2 Marion Adebiyi,1,2 Ezekiel Adebiyi1,2 1Covenant University Bioinformatics Research (CUBRe), 2Department of Computer and Information Sciences, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria Background: Schizophrenia is a severe mental disorder affecting >21 million people worldwide. Some genetic studies reported that single nucleotide polymorphism (SNP) involving variant rs1344706 from the ZNF804A gene in human beings is associated with the risk of schizophrenia in several populations. Similar results tend to conflict with other reports in literature, indicating that no true significant association exists between rs1344706 and schizophrenia. We seek to determine the level of association of this SNP with schizophrenia in the Asian population using more recent genome-wide association study (GWAS) datasets. Methods: Applying a computational approach with inclusion of more recent GWAS datasets, we conducted a meta-analysis to examine the level of association of SNP rs1344706 and the risk of schizophrenia disorder among the Asian population constituting Chinese, Indonesians, Japanese, Kazakhs and Singaporeans. For a total of 21 genetic studies, including a total of 28,842 cases and 35,630 controls, regression analysis, publication bias, Cochran’s Q and I2 tests were performed. The DerSimonian and Laird random-effects model was used to assess the association of the genetic variant to schizophrenia. Leave-one-out sensitivity analysis was also conducted to determine the influence of each study on the final outcome of the association study. Results: Our summarized analysis for Asian population revealed a pooled odds ratio of 1.06, 95% confidence interval of 1.01–1.11 and two-tailed P-value of 0.0228. Our test for heterogeneity showed the presence of large heterogeneity (I2=53.44%, P =0.00207) and Egger’s regression test (P =0.8763) and Begg’s test (P =0.8347), indicating no presence of publication bias among our selected studies. In our sensitivity analysis, 10 different studies comprising of ~50% of the entire study had an impact on our final results as each leave-one-out test became insignificant. Our result suggests that genetic variant rs1344706 might be associated with the development of schizophrenia in Asians. Keywords: meta-analysis, schizophrenia, single nucleotide polymorphism, heterogeneity, genetic variantFalola OOsamor VCAdebiyi MAdebiyi EDove Medical PressarticleMeta-analysisSchizophreniaSingle Nucleotide PolymorphismHeterogeneityGenetic variantNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2243-2250 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Meta-analysis Schizophrenia Single Nucleotide Polymorphism Heterogeneity Genetic variant Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Meta-analysis Schizophrenia Single Nucleotide Polymorphism Heterogeneity Genetic variant Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Falola O Osamor VC Adebiyi M Adebiyi E Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach
description	Oluwadamilare Falola,1 Victor Chukwudi Osamor,1,2 Marion Adebiyi,1,2 Ezekiel Adebiyi1,2 1Covenant University Bioinformatics Research (CUBRe), 2Department of Computer and Information Sciences, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria Background: Schizophrenia is a severe mental disorder affecting >21 million people worldwide. Some genetic studies reported that single nucleotide polymorphism (SNP) involving variant rs1344706 from the ZNF804A gene in human beings is associated with the risk of schizophrenia in several populations. Similar results tend to conflict with other reports in literature, indicating that no true significant association exists between rs1344706 and schizophrenia. We seek to determine the level of association of this SNP with schizophrenia in the Asian population using more recent genome-wide association study (GWAS) datasets. Methods: Applying a computational approach with inclusion of more recent GWAS datasets, we conducted a meta-analysis to examine the level of association of SNP rs1344706 and the risk of schizophrenia disorder among the Asian population constituting Chinese, Indonesians, Japanese, Kazakhs and Singaporeans. For a total of 21 genetic studies, including a total of 28,842 cases and 35,630 controls, regression analysis, publication bias, Cochran’s Q and I2 tests were performed. The DerSimonian and Laird random-effects model was used to assess the association of the genetic variant to schizophrenia. Leave-one-out sensitivity analysis was also conducted to determine the influence of each study on the final outcome of the association study. Results: Our summarized analysis for Asian population revealed a pooled odds ratio of 1.06, 95% confidence interval of 1.01–1.11 and two-tailed P-value of 0.0228. Our test for heterogeneity showed the presence of large heterogeneity (I2=53.44%, P =0.00207) and Egger’s regression test (P =0.8763) and Begg’s test (P =0.8347), indicating no presence of publication bias among our selected studies. In our sensitivity analysis, 10 different studies comprising of ~50% of the entire study had an impact on our final results as each leave-one-out test became insignificant. Our result suggests that genetic variant rs1344706 might be associated with the development of schizophrenia in Asians. Keywords: meta-analysis, schizophrenia, single nucleotide polymorphism, heterogeneity, genetic variant
format	article
author	Falola O Osamor VC Adebiyi M Adebiyi E
author_facet	Falola O Osamor VC Adebiyi M Adebiyi E
author_sort	Falola O
title	Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach
title_short	Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach
title_full	Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach
title_fullStr	Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach
title_full_unstemmed	Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach
title_sort	analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/98e7c4b6300345b4a265b553f62fa6d9
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Analyzing a single nucleotide polymorphism in schizophrenia: a meta-analysis approach

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