Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers

Objectives The aims of this study were to investigate the expression of Yes-associated protein 1 (YAP1), its prognostic significance, and the correlation between YAP1 and telomerase in various cancers. Methods The Gene Expression Profiling Interactive Analysis database was used to analyze RNA sequen...

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Autores principales:	Hye-Ran Kim, Choong-Won Seo, Keunje Yoo, Sang Jun Han, Jongwan Kim
Formato:	article
Lenguaje:	EN
Publicado:	Korea Centers for Disease Control & Prevention 2021
Materias:	correlation study neoplasms prognosis telomerase telomerase rna yes-associated protein 1 Special situations and conditions RC952-1245 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/98e7dcadd6bc47668dc362e749d5182f
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spelling	oai:doaj.org-article:98e7dcadd6bc47668dc362e749d5182f2021-11-05T00:07:51ZYes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers2210-90992210-911010.24171/j.phrp.2021.0207https://doaj.org/article/98e7dcadd6bc47668dc362e749d5182f2021-10-01T00:00:00Zhttp://ophrp.org/upload/pdf/j-phrp-2021-0207.pdfhttps://doaj.org/toc/2210-9099https://doaj.org/toc/2210-9110Objectives The aims of this study were to investigate the expression of Yes-associated protein 1 (YAP1), its prognostic significance, and the correlation between YAP1 and telomerase in various cancers. Methods The Gene Expression Profiling Interactive Analysis database was used to analyze RNA sequencing data and the survival rate of patients with various cancers in The Cancer Genome Atlas (TCGA) database. PrognoScan was used to analyze the prognostic value of YAP1 expression in various cancers. Tumor Immune Estimation Resource was used to determine the correlation between YAP1 expression and telomerase in various cancer types based on TCGA data. Results The analysis suggested that YAP1 was differentially expressed between tissues of various cancers and non-tumor tissues. High YAP1 expression was also related to a poor prognosis in adrenocortical carcinoma, bladder urothelial carcinoma, and pancreatic adenocarcinoma. Moreover, YAP1 expression was correlated with the expression of telomerase reverse transcriptase and telomerase RNA component in various cancer types. Conclusion These results suggest that YAP1 is a potential biomarker with prognostic significance and relevance for oncogene research in various cancer types. The correlation between the expression of YAP1 and telomere-associated genes will help to understand their cancer-promoting mechanisms and interactions.Hye-Ran KimChoong-Won SeoKeunje YooSang Jun HanJongwan KimKorea Centers for Disease Control & Preventionarticlecorrelation studyneoplasmsprognosistelomerasetelomerase rnayes-associated protein 1Special situations and conditionsRC952-1245Infectious and parasitic diseasesRC109-216ENOsong Public Health and Research Perspectives, Vol 12, Iss 5, Pp 324-332 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	correlation study neoplasms prognosis telomerase telomerase rna yes-associated protein 1 Special situations and conditions RC952-1245 Infectious and parasitic diseases RC109-216
spellingShingle	correlation study neoplasms prognosis telomerase telomerase rna yes-associated protein 1 Special situations and conditions RC952-1245 Infectious and parasitic diseases RC109-216 Hye-Ran Kim Choong-Won Seo Keunje Yoo Sang Jun Han Jongwan Kim Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers
description	Objectives The aims of this study were to investigate the expression of Yes-associated protein 1 (YAP1), its prognostic significance, and the correlation between YAP1 and telomerase in various cancers. Methods The Gene Expression Profiling Interactive Analysis database was used to analyze RNA sequencing data and the survival rate of patients with various cancers in The Cancer Genome Atlas (TCGA) database. PrognoScan was used to analyze the prognostic value of YAP1 expression in various cancers. Tumor Immune Estimation Resource was used to determine the correlation between YAP1 expression and telomerase in various cancer types based on TCGA data. Results The analysis suggested that YAP1 was differentially expressed between tissues of various cancers and non-tumor tissues. High YAP1 expression was also related to a poor prognosis in adrenocortical carcinoma, bladder urothelial carcinoma, and pancreatic adenocarcinoma. Moreover, YAP1 expression was correlated with the expression of telomerase reverse transcriptase and telomerase RNA component in various cancer types. Conclusion These results suggest that YAP1 is a potential biomarker with prognostic significance and relevance for oncogene research in various cancer types. The correlation between the expression of YAP1 and telomere-associated genes will help to understand their cancer-promoting mechanisms and interactions.
format	article
author	Hye-Ran Kim Choong-Won Seo Keunje Yoo Sang Jun Han Jongwan Kim
author_facet	Hye-Ran Kim Choong-Won Seo Keunje Yoo Sang Jun Han Jongwan Kim
author_sort	Hye-Ran Kim
title	Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers
title_short	Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers
title_full	Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers
title_fullStr	Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers
title_full_unstemmed	Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers
title_sort	yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers
publisher	Korea Centers for Disease Control & Prevention
publishDate	2021
url	https://doaj.org/article/98e7dcadd6bc47668dc362e749d5182f
work_keys_str_mv	AT hyerankim yesassociatedprotein1asaprognosticbiomarkeranditscorrelationwithtelomeraseinvariouscancers AT choongwonseo yesassociatedprotein1asaprognosticbiomarkeranditscorrelationwithtelomeraseinvariouscancers AT keunjeyoo yesassociatedprotein1asaprognosticbiomarkeranditscorrelationwithtelomeraseinvariouscancers AT sangjunhan yesassociatedprotein1asaprognosticbiomarkeranditscorrelationwithtelomeraseinvariouscancers AT jongwankim yesassociatedprotein1asaprognosticbiomarkeranditscorrelationwithtelomeraseinvariouscancers
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Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers

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