Forty-year prognosis after plaque brachytherapy of uveal melanoma
Abstract In this study, the long-term patient survival after plaque brachytherapy of uveal melanoma is examined. All patients treated between 1980 and 1999 at a single institution were included (n = 677). 533 (79%) had deceased before the end of follow-up. The median follow-up for the 144 survivors...
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Nature Portfolio
2020
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oai:doaj.org-article:98ecd82fb1a14ba980cc135fdf0139892021-12-02T15:39:48ZForty-year prognosis after plaque brachytherapy of uveal melanoma10.1038/s41598-020-68232-72045-2322https://doaj.org/article/98ecd82fb1a14ba980cc135fdf0139892020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-68232-7https://doaj.org/toc/2045-2322Abstract In this study, the long-term patient survival after plaque brachytherapy of uveal melanoma is examined. All patients treated between 1980 and 1999 at a single institution were included (n = 677). 533 (79%) had deceased before the end of follow-up. The median follow-up for the 144 survivors was 25.4 years (SD 5.2). Uveal melanoma-related mortality was 18% by 5 years, 28% by 10 years, 32% by 15 years, 35% by 20 years, and 36% by 25 to 40 years. 172 of 209 (82%) uveal melanoma-related deaths occurred within the first decade after brachytherapy. Relative survival rates were 74% at 5 years, 64% at 10 years, 62% at 20 years, 83% at 30 years and ≥100% at 32 to 40 years. Tumor diameter and local recurrence were independent predictors of uveal melanoma-related mortality in multivariate Cox proportional hazards analysis. In conclusion, uveal melanoma has a high mortality rate and most uveal melanoma-related deaths occur in the first decade after treatment. Long-term survivors may have a survival advantage to individuals of the same sex and age from the general population.Gustav StålhammarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) |
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Medicine R Science Q Gustav Stålhammar Forty-year prognosis after plaque brachytherapy of uveal melanoma |
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Abstract In this study, the long-term patient survival after plaque brachytherapy of uveal melanoma is examined. All patients treated between 1980 and 1999 at a single institution were included (n = 677). 533 (79%) had deceased before the end of follow-up. The median follow-up for the 144 survivors was 25.4 years (SD 5.2). Uveal melanoma-related mortality was 18% by 5 years, 28% by 10 years, 32% by 15 years, 35% by 20 years, and 36% by 25 to 40 years. 172 of 209 (82%) uveal melanoma-related deaths occurred within the first decade after brachytherapy. Relative survival rates were 74% at 5 years, 64% at 10 years, 62% at 20 years, 83% at 30 years and ≥100% at 32 to 40 years. Tumor diameter and local recurrence were independent predictors of uveal melanoma-related mortality in multivariate Cox proportional hazards analysis. In conclusion, uveal melanoma has a high mortality rate and most uveal melanoma-related deaths occur in the first decade after treatment. Long-term survivors may have a survival advantage to individuals of the same sex and age from the general population. |
| format |
article |
| author |
Gustav Stålhammar |
| author_facet |
Gustav Stålhammar |
| author_sort |
Gustav Stålhammar |
| title |
Forty-year prognosis after plaque brachytherapy of uveal melanoma |
| title_short |
Forty-year prognosis after plaque brachytherapy of uveal melanoma |
| title_full |
Forty-year prognosis after plaque brachytherapy of uveal melanoma |
| title_fullStr |
Forty-year prognosis after plaque brachytherapy of uveal melanoma |
| title_full_unstemmed |
Forty-year prognosis after plaque brachytherapy of uveal melanoma |
| title_sort |
forty-year prognosis after plaque brachytherapy of uveal melanoma |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/98ecd82fb1a14ba980cc135fdf013989 |
| work_keys_str_mv |
AT gustavstalhammar fortyyearprognosisafterplaquebrachytherapyofuvealmelanoma |
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1718385887800197120 |