GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. Here the authors demonstrate that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to ant...

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Autores principales:	Yapeng Li, Junfeng Gao, Mohammad Kamran, Laura Harmacek, Thomas Danhorn, Sonia M. Leach, Brian P. O’Connor, James R. Hagman, Hua Huang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98ed13f7bcd445fca8318b9df4898a0f
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spelling	oai:doaj.org-article:98ed13f7bcd445fca8318b9df4898a0f2021-12-02T13:51:03ZGATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers10.1038/s41467-020-20766-02041-1723https://doaj.org/article/98ed13f7bcd445fca8318b9df4898a0f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20766-0https://doaj.org/toc/2041-1723Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. Here the authors demonstrate that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to antigenic stimulation.Yapeng LiJunfeng GaoMohammad KamranLaura HarmacekThomas DanhornSonia M. LeachBrian P. O’ConnorJames R. HagmanHua HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yapeng Li Junfeng Gao Mohammad Kamran Laura Harmacek Thomas Danhorn Sonia M. Leach Brian P. O’Connor James R. Hagman Hua Huang GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
description	Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. Here the authors demonstrate that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to antigenic stimulation.
format	article
author	Yapeng Li Junfeng Gao Mohammad Kamran Laura Harmacek Thomas Danhorn Sonia M. Leach Brian P. O’Connor James R. Hagman Hua Huang
author_facet	Yapeng Li Junfeng Gao Mohammad Kamran Laura Harmacek Thomas Danhorn Sonia M. Leach Brian P. O’Connor James R. Hagman Hua Huang
author_sort	Yapeng Li
title	GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
title_short	GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
title_full	GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
title_fullStr	GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
title_full_unstemmed	GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
title_sort	gata2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/98ed13f7bcd445fca8318b9df4898a0f
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GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

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