Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia

CAR T therapy has some efficacy in the treatment of patients with refractory/relapsed B-cell acute lymphoblastic leukemia; however in some patients further relapse is encountered. Here, the authors conduct a Phase II clinical trial of a CD19 CAR T and demonstrate that patients with extramedullary di...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Furun An, Huiping Wang, Zhenyun Liu, Fan Wu, Jiakui Zhang, Qianshan Tao, Yingwei Li, Yuanyuan Shen, Yanjie Ruan, Qing Zhang, Ying Pan, Weiwei Zhu, Hui Qin, Yansheng Wang, Yongling Fu, Zhenqing Feng, Zhimin Zhai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Q
Acceso en línea:https://doaj.org/article/98edec5e9e1b40fba202ff27a9aef3a1
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:98edec5e9e1b40fba202ff27a9aef3a1
record_format dspace
spelling oai:doaj.org-article:98edec5e9e1b40fba202ff27a9aef3a12021-12-02T13:27:23ZInfluence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia10.1038/s41467-020-19774-x2041-1723https://doaj.org/article/98edec5e9e1b40fba202ff27a9aef3a12020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19774-xhttps://doaj.org/toc/2041-1723CAR T therapy has some efficacy in the treatment of patients with refractory/relapsed B-cell acute lymphoblastic leukemia; however in some patients further relapse is encountered. Here, the authors conduct a Phase II clinical trial of a CD19 CAR T and demonstrate that patients with extramedullary disease are more likely to relapse than those without.Furun AnHuiping WangZhenyun LiuFan WuJiakui ZhangQianshan TaoYingwei LiYuanyuan ShenYanjie RuanQing ZhangYing PanWeiwei ZhuHui QinYansheng WangYongling FuZhenqing FengZhimin ZhaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Furun An
Huiping Wang
Zhenyun Liu
Fan Wu
Jiakui Zhang
Qianshan Tao
Yingwei Li
Yuanyuan Shen
Yanjie Ruan
Qing Zhang
Ying Pan
Weiwei Zhu
Hui Qin
Yansheng Wang
Yongling Fu
Zhenqing Feng
Zhimin Zhai
Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
description CAR T therapy has some efficacy in the treatment of patients with refractory/relapsed B-cell acute lymphoblastic leukemia; however in some patients further relapse is encountered. Here, the authors conduct a Phase II clinical trial of a CD19 CAR T and demonstrate that patients with extramedullary disease are more likely to relapse than those without.
format article
author Furun An
Huiping Wang
Zhenyun Liu
Fan Wu
Jiakui Zhang
Qianshan Tao
Yingwei Li
Yuanyuan Shen
Yanjie Ruan
Qing Zhang
Ying Pan
Weiwei Zhu
Hui Qin
Yansheng Wang
Yongling Fu
Zhenqing Feng
Zhimin Zhai
author_facet Furun An
Huiping Wang
Zhenyun Liu
Fan Wu
Jiakui Zhang
Qianshan Tao
Yingwei Li
Yuanyuan Shen
Yanjie Ruan
Qing Zhang
Ying Pan
Weiwei Zhu
Hui Qin
Yansheng Wang
Yongling Fu
Zhenqing Feng
Zhimin Zhai
author_sort Furun An
title Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
title_short Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
title_full Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
title_fullStr Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
title_full_unstemmed Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
title_sort influence of patient characteristics on chimeric antigen receptor t cell therapy in b-cell acute lymphoblastic leukemia
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/98edec5e9e1b40fba202ff27a9aef3a1
work_keys_str_mv AT furunan influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT huipingwang influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT zhenyunliu influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT fanwu influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT jiakuizhang influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT qianshantao influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT yingweili influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT yuanyuanshen influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT yanjieruan influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT qingzhang influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT yingpan influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT weiweizhu influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT huiqin influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT yanshengwang influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT yonglingfu influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT zhenqingfeng influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
AT zhiminzhai influenceofpatientcharacteristicsonchimericantigenreceptortcelltherapyinbcellacutelymphoblasticleukemia
_version_ 1718392990751260672