Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia

CAR T therapy has some efficacy in the treatment of patients with refractory/relapsed B-cell acute lymphoblastic leukemia; however in some patients further relapse is encountered. Here, the authors conduct a Phase II clinical trial of a CD19 CAR T and demonstrate that patients with extramedullary di...

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Main Authors:	Furun An, Huiping Wang, Zhenyun Liu, Fan Wu, Jiakui Zhang, Qianshan Tao, Yingwei Li, Yuanyuan Shen, Yanjie Ruan, Qing Zhang, Ying Pan, Weiwei Zhu, Hui Qin, Yansheng Wang, Yongling Fu, Zhenqing Feng, Zhimin Zhai
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/98edec5e9e1b40fba202ff27a9aef3a1
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spelling	oai:doaj.org-article:98edec5e9e1b40fba202ff27a9aef3a12021-12-02T13:27:23ZInfluence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia10.1038/s41467-020-19774-x2041-1723https://doaj.org/article/98edec5e9e1b40fba202ff27a9aef3a12020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19774-xhttps://doaj.org/toc/2041-1723CAR T therapy has some efficacy in the treatment of patients with refractory/relapsed B-cell acute lymphoblastic leukemia; however in some patients further relapse is encountered. Here, the authors conduct a Phase II clinical trial of a CD19 CAR T and demonstrate that patients with extramedullary disease are more likely to relapse than those without.Furun AnHuiping WangZhenyun LiuFan WuJiakui ZhangQianshan TaoYingwei LiYuanyuan ShenYanjie RuanQing ZhangYing PanWeiwei ZhuHui QinYansheng WangYongling FuZhenqing FengZhimin ZhaiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Furun An Huiping Wang Zhenyun Liu Fan Wu Jiakui Zhang Qianshan Tao Yingwei Li Yuanyuan Shen Yanjie Ruan Qing Zhang Ying Pan Weiwei Zhu Hui Qin Yansheng Wang Yongling Fu Zhenqing Feng Zhimin Zhai Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
description	CAR T therapy has some efficacy in the treatment of patients with refractory/relapsed B-cell acute lymphoblastic leukemia; however in some patients further relapse is encountered. Here, the authors conduct a Phase II clinical trial of a CD19 CAR T and demonstrate that patients with extramedullary disease are more likely to relapse than those without.
format	article
author	Furun An Huiping Wang Zhenyun Liu Fan Wu Jiakui Zhang Qianshan Tao Yingwei Li Yuanyuan Shen Yanjie Ruan Qing Zhang Ying Pan Weiwei Zhu Hui Qin Yansheng Wang Yongling Fu Zhenqing Feng Zhimin Zhai
author_facet	Furun An Huiping Wang Zhenyun Liu Fan Wu Jiakui Zhang Qianshan Tao Yingwei Li Yuanyuan Shen Yanjie Ruan Qing Zhang Ying Pan Weiwei Zhu Hui Qin Yansheng Wang Yongling Fu Zhenqing Feng Zhimin Zhai
author_sort	Furun An
title	Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
title_short	Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
title_full	Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
title_fullStr	Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
title_full_unstemmed	Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia
title_sort	influence of patient characteristics on chimeric antigen receptor t cell therapy in b-cell acute lymphoblastic leukemia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/98edec5e9e1b40fba202ff27a9aef3a1
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Influence of patient characteristics on chimeric antigen receptor T cell therapy in B-cell acute lymphoblastic leukemia

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