Nosocomial infections amongst critically ill COVID-19 patients in Australia

Purpose: To determine the frequency of nosocomial infections including hospital-acquired pneumonia (HAP) and bloodstream infection (BSI), amongst critically ill patients with COVID-19 infection in Australian ICUs and to evaluate associations with mortality and length of stay (LOS). Methods: The effe...

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Autores principales:	Mahesh Ramanan, Aidan Burrell, Eldho Paul, Tony Trapani, Tessa Broadley, Steve McGloughlin, Craig French, Andrew Udy
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	COVID-19 Critical care Bloodstream infections Nosocomial infections Healthcare-associated pneumonia Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/98ef3d0f0e7a474997041c64b84007e0
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spelling	oai:doaj.org-article:98ef3d0f0e7a474997041c64b84007e02021-11-20T05:16:00ZNosocomial infections amongst critically ill COVID-19 patients in Australia2667-038010.1016/j.jcvp.2021.100054https://doaj.org/article/98ef3d0f0e7a474997041c64b84007e02021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667038021000466https://doaj.org/toc/2667-0380Purpose: To determine the frequency of nosocomial infections including hospital-acquired pneumonia (HAP) and bloodstream infection (BSI), amongst critically ill patients with COVID-19 infection in Australian ICUs and to evaluate associations with mortality and length of stay (LOS). Methods: The effect of nosocomial infections on hospital mortality was evaluated using hierarchical logistic regression models to adjust for illness severity and mechanical ventilation. Results: There were 490 patients admitted to 55 ICUs during the study period. Adjusted odds ratio (OR) for hospital mortality was 1.61 (95% confidence interval (CI) 0.61–4.27, p = 0.3) when considering BSI, and 1.76 (95% CI 0.73–4.21, p = 0.2) for HAP. The average adjusted ICU LOS was significantly longer for patients with BSI (geometric mean 9.0 days vs 6.3 days, p = 0.04) and HAP (geometric mean 13.9 days vs 6.0 days p<0.001). Conclusion: Nosocomial infection rates amongst patients with COVID-19 were low and their development was associated with a significantly longer ICU LOS.Mahesh RamananAidan BurrellEldho PaulTony TrapaniTessa BroadleySteve McGloughlinCraig FrenchAndrew UdyElsevierarticleCOVID-19Critical careBloodstream infectionsNosocomial infectionsHealthcare-associated pneumoniaInfectious and parasitic diseasesRC109-216ENJournal of Clinical Virology Plus, Vol 1, Iss 4, Pp 100054- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Critical care Bloodstream infections Nosocomial infections Healthcare-associated pneumonia Infectious and parasitic diseases RC109-216
spellingShingle	COVID-19 Critical care Bloodstream infections Nosocomial infections Healthcare-associated pneumonia Infectious and parasitic diseases RC109-216 Mahesh Ramanan Aidan Burrell Eldho Paul Tony Trapani Tessa Broadley Steve McGloughlin Craig French Andrew Udy Nosocomial infections amongst critically ill COVID-19 patients in Australia
description	Purpose: To determine the frequency of nosocomial infections including hospital-acquired pneumonia (HAP) and bloodstream infection (BSI), amongst critically ill patients with COVID-19 infection in Australian ICUs and to evaluate associations with mortality and length of stay (LOS). Methods: The effect of nosocomial infections on hospital mortality was evaluated using hierarchical logistic regression models to adjust for illness severity and mechanical ventilation. Results: There were 490 patients admitted to 55 ICUs during the study period. Adjusted odds ratio (OR) for hospital mortality was 1.61 (95% confidence interval (CI) 0.61–4.27, p = 0.3) when considering BSI, and 1.76 (95% CI 0.73–4.21, p = 0.2) for HAP. The average adjusted ICU LOS was significantly longer for patients with BSI (geometric mean 9.0 days vs 6.3 days, p = 0.04) and HAP (geometric mean 13.9 days vs 6.0 days p<0.001). Conclusion: Nosocomial infection rates amongst patients with COVID-19 were low and their development was associated with a significantly longer ICU LOS.
format	article
author	Mahesh Ramanan Aidan Burrell Eldho Paul Tony Trapani Tessa Broadley Steve McGloughlin Craig French Andrew Udy
author_facet	Mahesh Ramanan Aidan Burrell Eldho Paul Tony Trapani Tessa Broadley Steve McGloughlin Craig French Andrew Udy
author_sort	Mahesh Ramanan
title	Nosocomial infections amongst critically ill COVID-19 patients in Australia
title_short	Nosocomial infections amongst critically ill COVID-19 patients in Australia
title_full	Nosocomial infections amongst critically ill COVID-19 patients in Australia
title_fullStr	Nosocomial infections amongst critically ill COVID-19 patients in Australia
title_full_unstemmed	Nosocomial infections amongst critically ill COVID-19 patients in Australia
title_sort	nosocomial infections amongst critically ill covid-19 patients in australia
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/98ef3d0f0e7a474997041c64b84007e0
work_keys_str_mv	AT maheshramanan nosocomialinfectionsamongstcriticallyillcovid19patientsinaustralia AT aidanburrell nosocomialinfectionsamongstcriticallyillcovid19patientsinaustralia AT eldhopaul nosocomialinfectionsamongstcriticallyillcovid19patientsinaustralia AT tonytrapani nosocomialinfectionsamongstcriticallyillcovid19patientsinaustralia AT tessabroadley nosocomialinfectionsamongstcriticallyillcovid19patientsinaustralia AT stevemcgloughlin nosocomialinfectionsamongstcriticallyillcovid19patientsinaustralia AT craigfrench nosocomialinfectionsamongstcriticallyillcovid19patientsinaustralia AT andrewudy nosocomialinfectionsamongstcriticallyillcovid19patientsinaustralia
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Nosocomial infections amongst critically ill COVID-19 patients in Australia

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