Poly(Lactic Acid)/Graphite Nanoplatelet Nanocomposite Filaments for Ligament Scaffolds

The anterior cruciate ligament (ACL) is one of the most prone to injury in the human body. Due to its insufficient vascularization and low regenerative capacity, surgery is often required when it is ruptured. Most of the current tissue engineering (TE) strategies are based on scaffolds produced with...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Magda Silva, Carina Gomes, Isabel Pinho, Hugo Gonçalves, Ana C. Vale, José A. Covas, Natália M. Alves, Maria C. Paiva
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ligament biomedical applications composites 3D-printed scaffold textile-engineered scaffold functionalized graphene Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/98f5e5d4c8834bfb9002ebd7c879f1e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:98f5e5d4c8834bfb9002ebd7c879f1e7
record_format	dspace
spelling	oai:doaj.org-article:98f5e5d4c8834bfb9002ebd7c879f1e72021-11-25T18:29:53ZPoly(Lactic Acid)/Graphite Nanoplatelet Nanocomposite Filaments for Ligament Scaffolds10.3390/nano111127962079-4991https://doaj.org/article/98f5e5d4c8834bfb9002ebd7c879f1e72021-10-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2796https://doaj.org/toc/2079-4991The anterior cruciate ligament (ACL) is one of the most prone to injury in the human body. Due to its insufficient vascularization and low regenerative capacity, surgery is often required when it is ruptured. Most of the current tissue engineering (TE) strategies are based on scaffolds produced with fibers due to the natural ligament’s fibrous structure. In the present work, composite filaments based on poly(L-lactic acid) (PLA) reinforced with graphite nanoplatelets (PLA+EG) as received, chemically functionalized (PLA+f-EG), or functionalized and decorated with silver nanoparticles [PLA+((f-EG)+Ag)] were produced by melt mixing, ensuring good filler dispersion. These filaments were produced with diameters of 0.25 mm and 1.75 mm for textile-engineered and 3D-printed ligament scaffolds, respectively. The resulting composite filaments are thermally stable, and the incorporation of graphite increases the stiffness of the composites and decreases the electrical resistivity, as compared to PLA. None of the filaments suffered significant degradation after 27 days. The composite filaments were processed into 3D scaffolds with finely controlled dimensions and porosity by textile-engineered and additive fabrication techniques, demonstrating their potential for ligament TE applications.Magda SilvaCarina GomesIsabel PinhoHugo GonçalvesAna C. ValeJosé A. CovasNatália M. AlvesMaria C. PaivaMDPI AGarticleligamentbiomedical applicationscomposites3D-printed scaffoldtextile-engineered scaffoldfunctionalized grapheneChemistryQD1-999ENNanomaterials, Vol 11, Iss 2796, p 2796 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ligament biomedical applications composites 3D-printed scaffold textile-engineered scaffold functionalized graphene Chemistry QD1-999
spellingShingle	ligament biomedical applications composites 3D-printed scaffold textile-engineered scaffold functionalized graphene Chemistry QD1-999 Magda Silva Carina Gomes Isabel Pinho Hugo Gonçalves Ana C. Vale José A. Covas Natália M. Alves Maria C. Paiva Poly(Lactic Acid)/Graphite Nanoplatelet Nanocomposite Filaments for Ligament Scaffolds
description	The anterior cruciate ligament (ACL) is one of the most prone to injury in the human body. Due to its insufficient vascularization and low regenerative capacity, surgery is often required when it is ruptured. Most of the current tissue engineering (TE) strategies are based on scaffolds produced with fibers due to the natural ligament’s fibrous structure. In the present work, composite filaments based on poly(L-lactic acid) (PLA) reinforced with graphite nanoplatelets (PLA+EG) as received, chemically functionalized (PLA+f-EG), or functionalized and decorated with silver nanoparticles [PLA+((f-EG)+Ag)] were produced by melt mixing, ensuring good filler dispersion. These filaments were produced with diameters of 0.25 mm and 1.75 mm for textile-engineered and 3D-printed ligament scaffolds, respectively. The resulting composite filaments are thermally stable, and the incorporation of graphite increases the stiffness of the composites and decreases the electrical resistivity, as compared to PLA. None of the filaments suffered significant degradation after 27 days. The composite filaments were processed into 3D scaffolds with finely controlled dimensions and porosity by textile-engineered and additive fabrication techniques, demonstrating their potential for ligament TE applications.
format	article
author	Magda Silva Carina Gomes Isabel Pinho Hugo Gonçalves Ana C. Vale José A. Covas Natália M. Alves Maria C. Paiva
author_facet	Magda Silva Carina Gomes Isabel Pinho Hugo Gonçalves Ana C. Vale José A. Covas Natália M. Alves Maria C. Paiva
author_sort	Magda Silva
title	Poly(Lactic Acid)/Graphite Nanoplatelet Nanocomposite Filaments for Ligament Scaffolds
title_short	Poly(Lactic Acid)/Graphite Nanoplatelet Nanocomposite Filaments for Ligament Scaffolds
title_full	Poly(Lactic Acid)/Graphite Nanoplatelet Nanocomposite Filaments for Ligament Scaffolds
title_fullStr	Poly(Lactic Acid)/Graphite Nanoplatelet Nanocomposite Filaments for Ligament Scaffolds
title_full_unstemmed	Poly(Lactic Acid)/Graphite Nanoplatelet Nanocomposite Filaments for Ligament Scaffolds
title_sort	poly(lactic acid)/graphite nanoplatelet nanocomposite filaments for ligament scaffolds
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/98f5e5d4c8834bfb9002ebd7c879f1e7
work_keys_str_mv	AT magdasilva polylacticacidgraphitenanoplateletnanocompositefilamentsforligamentscaffolds AT carinagomes polylacticacidgraphitenanoplateletnanocompositefilamentsforligamentscaffolds AT isabelpinho polylacticacidgraphitenanoplateletnanocompositefilamentsforligamentscaffolds AT hugogoncalves polylacticacidgraphitenanoplateletnanocompositefilamentsforligamentscaffolds AT anacvale polylacticacidgraphitenanoplateletnanocompositefilamentsforligamentscaffolds AT joseacovas polylacticacidgraphitenanoplateletnanocompositefilamentsforligamentscaffolds AT nataliamalves polylacticacidgraphitenanoplateletnanocompositefilamentsforligamentscaffolds AT mariacpaiva polylacticacidgraphitenanoplateletnanocompositefilamentsforligamentscaffolds
_version_	1718411092183482368

Poly(Lactic Acid)/Graphite Nanoplatelet Nanocomposite Filaments for Ligament Scaffolds

Ejemplares similares