Lactobacillus plantarum C29 alleviates NF-κB activation and Th17/Treg imbalance in mice with TNBS-induced colitis
In this study, we examined whether Lactobacillus plantarum C29 could restore 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced T helper 17 (Th17)/regulatory T cells (Tregs) imbalance in mice. Treatment with C29 inhibited the differentiation of splenic T cells into Th17 cells and the expression of re...
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2018
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oai:doaj.org-article:98f73420ccf641d49622f6588f2edc932021-11-26T11:19:46ZLactobacillus plantarum C29 alleviates NF-κB activation and Th17/Treg imbalance in mice with TNBS-induced colitis0954-01051465-344310.1080/09540105.2017.1418841https://doaj.org/article/98f73420ccf641d49622f6588f2edc932018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2017.1418841https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443In this study, we examined whether Lactobacillus plantarum C29 could restore 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced T helper 17 (Th17)/regulatory T cells (Tregs) imbalance in mice. Treatment with C29 inhibited the differentiation of splenic T cells into Th17 cells and the expression of retinoic acid receptor-related orphan receptor gamma t (RORγt) and IL-17 in vitro, whereas promoting the differentiation into Tregs. Oral administration of Lactobacillus plantarum C29 in mice attenuated TNBS-induced colon shortening, myeloperoxidase (MPO) activity, inducible Nitric oxide (NO) synthase, and cyclooxygenase-2 expression, and activation of NF-κB in the colon of mice. C29 treatment downregulated TNF-α, IL-17, and IL-1β expression, while increasing IL-10 expression. C29 treatment suppressed TNBS-induced Th17 cell differentiation and reduced IL-17 and RORγt expression, while promoting the TNBS-suppressed Tregs differentiation and IL-10 and forkhead box P3 expression. These findings suggest that C29 can alleviate colitis by modulating NF-κB activation as well as Th17/Treg balance.Jin-Ju JeongHae-Ji LeeSe-Eun JangMyung Joo HanDong-Hyun KimTaylor & Francis Grouparticlelactobacillus plantarumcolitist cell differentiationAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 577-589 (2018) |
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lactobacillus plantarum colitis t cell differentiation Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 |
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lactobacillus plantarum colitis t cell differentiation Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Jin-Ju Jeong Hae-Ji Lee Se-Eun Jang Myung Joo Han Dong-Hyun Kim Lactobacillus plantarum C29 alleviates NF-κB activation and Th17/Treg imbalance in mice with TNBS-induced colitis |
| description |
In this study, we examined whether Lactobacillus plantarum C29 could restore 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced T helper 17 (Th17)/regulatory T cells (Tregs) imbalance in mice. Treatment with C29 inhibited the differentiation of splenic T cells into Th17 cells and the expression of retinoic acid receptor-related orphan receptor gamma t (RORγt) and IL-17 in vitro, whereas promoting the differentiation into Tregs. Oral administration of Lactobacillus plantarum C29 in mice attenuated TNBS-induced colon shortening, myeloperoxidase (MPO) activity, inducible Nitric oxide (NO) synthase, and cyclooxygenase-2 expression, and activation of NF-κB in the colon of mice. C29 treatment downregulated TNF-α, IL-17, and IL-1β expression, while increasing IL-10 expression. C29 treatment suppressed TNBS-induced Th17 cell differentiation and reduced IL-17 and RORγt expression, while promoting the TNBS-suppressed Tregs differentiation and IL-10 and forkhead box P3 expression. These findings suggest that C29 can alleviate colitis by modulating NF-κB activation as well as Th17/Treg balance. |
| format |
article |
| author |
Jin-Ju Jeong Hae-Ji Lee Se-Eun Jang Myung Joo Han Dong-Hyun Kim |
| author_facet |
Jin-Ju Jeong Hae-Ji Lee Se-Eun Jang Myung Joo Han Dong-Hyun Kim |
| author_sort |
Jin-Ju Jeong |
| title |
Lactobacillus plantarum C29 alleviates NF-κB activation and Th17/Treg imbalance in mice with TNBS-induced colitis |
| title_short |
Lactobacillus plantarum C29 alleviates NF-κB activation and Th17/Treg imbalance in mice with TNBS-induced colitis |
| title_full |
Lactobacillus plantarum C29 alleviates NF-κB activation and Th17/Treg imbalance in mice with TNBS-induced colitis |
| title_fullStr |
Lactobacillus plantarum C29 alleviates NF-κB activation and Th17/Treg imbalance in mice with TNBS-induced colitis |
| title_full_unstemmed |
Lactobacillus plantarum C29 alleviates NF-κB activation and Th17/Treg imbalance in mice with TNBS-induced colitis |
| title_sort |
lactobacillus plantarum c29 alleviates nf-κb activation and th17/treg imbalance in mice with tnbs-induced colitis |
| publisher |
Taylor & Francis Group |
| publishDate |
2018 |
| url |
https://doaj.org/article/98f73420ccf641d49622f6588f2edc93 |
| work_keys_str_mv |
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| _version_ |
1718409549402079232 |