Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here authors show that nucleoplasmic LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs and constitute a feedback mechanism to regulate PC synthesis in accordance with ER stress.

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Autores principales:	Kamil Sołtysik, Yuki Ohsaki, Tsuyako Tatematsu, Jinglei Cheng, Toyoshi Fujimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98f83579d492448e8f406580e20eef6d
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spelling	oai:doaj.org-article:98f83579d492448e8f406580e20eef6d2021-12-02T14:38:43ZNuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis10.1038/s41467-019-08411-x2041-1723https://doaj.org/article/98f83579d492448e8f406580e20eef6d2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08411-xhttps://doaj.org/toc/2041-1723The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here authors show that nucleoplasmic LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs and constitute a feedback mechanism to regulate PC synthesis in accordance with ER stress.Kamil SołtysikYuki OhsakiTsuyako TatematsuJinglei ChengToyoshi FujimotoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kamil Sołtysik Yuki Ohsaki Tsuyako Tatematsu Jinglei Cheng Toyoshi Fujimoto Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
description	The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here authors show that nucleoplasmic LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs and constitute a feedback mechanism to regulate PC synthesis in accordance with ER stress.
format	article
author	Kamil Sołtysik Yuki Ohsaki Tsuyako Tatematsu Jinglei Cheng Toyoshi Fujimoto
author_facet	Kamil Sołtysik Yuki Ohsaki Tsuyako Tatematsu Jinglei Cheng Toyoshi Fujimoto
author_sort	Kamil Sołtysik
title	Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
title_short	Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
title_full	Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
title_fullStr	Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
title_full_unstemmed	Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
title_sort	nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/98f83579d492448e8f406580e20eef6d
work_keys_str_mv	AT kamilsołtysik nuclearlipiddropletsderivefromalipoproteinprecursorandregulatephosphatidylcholinesynthesis AT yukiohsaki nuclearlipiddropletsderivefromalipoproteinprecursorandregulatephosphatidylcholinesynthesis AT tsuyakotatematsu nuclearlipiddropletsderivefromalipoproteinprecursorandregulatephosphatidylcholinesynthesis AT jingleicheng nuclearlipiddropletsderivefromalipoproteinprecursorandregulatephosphatidylcholinesynthesis AT toyoshifujimoto nuclearlipiddropletsderivefromalipoproteinprecursorandregulatephosphatidylcholinesynthesis
_version_	1718390909540761600

Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

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