Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.

<h4>Background</h4>No animal models of autism spectrum disorders (ASD) with good construct validity are currently available; using genetic models of pathologies characterized by ASD-like deficits, but with known causes, may be therefore a promising strategy. The Fmr1-KO mouse is an examp...

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Autores principales:	Susanna Pietropaolo, Aurélie Guilleminot, Benoît Martin, Francesca R D'Amato, Wim E Crusio
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/98faa50aed5a41228dba32b62467e45e
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spelling	oai:doaj.org-article:98faa50aed5a41228dba32b62467e45e2021-11-18T06:58:29ZGenetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.1932-620310.1371/journal.pone.0017073https://doaj.org/article/98faa50aed5a41228dba32b62467e45e2011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21364941/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>No animal models of autism spectrum disorders (ASD) with good construct validity are currently available; using genetic models of pathologies characterized by ASD-like deficits, but with known causes, may be therefore a promising strategy. The Fmr1-KO mouse is an example of this approach, modeling Fragile X syndrome, a well-known genetic disorder presenting ASD symptoms. The Fmr1-KO is available on different genetic backgrounds (FVB versus C57BL/6), which may explain some of the conflicting results that have been obtained with these mutants up till now.<h4>Methods</h4>Fmr1 KO and their wild-type littermates on both the FVB and C57BL/6 genetic backgrounds were examined on a battery of tests modeling the clinical symptoms of ASD, including the triad of core symptoms (alterations in social interaction and communication, presence of repetitive behaviors), as well as the secondary symptoms (disturbances in sensori-motor reactivity and in circadian patterns of activity, epileptic events).<h4>Results</h4>Fmr1-KO mice displayed autistic-like core symptoms of altered social interaction and occurrence of repetitive behaviors with additional hyperactivity. The genetic background modulated the effects of the Fmr1 deletion and it appears that the C57BL/6 background may be more suitable for further research on core autistic-like symptoms.<h4>Conclusions</h4>The Fmr1-mouse line does not recapitulate all of the main core and secondary ASD symptoms, but still can be useful to elucidate the neurobiological mechanisms underlying specific ASD-like endophenotypes.Susanna PietropaoloAurélie GuilleminotBenoît MartinFrancesca R D'AmatoWim E CrusioPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e17073 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susanna Pietropaolo Aurélie Guilleminot Benoît Martin Francesca R D'Amato Wim E Crusio Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.
description	<h4>Background</h4>No animal models of autism spectrum disorders (ASD) with good construct validity are currently available; using genetic models of pathologies characterized by ASD-like deficits, but with known causes, may be therefore a promising strategy. The Fmr1-KO mouse is an example of this approach, modeling Fragile X syndrome, a well-known genetic disorder presenting ASD symptoms. The Fmr1-KO is available on different genetic backgrounds (FVB versus C57BL/6), which may explain some of the conflicting results that have been obtained with these mutants up till now.<h4>Methods</h4>Fmr1 KO and their wild-type littermates on both the FVB and C57BL/6 genetic backgrounds were examined on a battery of tests modeling the clinical symptoms of ASD, including the triad of core symptoms (alterations in social interaction and communication, presence of repetitive behaviors), as well as the secondary symptoms (disturbances in sensori-motor reactivity and in circadian patterns of activity, epileptic events).<h4>Results</h4>Fmr1-KO mice displayed autistic-like core symptoms of altered social interaction and occurrence of repetitive behaviors with additional hyperactivity. The genetic background modulated the effects of the Fmr1 deletion and it appears that the C57BL/6 background may be more suitable for further research on core autistic-like symptoms.<h4>Conclusions</h4>The Fmr1-mouse line does not recapitulate all of the main core and secondary ASD symptoms, but still can be useful to elucidate the neurobiological mechanisms underlying specific ASD-like endophenotypes.
format	article
author	Susanna Pietropaolo Aurélie Guilleminot Benoît Martin Francesca R D'Amato Wim E Crusio
author_facet	Susanna Pietropaolo Aurélie Guilleminot Benoît Martin Francesca R D'Amato Wim E Crusio
author_sort	Susanna Pietropaolo
title	Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.
title_short	Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.
title_full	Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.
title_fullStr	Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.
title_full_unstemmed	Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.
title_sort	genetic-background modulation of core and variable autistic-like symptoms in fmr1 knock-out mice.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/98faa50aed5a41228dba32b62467e45e
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Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.

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