Extrahepatic metastases of hepatocellular carcinoma on 18F FDG PET CT

Abstract Background To determine locations, relative frequencies, imaging features, and pattern of distribution of extrahepatic metastasis from hepatocellular carcinoma (HCC) on 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG) PET CT. Methods FDG PET CT scans of 224 consecutive patients of HCC acqu...

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Autores principales:	Manjit Sarma, Subramanyam Padma, Parvathy Pavithran, Vijay Harish Somasundaram, Palanisamy Shanmuga Sundaram
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Hepatocellular carcinoma Extrahepatic metastasis FDG PET CT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/98fc680aa3904e8999637dd3aa454ed6
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spelling	oai:doaj.org-article:98fc680aa3904e8999637dd3aa454ed62021-11-28T12:08:05ZExtrahepatic metastases of hepatocellular carcinoma on 18F FDG PET CT10.1186/s43046-021-00086-02589-0409https://doaj.org/article/98fc680aa3904e8999637dd3aa454ed62021-11-01T00:00:00Zhttps://doi.org/10.1186/s43046-021-00086-0https://doaj.org/toc/2589-0409Abstract Background To determine locations, relative frequencies, imaging features, and pattern of distribution of extrahepatic metastasis from hepatocellular carcinoma (HCC) on 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG) PET CT. Methods FDG PET CT scans of 224 consecutive patients of HCC acquired between 2010 and 2018 were reviewed. Fifty-six patients detected with extrahepatic metastasis on FDG PET CT were retrospectively analyzed. Findings were correlated with prior/follow-up imaging studies, clinical findings, FNAC, or biopsy findings whenever available. Descriptive analysis of location, relative frequencies, imaging features, and pattern of distribution of extrahepatic metastasis was done. Results Commonest were metastatic pulmonary nodules (55.3% patients), most of them being well-defined solid lesions (53.5%) with bilateral involvement in 44.6% patients and lower lobes of lungs along with other lobes being more frequently involved (41.0% patients). While in 7.14% patients lung nodules were FDG avid, 23.2% patients had both FDG avid and non-avid pulmonary nodules. Second most common were regional metastatic lymph nodes in 44.65% of patients seen at aortocaval (25%), paraaortic (23.21%), portocaval (21.4%), and left gastric nodal (17.8% of patients) stations. Twenty-five percent of patients had FDG avid lymph nodes and 5.36% patients had both FDG avid and FDG non-avid lymph nodes. Distant metastatic lymph nodes were third most common in 39.2% of patients seen at paratracheal (2.5%), juxtaphrenic (8.9%), and mesenteric lymphnodal (7.1%) stations. Twenty-five percent of patients had FDG avid lymph nodes while 5.36% patients had both FDG avid and FDG non-avid lymph nodes. Skeletal involvement was seen in 32.1% of patients. Commonest sites are vertebrae (16.7%), pelvis (14.2%), and ribs (10.7% patients). Six out of 7 patients had unilateral adrenal gland involvement. Bilateral adrenal gland involvement was seen in 1 patient. FDG non-avid peritoneal/omental metastases was seen in 2 patients. Brain, spleen, and muscle metastatic lesions were seen in 1 patient each out of 56 patients (1.79%). Conclusions Lungs, regional and distant lymph nodes and skeleton are the most frequently involved sites of extrahepatic metastatic hepatocellular carcinoma. Adrenal glands, muscles, brain and peritoneum are also involved but to a lesser extent.Manjit SarmaSubramanyam PadmaParvathy PavithranVijay Harish SomasundaramPalanisamy Shanmuga SundaramSpringerOpenarticleHepatocellular carcinomaExtrahepatic metastasisFDG PET CTNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of the Egyptian National Cancer Institute, Vol 33, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hepatocellular carcinoma Extrahepatic metastasis FDG PET CT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Hepatocellular carcinoma Extrahepatic metastasis FDG PET CT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Manjit Sarma Subramanyam Padma Parvathy Pavithran Vijay Harish Somasundaram Palanisamy Shanmuga Sundaram Extrahepatic metastases of hepatocellular carcinoma on 18F FDG PET CT
description	Abstract Background To determine locations, relative frequencies, imaging features, and pattern of distribution of extrahepatic metastasis from hepatocellular carcinoma (HCC) on 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG) PET CT. Methods FDG PET CT scans of 224 consecutive patients of HCC acquired between 2010 and 2018 were reviewed. Fifty-six patients detected with extrahepatic metastasis on FDG PET CT were retrospectively analyzed. Findings were correlated with prior/follow-up imaging studies, clinical findings, FNAC, or biopsy findings whenever available. Descriptive analysis of location, relative frequencies, imaging features, and pattern of distribution of extrahepatic metastasis was done. Results Commonest were metastatic pulmonary nodules (55.3% patients), most of them being well-defined solid lesions (53.5%) with bilateral involvement in 44.6% patients and lower lobes of lungs along with other lobes being more frequently involved (41.0% patients). While in 7.14% patients lung nodules were FDG avid, 23.2% patients had both FDG avid and non-avid pulmonary nodules. Second most common were regional metastatic lymph nodes in 44.65% of patients seen at aortocaval (25%), paraaortic (23.21%), portocaval (21.4%), and left gastric nodal (17.8% of patients) stations. Twenty-five percent of patients had FDG avid lymph nodes and 5.36% patients had both FDG avid and FDG non-avid lymph nodes. Distant metastatic lymph nodes were third most common in 39.2% of patients seen at paratracheal (2.5%), juxtaphrenic (8.9%), and mesenteric lymphnodal (7.1%) stations. Twenty-five percent of patients had FDG avid lymph nodes while 5.36% patients had both FDG avid and FDG non-avid lymph nodes. Skeletal involvement was seen in 32.1% of patients. Commonest sites are vertebrae (16.7%), pelvis (14.2%), and ribs (10.7% patients). Six out of 7 patients had unilateral adrenal gland involvement. Bilateral adrenal gland involvement was seen in 1 patient. FDG non-avid peritoneal/omental metastases was seen in 2 patients. Brain, spleen, and muscle metastatic lesions were seen in 1 patient each out of 56 patients (1.79%). Conclusions Lungs, regional and distant lymph nodes and skeleton are the most frequently involved sites of extrahepatic metastatic hepatocellular carcinoma. Adrenal glands, muscles, brain and peritoneum are also involved but to a lesser extent.
format	article
author	Manjit Sarma Subramanyam Padma Parvathy Pavithran Vijay Harish Somasundaram Palanisamy Shanmuga Sundaram
author_facet	Manjit Sarma Subramanyam Padma Parvathy Pavithran Vijay Harish Somasundaram Palanisamy Shanmuga Sundaram
author_sort	Manjit Sarma
title	Extrahepatic metastases of hepatocellular carcinoma on 18F FDG PET CT
title_short	Extrahepatic metastases of hepatocellular carcinoma on 18F FDG PET CT
title_full	Extrahepatic metastases of hepatocellular carcinoma on 18F FDG PET CT
title_fullStr	Extrahepatic metastases of hepatocellular carcinoma on 18F FDG PET CT
title_full_unstemmed	Extrahepatic metastases of hepatocellular carcinoma on 18F FDG PET CT
title_sort	extrahepatic metastases of hepatocellular carcinoma on 18f fdg pet ct
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/98fc680aa3904e8999637dd3aa454ed6
work_keys_str_mv	AT manjitsarma extrahepaticmetastasesofhepatocellularcarcinomaon18ffdgpetct AT subramanyampadma extrahepaticmetastasesofhepatocellularcarcinomaon18ffdgpetct AT parvathypavithran extrahepaticmetastasesofhepatocellularcarcinomaon18ffdgpetct AT vijayharishsomasundaram extrahepaticmetastasesofhepatocellularcarcinomaon18ffdgpetct AT palanisamyshanmugasundaram extrahepaticmetastasesofhepatocellularcarcinomaon18ffdgpetct
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Extrahepatic metastases of hepatocellular carcinoma on 18F FDG PET CT

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