Effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography

Abstract We assessed the inter-visit repeatability of 15 × 9-mm2 swept-source OCTA (SS-OCTA; PLEX Elite 9000, Carl Zeiss Meditec) metrics in 14 healthy participants. We analysed the perfusion density (PD) of large vessels, superficial capillary plexus (SCP), and deep capillary plexus (DCP) as well a...

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Autores principales:	Jimmy Hong, Mengyuan Ke, Bingyao Tan, Amanda Lau, Damon Wong, Xinwen Yao, Xinyu Liu, Leopold Schmetterer, Jacqueline Chua
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/98fe5ead206147639d059deabc812260
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spelling	oai:doaj.org-article:98fe5ead206147639d059deabc8122602021-12-02T11:57:58ZEffect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography10.1038/s41598-020-79281-32045-2322https://doaj.org/article/98fe5ead206147639d059deabc8122602020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79281-3https://doaj.org/toc/2045-2322Abstract We assessed the inter-visit repeatability of 15 × 9-mm2 swept-source OCTA (SS-OCTA; PLEX Elite 9000, Carl Zeiss Meditec) metrics in 14 healthy participants. We analysed the perfusion density (PD) of large vessels, superficial capillary plexus (SCP), and deep capillary plexus (DCP) as well as choriocapillaris flow voids in 2 different regions: the macular region and peripheral region. Also, retinal plexus metrics were processed further using different filters (Hessian, Gabor and Bayesian) while choriocapillaris flow voids were calculated with 1 and 1.25 standard deviation (SD) thresholding algorithms. We found excellent repeatability in the perfusion densities of large vessels (ICC > 0.96). Perfusion densities varied with different filters in the macular region (SCP: 24.12–38.57% and DCP: 25.16–38.50%) and peripheral (SCP: 30.52–39.84% and DCP: 34.19–41.60%) regions. The ICCs were lower in the macular region compared to the peripheral region and lower for DCP than for SCP. For choriocapillaris flow voids, the 1.25 SD threshold resulted in fewer flow voids, while a good ICC (ICC > 0.81) was achieved using either threshold settings for flow void features in both regions. Our results suggest good repeatability of widefield SS-OCTA for the measurements of retinal perfusion density and choriocapillaris flow voids, but measurements from different filters should not be interchanged.Jimmy HongMengyuan KeBingyao TanAmanda LauDamon WongXinwen YaoXinyu LiuLeopold SchmettererJacqueline ChuaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jimmy Hong Mengyuan Ke Bingyao Tan Amanda Lau Damon Wong Xinwen Yao Xinyu Liu Leopold Schmetterer Jacqueline Chua Effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography
description	Abstract We assessed the inter-visit repeatability of 15 × 9-mm2 swept-source OCTA (SS-OCTA; PLEX Elite 9000, Carl Zeiss Meditec) metrics in 14 healthy participants. We analysed the perfusion density (PD) of large vessels, superficial capillary plexus (SCP), and deep capillary plexus (DCP) as well as choriocapillaris flow voids in 2 different regions: the macular region and peripheral region. Also, retinal plexus metrics were processed further using different filters (Hessian, Gabor and Bayesian) while choriocapillaris flow voids were calculated with 1 and 1.25 standard deviation (SD) thresholding algorithms. We found excellent repeatability in the perfusion densities of large vessels (ICC > 0.96). Perfusion densities varied with different filters in the macular region (SCP: 24.12–38.57% and DCP: 25.16–38.50%) and peripheral (SCP: 30.52–39.84% and DCP: 34.19–41.60%) regions. The ICCs were lower in the macular region compared to the peripheral region and lower for DCP than for SCP. For choriocapillaris flow voids, the 1.25 SD threshold resulted in fewer flow voids, while a good ICC (ICC > 0.81) was achieved using either threshold settings for flow void features in both regions. Our results suggest good repeatability of widefield SS-OCTA for the measurements of retinal perfusion density and choriocapillaris flow voids, but measurements from different filters should not be interchanged.
format	article
author	Jimmy Hong Mengyuan Ke Bingyao Tan Amanda Lau Damon Wong Xinwen Yao Xinyu Liu Leopold Schmetterer Jacqueline Chua
author_facet	Jimmy Hong Mengyuan Ke Bingyao Tan Amanda Lau Damon Wong Xinwen Yao Xinyu Liu Leopold Schmetterer Jacqueline Chua
author_sort	Jimmy Hong
title	Effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography
title_short	Effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography
title_full	Effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography
title_fullStr	Effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography
title_full_unstemmed	Effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography
title_sort	effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/98fe5ead206147639d059deabc812260
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Effect of vessel enhancement filters on the repeatability of measurements obtained from widefield swept-source optical coherence tomography angiography

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