Association between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis.

The objective of this systematic review was to evaluate the association between a soy-based infant diet and the onset of puberty. We included studies in which children were fed a soy-based diet, and we compared them with those who were not. The primary outcomes were the onset of puberty in girls (th...

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Autores principales:	Flávia Ramos Kazan Oliveira, Ana Flora Silva E Gustavo, Renan Braga Gonçalves, Fernanda Bolfi, Adriana Lúcia Mendes, Vania Dos Santos Nunes-Nogueira
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/99004985548043319071a189850c1e6c
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spelling	oai:doaj.org-article:99004985548043319071a189850c1e6c2021-12-02T20:11:19ZAssociation between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis.1932-620310.1371/journal.pone.0251241https://doaj.org/article/99004985548043319071a189850c1e6c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251241https://doaj.org/toc/1932-6203The objective of this systematic review was to evaluate the association between a soy-based infant diet and the onset of puberty. We included studies in which children were fed a soy-based diet, and we compared them with those who were not. The primary outcomes were the onset of puberty in girls (thelarche, pubarche, and menarche age), boys (pubarche, voice change, testicular and penis enlargement age), and both (risk of delayed and precocious puberty [PP]). Search strategies were performed in PubMed, Embase, LILACS, and CENTRAL databases. Two reviewers selected eligible studies, assessed the risk of bias, and extracted data from the included studies. The odds ratio (OR) and mean difference (MD) were calculated with a 95% confidence interval (CI) as a measure of the association between soy consumption and outcomes. We used a random-effects model to pool results across studies and the Grading of Recommendations Assessment, Development, and Evaluation to evaluate the certainty of evidence. We included eight studies in which 598 children consumed a soy-based diet but 2957 did not. The primary outcomes that could be plotted in the meta-analysis were the risk of PP and age at menarche. There was no statistical difference between groups for PP (OR: 0.51, 95% CI: 0.09 to 2.94, 3 studies, 206 participants, low certainty of evidence). No between-group difference was observed in menarche age (MD 0.14 years, 95% CI -0.16 to 0.45, 3 studies, 605 children, low certainty of evidence). One study presented this outcome in terms of median and interquartile range, and although the onset of menarche was marginally increased in girls who received a soy-based diet, the reported age was within the normal age range for menarche. We did not find any association between a soy-based infant diet and the onset of puberty in boys or girls. Trial Registration: PROSPERO registration: CRD42018088902.Flávia Ramos Kazan OliveiraAna Flora Silva E GustavoRenan Braga GonçalvesFernanda BolfiAdriana Lúcia MendesVania Dos Santos Nunes-NogueiraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251241 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Flávia Ramos Kazan Oliveira Ana Flora Silva E Gustavo Renan Braga Gonçalves Fernanda Bolfi Adriana Lúcia Mendes Vania Dos Santos Nunes-Nogueira Association between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis.
description	The objective of this systematic review was to evaluate the association between a soy-based infant diet and the onset of puberty. We included studies in which children were fed a soy-based diet, and we compared them with those who were not. The primary outcomes were the onset of puberty in girls (thelarche, pubarche, and menarche age), boys (pubarche, voice change, testicular and penis enlargement age), and both (risk of delayed and precocious puberty [PP]). Search strategies were performed in PubMed, Embase, LILACS, and CENTRAL databases. Two reviewers selected eligible studies, assessed the risk of bias, and extracted data from the included studies. The odds ratio (OR) and mean difference (MD) were calculated with a 95% confidence interval (CI) as a measure of the association between soy consumption and outcomes. We used a random-effects model to pool results across studies and the Grading of Recommendations Assessment, Development, and Evaluation to evaluate the certainty of evidence. We included eight studies in which 598 children consumed a soy-based diet but 2957 did not. The primary outcomes that could be plotted in the meta-analysis were the risk of PP and age at menarche. There was no statistical difference between groups for PP (OR: 0.51, 95% CI: 0.09 to 2.94, 3 studies, 206 participants, low certainty of evidence). No between-group difference was observed in menarche age (MD 0.14 years, 95% CI -0.16 to 0.45, 3 studies, 605 children, low certainty of evidence). One study presented this outcome in terms of median and interquartile range, and although the onset of menarche was marginally increased in girls who received a soy-based diet, the reported age was within the normal age range for menarche. We did not find any association between a soy-based infant diet and the onset of puberty in boys or girls. Trial Registration: PROSPERO registration: CRD42018088902.
format	article
author	Flávia Ramos Kazan Oliveira Ana Flora Silva E Gustavo Renan Braga Gonçalves Fernanda Bolfi Adriana Lúcia Mendes Vania Dos Santos Nunes-Nogueira
author_facet	Flávia Ramos Kazan Oliveira Ana Flora Silva E Gustavo Renan Braga Gonçalves Fernanda Bolfi Adriana Lúcia Mendes Vania Dos Santos Nunes-Nogueira
author_sort	Flávia Ramos Kazan Oliveira
title	Association between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis.
title_short	Association between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis.
title_full	Association between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis.
title_fullStr	Association between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis.
title_full_unstemmed	Association between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis.
title_sort	association between a soy-based infant diet and the onset of puberty: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/99004985548043319071a189850c1e6c
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Association between a soy-based infant diet and the onset of puberty: A systematic review and meta-analysis.

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