Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells

Zhihui Wang,* Yongfeng Tian,* Hua Zhang, Yanmei Qin, Dong Li, Li Gan, Fanhong Wu Department of Pharmaceutical Engineering, School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, People’s Republic of China *These authors contributed equally...

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Autores principales:	Wang ZH, Tian YF, Zhang H, Qin YM, Li D, Gan L, Wu FH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	mesoporous silica nanoparticles hyaluronic acid pH-sensitive lipid membrane CD44 receptor HeLa cells Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/99011b6b2eb8498bb2527a611b74da56
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spelling	oai:doaj.org-article:99011b6b2eb8498bb2527a611b74da562021-12-02T02:43:42ZUsing hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells1178-2013https://doaj.org/article/99011b6b2eb8498bb2527a611b74da562016-12-01T00:00:00Zhttps://www.dovepress.com/using-hyaluronic-acid-functionalized-ph-stimuli-responsive-mesoporous--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zhihui Wang,* Yongfeng Tian,* Hua Zhang, Yanmei Qin, Dong Li, Li Gan, Fanhong Wu Department of Pharmaceutical Engineering, School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: In this study, novel hyaluronic acid-pH stimuli-responsive lipid membrane mesoporous silica nanoparticles (HA-PL-MSNs) were designed and assembled, with the chemotherapeutic agent doxorubicin (DOX) as the model drug. HA-PL-MSNs exhibited a well-defined mesostructure covered by lipid bilayer and particle size of ~150 nm. The drug loading capacity was up to ~18.2%. DOX release could be effectively retained by the lipid bilayer in pH 7.4 buffer and exhibited a pH-triggered burst release in the acidic condition. Confocal laser scanning microscopy and fluorescence-activated cell sorting showed that HA-PL-MSNs exhibited higher cellular uptake efficiency via CD44 receptor-mediated endocytosis compared with PL-MSNs in HeLa cells. In vitro cytotoxicity studies demonstrated that HA-PL-MSNs could effectively enhance the targeted delivery of DOX and restrain the growth of HeLa cells. This might provide a promising alternative for the development of a targeted anticancer drug delivery system. Keywords: mesoporous silica nanoparticles, hyaluronic acid, pH-sensitive lipid membrane, CD44 receptor, HeLa cellsWang ZHTian YFZhang HQin YMLi DGan LWu FHDove Medical Pressarticlemesoporous silica nanoparticleshyaluronic acidpH-sensitive lipid membraneCD44 receptorHeLa cellsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 6485-6497 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesoporous silica nanoparticles hyaluronic acid pH-sensitive lipid membrane CD44 receptor HeLa cells Medicine (General) R5-920
spellingShingle	mesoporous silica nanoparticles hyaluronic acid pH-sensitive lipid membrane CD44 receptor HeLa cells Medicine (General) R5-920 Wang ZH Tian YF Zhang H Qin YM Li D Gan L Wu FH Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells
description	Zhihui Wang,* Yongfeng Tian,* Hua Zhang, Yanmei Qin, Dong Li, Li Gan, Fanhong Wu Department of Pharmaceutical Engineering, School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: In this study, novel hyaluronic acid-pH stimuli-responsive lipid membrane mesoporous silica nanoparticles (HA-PL-MSNs) were designed and assembled, with the chemotherapeutic agent doxorubicin (DOX) as the model drug. HA-PL-MSNs exhibited a well-defined mesostructure covered by lipid bilayer and particle size of ~150 nm. The drug loading capacity was up to ~18.2%. DOX release could be effectively retained by the lipid bilayer in pH 7.4 buffer and exhibited a pH-triggered burst release in the acidic condition. Confocal laser scanning microscopy and fluorescence-activated cell sorting showed that HA-PL-MSNs exhibited higher cellular uptake efficiency via CD44 receptor-mediated endocytosis compared with PL-MSNs in HeLa cells. In vitro cytotoxicity studies demonstrated that HA-PL-MSNs could effectively enhance the targeted delivery of DOX and restrain the growth of HeLa cells. This might provide a promising alternative for the development of a targeted anticancer drug delivery system. Keywords: mesoporous silica nanoparticles, hyaluronic acid, pH-sensitive lipid membrane, CD44 receptor, HeLa cells
format	article
author	Wang ZH Tian YF Zhang H Qin YM Li D Gan L Wu FH
author_facet	Wang ZH Tian YF Zhang H Qin YM Li D Gan L Wu FH
author_sort	Wang ZH
title	Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells
title_short	Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells
title_full	Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells
title_fullStr	Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells
title_full_unstemmed	Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells
title_sort	using hyaluronic acid-functionalized ph stimuli-responsive mesoporous silica nanoparticles for targeted delivery to cd44-overexpressing cancer cells
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/99011b6b2eb8498bb2527a611b74da56
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Using hyaluronic acid-functionalized pH stimuli-responsive mesoporous silica nanoparticles for targeted delivery to CD44-overexpressing cancer cells

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