Non-alcoholic fatty liver disease in polycystic ovary syndrome women

Abstract To evaluate risk factors leading to non-alcoholic fatty liver disease (NAFLD) occurrence in polycystic ovarian syndrome (PCOS) women. A retrospective cohort study of a total of 586 women diagnosed with PCOS aged 13–35 years at the gynecology department at a university hospital was done to e...

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Autores principales:	Young Bin Won, Seok Kyo Seo, Bo Hyon Yun, SiHyun Cho, Young Sik Choi, Byung Seok Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/990263312f9c4696aa68735891dde309
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spelling	oai:doaj.org-article:990263312f9c4696aa68735891dde3092021-12-02T13:26:32ZNon-alcoholic fatty liver disease in polycystic ovary syndrome women10.1038/s41598-021-86697-y2045-2322https://doaj.org/article/990263312f9c4696aa68735891dde3092021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86697-yhttps://doaj.org/toc/2045-2322Abstract To evaluate risk factors leading to non-alcoholic fatty liver disease (NAFLD) occurrence in polycystic ovarian syndrome (PCOS) women. A retrospective cohort study of a total of 586 women diagnosed with PCOS aged 13–35 years at the gynecology department at a university hospital was done to evaluate PCOS phenotype, metabolic syndrome (MetS) diagnosis, body composition, insulin sensitivity, sex hormones, lipid profile, liver function, and transient elastography (TE). In PCOS women with NAFLD compared to those without, MetS diagnosis (Hazard ratio [HR] 5.6, 95% Confidence interval [CI] 2.2–14.4, p < 0.01) and hyperandrogenism (HA) (HR 4.4, 95% CI 1.4–13.4, p = 0.01) were risk factors significantly associated with subsequent NAFLD occurrence, whereas 2-h insulin level in 75 g glucose tolerance test (GTT) (HR 1.2, 95% CI 0.5–2.5, p = 0.70) and body mass index (BMI) > 25 kg/m2 (HR 2.2, 95% CI 0.6–8.0, p = 0.24) was not. Among NAFLD patients who underwent TE, a higher number of MetS components indicated a worse degree of fibrosis and steatosis. MetS diagnosis and HA at PCOS diagnosis were risk factors associated with NAFLD, while 2-h insulin level in 75 g GTT and obesity were not. Although elevated aspartate aminotransferase levels were significant for NAFLD risk, liver enzyme elevations may not be present until late liver damage. Further prospective studies of PCOS women with MetS or HA are warranted to determine whether patients without liver enzyme elevations should undergo preemptive liver examinations.Young Bin WonSeok Kyo SeoBo Hyon YunSiHyun ChoYoung Sik ChoiByung Seok LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Young Bin Won Seok Kyo Seo Bo Hyon Yun SiHyun Cho Young Sik Choi Byung Seok Lee Non-alcoholic fatty liver disease in polycystic ovary syndrome women
description	Abstract To evaluate risk factors leading to non-alcoholic fatty liver disease (NAFLD) occurrence in polycystic ovarian syndrome (PCOS) women. A retrospective cohort study of a total of 586 women diagnosed with PCOS aged 13–35 years at the gynecology department at a university hospital was done to evaluate PCOS phenotype, metabolic syndrome (MetS) diagnosis, body composition, insulin sensitivity, sex hormones, lipid profile, liver function, and transient elastography (TE). In PCOS women with NAFLD compared to those without, MetS diagnosis (Hazard ratio [HR] 5.6, 95% Confidence interval [CI] 2.2–14.4, p < 0.01) and hyperandrogenism (HA) (HR 4.4, 95% CI 1.4–13.4, p = 0.01) were risk factors significantly associated with subsequent NAFLD occurrence, whereas 2-h insulin level in 75 g glucose tolerance test (GTT) (HR 1.2, 95% CI 0.5–2.5, p = 0.70) and body mass index (BMI) > 25 kg/m2 (HR 2.2, 95% CI 0.6–8.0, p = 0.24) was not. Among NAFLD patients who underwent TE, a higher number of MetS components indicated a worse degree of fibrosis and steatosis. MetS diagnosis and HA at PCOS diagnosis were risk factors associated with NAFLD, while 2-h insulin level in 75 g GTT and obesity were not. Although elevated aspartate aminotransferase levels were significant for NAFLD risk, liver enzyme elevations may not be present until late liver damage. Further prospective studies of PCOS women with MetS or HA are warranted to determine whether patients without liver enzyme elevations should undergo preemptive liver examinations.
format	article
author	Young Bin Won Seok Kyo Seo Bo Hyon Yun SiHyun Cho Young Sik Choi Byung Seok Lee
author_facet	Young Bin Won Seok Kyo Seo Bo Hyon Yun SiHyun Cho Young Sik Choi Byung Seok Lee
author_sort	Young Bin Won
title	Non-alcoholic fatty liver disease in polycystic ovary syndrome women
title_short	Non-alcoholic fatty liver disease in polycystic ovary syndrome women
title_full	Non-alcoholic fatty liver disease in polycystic ovary syndrome women
title_fullStr	Non-alcoholic fatty liver disease in polycystic ovary syndrome women
title_full_unstemmed	Non-alcoholic fatty liver disease in polycystic ovary syndrome women
title_sort	non-alcoholic fatty liver disease in polycystic ovary syndrome women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/990263312f9c4696aa68735891dde309
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Non-alcoholic fatty liver disease in polycystic ovary syndrome women

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