OUTCOMES OF ALLOGENEIC SC TRANSPLANT IN HEMATOLOGICAL MALIGNANCY PATIENTS USING BUSULFAN 3 (9.6 MG/KG) BASED CONDITIONING REGIMEN
Objective: To study the outcomes of allo-HCT in patients with hematological malignancy who received BU3 (9.6 mg/kg) based conditioning from matched related or unrelated donors. Methodology: A retrospective analysis of KFSHRC- BMT Database, we identified 65 patients who received Allo-HCT between Octo...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/990786919fe843c4b5cddd2870568c6b |
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| Sumario: | Objective: To study the outcomes of allo-HCT in patients with hematological malignancy who received BU3 (9.6 mg/kg) based conditioning from matched related or unrelated donors. Methodology: A retrospective analysis of KFSHRC- BMT Database, we identified 65 patients who received Allo-HCT between October 2005 and December 2019 at King Faisal Specialist Hospital & Research Center. The patients received SCT from full HLA matched related or unrelated donors. We excluded Mismatched MUD, Cord & Haplo-identical Stem Cell sources. Results: We identified 47 AML (72.3%), 8 MDS (12.3%), 8 Myelofibrosis (12.3%) & 2 CML (3.1%) patients. Acute GvHD grade II-IV and III-IV occurred in 29% and 14% respectively. Chronic GvHD occurred in 55% and was extensive in 24% of patients. With Median follow-up 60.5 months, 2 years and 5 years OS were 58.5 % and 44.1% respectively. The 2 years and 5 years DFS were 52.9% and 44.5% respectively. Cumulative incidence of relapse and NRM at 2- years were 29.5% and 17.4% respectively. Day +100 TRM were 10.7% Conclusion: Allogeneic SCT using BU3 based regimen appears feasible to use in patients who are not suitable for fully myeloablative (BU4) regimen. TRM, DFS & OS rate were comparable to reports from studies using BU4 based regimen, warranting prospective studies in these patients. |
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