Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction

<h4>Background</h4> Rheumatic heart disease (RHD) complicating acute rheumatic fever (ARF) remains an important health problem in developing countries. No definitive diagnostic test for ARF exists and the role of Doppler echocardiography (DEC) for long-term prognostic evaluation followin...

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Autores principales: Telêmaco Luis da Silva, Antonio Pazin-Filho, Minna M. D. Romano, Virgínia P. L. Ferriani, José A. Marin-Neto, Benedito C. Maciel, André Schmidt
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spelling oai:doaj.org-article:990dbc049b414addaca93f599a59a23a2021-11-25T06:19:46ZMitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction1932-6203https://doaj.org/article/990dbc049b414addaca93f599a59a23a2021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598055/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Rheumatic heart disease (RHD) complicating acute rheumatic fever (ARF) remains an important health problem in developing countries. No definitive diagnostic test for ARF exists and the role of Doppler echocardiography (DEC) for long-term prognostic evaluation following ARF is not well established. <h4>Objective</h4> To investigate the prognostic value of DEC in patients with ARF as a predictor of chronic valve dysfunction. <h4>Methods</h4> Prospectively enrolled patients with clinical ARF had a DEC performed soon after diagnosis and repeated at 1, 3, 6 and 12 months and thereafter at every 1–2 years. We defined chronic valve dysfunction by ≥ 3 of the following: increased valve thickening, commissure fusion, subvalvular thickening, reduced leaflet mobility, non-trivial mitral and/or aortic regurgitation. We performed univariate analysis and developed multivariate logistic regression models to identify variables that may influence evolution to RHD. p <0.05 was considered significant. <h4>Results</h4> We evaluated 70(57% men) patients, 10.8±5.6 years-old during the ARF episode and followed for 95±26 months. Chronic valve dysfunction was identified in 36(51.4%) which fulfilled criteria for RHD and 10(27.8%) of them died or underwent valve surgery. Univariate analysis showed that mitral valve thickening and presence of mitral regurgitation at baseline DEC, were associated with RHD(p<0.01). Multivariate logistic regression showed that only mitral valve thickness either as a continuous (Odds-Ratio:5.8;95%CI:1.7–19.7) or as a categorical variable (Odds-Ratio:4.04;95%CI:1.06–15.3) was an independent predictor of chronic valve dysfunction. <h4>Conclusions</h4> Mitral leaflets thickening documented at the time of diagnosis of ARF is a consistent prognostic marker for the subsequent evolution to RHD.Telêmaco Luis da SilvaAntonio Pazin-FilhoMinna M. D. RomanoVirgínia P. L. FerrianiJosé A. Marin-NetoBenedito C. MacielAndré SchmidtPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Telêmaco Luis da Silva
Antonio Pazin-Filho
Minna M. D. Romano
Virgínia P. L. Ferriani
José A. Marin-Neto
Benedito C. Maciel
André Schmidt
Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction
description <h4>Background</h4> Rheumatic heart disease (RHD) complicating acute rheumatic fever (ARF) remains an important health problem in developing countries. No definitive diagnostic test for ARF exists and the role of Doppler echocardiography (DEC) for long-term prognostic evaluation following ARF is not well established. <h4>Objective</h4> To investigate the prognostic value of DEC in patients with ARF as a predictor of chronic valve dysfunction. <h4>Methods</h4> Prospectively enrolled patients with clinical ARF had a DEC performed soon after diagnosis and repeated at 1, 3, 6 and 12 months and thereafter at every 1–2 years. We defined chronic valve dysfunction by ≥ 3 of the following: increased valve thickening, commissure fusion, subvalvular thickening, reduced leaflet mobility, non-trivial mitral and/or aortic regurgitation. We performed univariate analysis and developed multivariate logistic regression models to identify variables that may influence evolution to RHD. p <0.05 was considered significant. <h4>Results</h4> We evaluated 70(57% men) patients, 10.8±5.6 years-old during the ARF episode and followed for 95±26 months. Chronic valve dysfunction was identified in 36(51.4%) which fulfilled criteria for RHD and 10(27.8%) of them died or underwent valve surgery. Univariate analysis showed that mitral valve thickening and presence of mitral regurgitation at baseline DEC, were associated with RHD(p<0.01). Multivariate logistic regression showed that only mitral valve thickness either as a continuous (Odds-Ratio:5.8;95%CI:1.7–19.7) or as a categorical variable (Odds-Ratio:4.04;95%CI:1.06–15.3) was an independent predictor of chronic valve dysfunction. <h4>Conclusions</h4> Mitral leaflets thickening documented at the time of diagnosis of ARF is a consistent prognostic marker for the subsequent evolution to RHD.
format article
author Telêmaco Luis da Silva
Antonio Pazin-Filho
Minna M. D. Romano
Virgínia P. L. Ferriani
José A. Marin-Neto
Benedito C. Maciel
André Schmidt
author_facet Telêmaco Luis da Silva
Antonio Pazin-Filho
Minna M. D. Romano
Virgínia P. L. Ferriani
José A. Marin-Neto
Benedito C. Maciel
André Schmidt
author_sort Telêmaco Luis da Silva
title Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction
title_short Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction
title_full Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction
title_fullStr Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction
title_full_unstemmed Mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction
title_sort mitral valve thickening in acute rheumatic fever as a predictor of late valvar dysfunction
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/990dbc049b414addaca93f599a59a23a
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