Radiosurgical treatment of residual and recurrent pituitary adenomas

Objective ‒ the treatment result estimation of subtotally removed and recurrent pituitary adenomas using different algorithms of radiotherapy and radiosurgery. Materials and methods. The retrospective analysis of 21 cases of pituitary adenomas was performed. There were 11 women and 10 men included....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	O.M. Voznyak, O.S. Silaieva, M.Ye. Polishchuk, N.O. Hryniv
Formato:	article
Lenguaje:	EN RU UK
Publicado:	NAMS of Ukraine, State Organization "Scientific-Practical Center of Endovascular Neuroradiology, Non-Governmental Organization “All Ukrainian Association of Endovascular Neuroradiology, Shupyk National Healthcare University of Ukraine 2021
Materias:	key words: pituitary adenoma; stereotactic radiosurgery; fractional radiotherapy; prolactin; growth hormone, adrenocorticotropic hormone. Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/990dbd48a1874a8c9ad480940d1269fc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:990dbd48a1874a8c9ad480940d1269fc
record_format	dspace
spelling	oai:doaj.org-article:990dbd48a1874a8c9ad480940d1269fc2021-11-21T17:02:38ZRadiosurgical treatment of residual and recurrent pituitary adenomas2786-48552786-486310.26683/2786-4855-2021-1(35)-26-32https://doaj.org/article/990dbd48a1874a8c9ad480940d1269fc2021-06-01T00:00:00Zhttps://enj.org.ua/index.php/journal/article/view/171https://doaj.org/toc/2786-4855https://doaj.org/toc/2786-4863Objective ‒ the treatment result estimation of subtotally removed and recurrent pituitary adenomas using different algorithms of radiotherapy and radiosurgery. Materials and methods. The retrospective analysis of 21 cases of pituitary adenomas was performed. There were 11 women and 10 men included. The average age was 45 (from 18 to 72) years. All patients had relapse or residual tumor after incomplete surgical removal. The method of irradiation was chosen by a radiologist. Tumor size control was assessed by an independent radiologist in 3 months and 1 year after treatment. Endocrine function was estimated by an independent endocrinologist in 3 months and 1 year after treatment. Results. Following transsphenoidal removal ‒ 13 patients (4 were operated twice), 5 after cranial surgery and 3 were operated sequentially transnasally and transcranially. Irradiation of 14 cases of residual tumor was performed no later than 6 months after surgery. The mean term of treatment start of recurrent adenomas was 12 months (8‒17) after surgery. VARIAN Novalis was applied in 16 cases, VARIAN Clinac iX in 4 cases and VARIAN TrueBeam STx was used once. Single and total radiation doses were determined individually. None of patients had visual impairment after treatment. The hypopituitarism deterioration was not noted as well. Conclusions. Hypofractionated stereotactic radiosurgery allows to bring a high dose of radiation to the pituitary adenomas, minimizing damage to the visual pathways, the pituitary gland and infundibulum. As the sequence, it reduces the toxicity of the technique. The application of modern radiation technologies minimize the irradiation of healthy surrounding tissues and reduce the negative effects of treatment.O.M. VoznyakO.S. SilaievaM.Ye. PolishchukN.O. HrynivNAMS of Ukraine, State Organization "Scientific-Practical Center of Endovascular Neuroradiology, Non-Governmental Organization “All Ukrainian Association of Endovascular Neuroradiology, Shupyk National Healthcare University of Ukrainearticlekey words: pituitary adenoma; stereotactic radiosurgery; fractional radiotherapy; prolactin; growth hormone, adrenocorticotropic hormone.Medical physics. Medical radiology. Nuclear medicineR895-920ENRUUKУкраїнська Інтервенційна Нейрорадіологія та Хірургія, Vol 35, Iss 1, Pp 26-32 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU UK
topic	key words: pituitary adenoma; stereotactic radiosurgery; fractional radiotherapy; prolactin; growth hormone, adrenocorticotropic hormone. Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	key words: pituitary adenoma; stereotactic radiosurgery; fractional radiotherapy; prolactin; growth hormone, adrenocorticotropic hormone. Medical physics. Medical radiology. Nuclear medicine R895-920 O.M. Voznyak O.S. Silaieva M.Ye. Polishchuk N.O. Hryniv Radiosurgical treatment of residual and recurrent pituitary adenomas
description	Objective ‒ the treatment result estimation of subtotally removed and recurrent pituitary adenomas using different algorithms of radiotherapy and radiosurgery. Materials and methods. The retrospective analysis of 21 cases of pituitary adenomas was performed. There were 11 women and 10 men included. The average age was 45 (from 18 to 72) years. All patients had relapse or residual tumor after incomplete surgical removal. The method of irradiation was chosen by a radiologist. Tumor size control was assessed by an independent radiologist in 3 months and 1 year after treatment. Endocrine function was estimated by an independent endocrinologist in 3 months and 1 year after treatment. Results. Following transsphenoidal removal ‒ 13 patients (4 were operated twice), 5 after cranial surgery and 3 were operated sequentially transnasally and transcranially. Irradiation of 14 cases of residual tumor was performed no later than 6 months after surgery. The mean term of treatment start of recurrent adenomas was 12 months (8‒17) after surgery. VARIAN Novalis was applied in 16 cases, VARIAN Clinac iX in 4 cases and VARIAN TrueBeam STx was used once. Single and total radiation doses were determined individually. None of patients had visual impairment after treatment. The hypopituitarism deterioration was not noted as well. Conclusions. Hypofractionated stereotactic radiosurgery allows to bring a high dose of radiation to the pituitary adenomas, minimizing damage to the visual pathways, the pituitary gland and infundibulum. As the sequence, it reduces the toxicity of the technique. The application of modern radiation technologies minimize the irradiation of healthy surrounding tissues and reduce the negative effects of treatment.
format	article
author	O.M. Voznyak O.S. Silaieva M.Ye. Polishchuk N.O. Hryniv
author_facet	O.M. Voznyak O.S. Silaieva M.Ye. Polishchuk N.O. Hryniv
author_sort	O.M. Voznyak
title	Radiosurgical treatment of residual and recurrent pituitary adenomas
title_short	Radiosurgical treatment of residual and recurrent pituitary adenomas
title_full	Radiosurgical treatment of residual and recurrent pituitary adenomas
title_fullStr	Radiosurgical treatment of residual and recurrent pituitary adenomas
title_full_unstemmed	Radiosurgical treatment of residual and recurrent pituitary adenomas
title_sort	radiosurgical treatment of residual and recurrent pituitary adenomas
publisher	NAMS of Ukraine, State Organization "Scientific-Practical Center of Endovascular Neuroradiology, Non-Governmental Organization “All Ukrainian Association of Endovascular Neuroradiology, Shupyk National Healthcare University of Ukraine
publishDate	2021
url	https://doaj.org/article/990dbd48a1874a8c9ad480940d1269fc
work_keys_str_mv	AT omvoznyak radiosurgicaltreatmentofresidualandrecurrentpituitaryadenomas AT ossilaieva radiosurgicaltreatmentofresidualandrecurrentpituitaryadenomas AT myepolishchuk radiosurgicaltreatmentofresidualandrecurrentpituitaryadenomas AT nohryniv radiosurgicaltreatmentofresidualandrecurrentpituitaryadenomas
_version_	1718418715693809664

Radiosurgical treatment of residual and recurrent pituitary adenomas

Ejemplares similares