“Polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws

Interference screws are commonly used for the treatment of ruptured ligaments. The interference screws are often constructed from polylactic acid (PLA). In this study, a melt blend of PLA, polyethylene glycol (PEG) and hydroxyapatite (HA) was investigated for use in interference screws. For this pur...

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Autores principales:	Fatemeh Nedaipour, Hamed Bagheri, Soheila Mohammadi
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	polylactic acid polyethylene glycol hydroxyapatite composites interference screws biomaterials bioresorbable Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185
Acceso en línea:	https://doaj.org/article/990e8b3f9949483eaeeba79ef7439587
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id	oai:doaj.org-article:990e8b3f9949483eaeeba79ef7439587
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spelling	oai:doaj.org-article:990e8b3f9949483eaeeba79ef74395872021-12-02T16:16:38Z“Polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws2055-033210.1080/20550324.2020.1794688https://doaj.org/article/990e8b3f9949483eaeeba79ef74395872020-07-01T00:00:00Zhttp://dx.doi.org/10.1080/20550324.2020.1794688https://doaj.org/toc/2055-0332Interference screws are commonly used for the treatment of ruptured ligaments. The interference screws are often constructed from polylactic acid (PLA). In this study, a melt blend of PLA, polyethylene glycol (PEG) and hydroxyapatite (HA) was investigated for use in interference screws. For this purpose, mechanical properties, differential scanning calorimetry (DSC), degradation rate, pH change, water contact angle, morphology, cytotoxicity, and cell adhesion on the specimens were investigated. According to the tensile test results, by mixing various levels of PLA, PEG, and HA, mechanical properties of the resulting composite can be kept constant or even improved in comparison with pure PLA. DSC proved the miscibility of components and provided a softer product after adding PEG to the mixture. The weight loss of samples was investigated over a period of 7 months and the results indicated an increase in the degradation rate by increasing PEG level. pH changes were also investigated indicating no significant change in pH. The contact angle test showed an increase in the hydrophilic nature of all specimens with increasing PEG and HA levels. Surface morphology was studied by scanning electron microscope (SEM) and the results showed an increase in toughness with increasing PEG level. 2 µm HA particles and HA agglomeration in some areas were clearly observed in the SEM micrographs. According to the MTT test, none of the samples caused cell death, and results also showed good and spread cell adhesion to the specimens.Fatemeh NedaipourHamed BagheriSoheila MohammadiTaylor & Francis Grouparticlepolylactic acidpolyethylene glycolhydroxyapatitecompositesinterference screwsbiomaterialsbioresorbableMaterials of engineering and construction. Mechanics of materialsTA401-492Polymers and polymer manufactureTP1080-1185ENNanocomposites, Vol 6, Iss 3, Pp 99-110 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	polylactic acid polyethylene glycol hydroxyapatite composites interference screws biomaterials bioresorbable Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185
spellingShingle	polylactic acid polyethylene glycol hydroxyapatite composites interference screws biomaterials bioresorbable Materials of engineering and construction. Mechanics of materials TA401-492 Polymers and polymer manufacture TP1080-1185 Fatemeh Nedaipour Hamed Bagheri Soheila Mohammadi “Polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws
description	Interference screws are commonly used for the treatment of ruptured ligaments. The interference screws are often constructed from polylactic acid (PLA). In this study, a melt blend of PLA, polyethylene glycol (PEG) and hydroxyapatite (HA) was investigated for use in interference screws. For this purpose, mechanical properties, differential scanning calorimetry (DSC), degradation rate, pH change, water contact angle, morphology, cytotoxicity, and cell adhesion on the specimens were investigated. According to the tensile test results, by mixing various levels of PLA, PEG, and HA, mechanical properties of the resulting composite can be kept constant or even improved in comparison with pure PLA. DSC proved the miscibility of components and provided a softer product after adding PEG to the mixture. The weight loss of samples was investigated over a period of 7 months and the results indicated an increase in the degradation rate by increasing PEG level. pH changes were also investigated indicating no significant change in pH. The contact angle test showed an increase in the hydrophilic nature of all specimens with increasing PEG and HA levels. Surface morphology was studied by scanning electron microscope (SEM) and the results showed an increase in toughness with increasing PEG level. 2 µm HA particles and HA agglomeration in some areas were clearly observed in the SEM micrographs. According to the MTT test, none of the samples caused cell death, and results also showed good and spread cell adhesion to the specimens.
format	article
author	Fatemeh Nedaipour Hamed Bagheri Soheila Mohammadi
author_facet	Fatemeh Nedaipour Hamed Bagheri Soheila Mohammadi
author_sort	Fatemeh Nedaipour
title	“Polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws
title_short	“Polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws
title_full	“Polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws
title_fullStr	“Polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws
title_full_unstemmed	“Polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws
title_sort	“polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/990e8b3f9949483eaeeba79ef7439587
work_keys_str_mv	AT fatemehnedaipour polylacticacidpolyethyleneglycolhydroxyapatitecompositeanefficientcompositionforinterferencescrews AT hamedbagheri polylacticacidpolyethyleneglycolhydroxyapatitecompositeanefficientcompositionforinterferencescrews AT soheilamohammadi polylacticacidpolyethyleneglycolhydroxyapatitecompositeanefficientcompositionforinterferencescrews
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“Polylactic acid-polyethylene glycol-hydroxyapatite composite” an efficient composition for interference screws

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