Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis

Yong-Tai Zhang, Li-Na Shen, Ji-Hui Zhao, Nian-Ping FengDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of ChinaAbstract: This study aimed to improve skin permeation and deposition of psoralen by using ethosomes and to i...

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Autores principales:	Zhang YT, Shen LN, Zhao JH, Feng NP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/990f543a6cf24f7ea4cf9ddfdf02a04a
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spelling	oai:doaj.org-article:990f543a6cf24f7ea4cf9ddfdf02a04a2021-12-02T04:20:56ZEvaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis1178-2013https://doaj.org/article/990f543a6cf24f7ea4cf9ddfdf02a04a2014-01-01T00:00:00Zhttp://www.dovepress.com/evaluation-of-psoralen-ethosomes-for-topical-delivery-in-rats-by-using-a15612https://doaj.org/toc/1178-2013 Yong-Tai Zhang, Li-Na Shen, Ji-Hui Zhao, Nian-Ping FengDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of ChinaAbstract: This study aimed to improve skin permeation and deposition of psoralen by using ethosomes and to investigate real-time drug release in the deep skin in rats. We used a uniform design method to evaluate the effects of different ethosome formulations on entrapment efficiency and drug skin deposition. Using in vitro and in vivo methods, we investigated skin penetration and release from psoralen-loaded ethosomes in comparison with an ethanol tincture. In in vitro studies, the use of ethosomes was associated with a 6.56-fold greater skin deposition of psoralen than that achieved with the use of the tincture. In vivo skin microdialysis showed that the peak concentration and area under the curve of psoralen from ethosomes were approximately 3.37 and 2.34 times higher, respectively, than those of psoralen from the tincture. Moreover, it revealed that the percutaneous permeability of ethosomes was greater when applied to the abdomen than when applied to the chest or scapulas. Enhanced permeation and skin deposition of psoralen delivered by ethosomes may help reduce toxicity and improve the efficacy of long-term psoralen treatment.Keywords: absorption enhancer, formulation vehicle, nanocarriers, nanoparticles, transdermalZhang YTShen LNZhao JHFeng NPDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 669-678 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhang YT Shen LN Zhao JH Feng NP Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
description	Yong-Tai Zhang, Li-Na Shen, Ji-Hui Zhao, Nian-Ping FengDepartment of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of ChinaAbstract: This study aimed to improve skin permeation and deposition of psoralen by using ethosomes and to investigate real-time drug release in the deep skin in rats. We used a uniform design method to evaluate the effects of different ethosome formulations on entrapment efficiency and drug skin deposition. Using in vitro and in vivo methods, we investigated skin penetration and release from psoralen-loaded ethosomes in comparison with an ethanol tincture. In in vitro studies, the use of ethosomes was associated with a 6.56-fold greater skin deposition of psoralen than that achieved with the use of the tincture. In vivo skin microdialysis showed that the peak concentration and area under the curve of psoralen from ethosomes were approximately 3.37 and 2.34 times higher, respectively, than those of psoralen from the tincture. Moreover, it revealed that the percutaneous permeability of ethosomes was greater when applied to the abdomen than when applied to the chest or scapulas. Enhanced permeation and skin deposition of psoralen delivered by ethosomes may help reduce toxicity and improve the efficacy of long-term psoralen treatment.Keywords: absorption enhancer, formulation vehicle, nanocarriers, nanoparticles, transdermal
format	article
author	Zhang YT Shen LN Zhao JH Feng NP
author_facet	Zhang YT Shen LN Zhao JH Feng NP
author_sort	Zhang YT
title	Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
title_short	Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
title_full	Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
title_fullStr	Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
title_full_unstemmed	Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
title_sort	evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/990f543a6cf24f7ea4cf9ddfdf02a04a
work_keys_str_mv	AT zhangyt evaluationofpsoralenethosomesfortopicaldeliveryinratsbyusinginvivomicrodialysis AT shenln evaluationofpsoralenethosomesfortopicaldeliveryinratsbyusinginvivomicrodialysis AT zhaojh evaluationofpsoralenethosomesfortopicaldeliveryinratsbyusinginvivomicrodialysis AT fengnp evaluationofpsoralenethosomesfortopicaldeliveryinratsbyusinginvivomicrodialysis
_version_	1718401323787878400

Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis

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