Tracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial

Abstract Background Occipital transcranial direct current stimulation (tDCS) is an effective and safe treatment for migraine attack prevention. Structural brain alterations have been found in migraineurs in regions related to pain modulation and perception, including occipital areas. However, whethe...

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Autores principales:	Simon Schading, Heiko Pohl, Andreas Gantenbein, Roger Luechinger, Peter Sandor, Franz Riederer, Patrick Freund, Lars Michels
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Transcranial direct current stimulation Migraine Structural alterations Voxel-based morphometry Brain plasticity Structural MRI Medicine R
Acceso en línea:	https://doaj.org/article/99105e56547b4d838f5b77b079a7750b
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spelling	oai:doaj.org-article:99105e56547b4d838f5b77b079a7750b2021-11-21T12:39:31ZTracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial10.1186/s10194-021-01347-y1129-23691129-2377https://doaj.org/article/99105e56547b4d838f5b77b079a7750b2021-11-01T00:00:00Zhttps://doi.org/10.1186/s10194-021-01347-yhttps://doaj.org/toc/1129-2369https://doaj.org/toc/1129-2377Abstract Background Occipital transcranial direct current stimulation (tDCS) is an effective and safe treatment for migraine attack prevention. Structural brain alterations have been found in migraineurs in regions related to pain modulation and perception, including occipital areas. However, whether these structural alterations can be dynamically modulated through tDCS treatment is understudied. Objective To track longitudinally grey matter volume changes in occipital areas in episodic migraineurs during and up to five months after occipital tDCS treatment in a single-blind, and sham-controlled study. Methods 24 episodic migraineurs were randomized to either receive verum or sham occipital tDCS treatment for 28 days. To investigate dynamic grey matter volume changes patients underwent structural MRI at baseline (prior to treatment), 1.5 months and 5.5 months (after completion of treatment). 31 healthy controls were scanned with the same MRI protocol. Morphometry measures assessed rate of changes over time and between groups by means of tensor-based morphometry. Results Before treatment, migraineurs reported 5.6 monthly migraine days on average. A cross-sectional analysis revealed grey matter volume increases in the left lingual gyrus in migraineurs compared to controls. Four weeks of tDCS application led to a reduction of 1.9 migraine days/month and was paralleled by grey matter volume decreases in the left lingual gyrus in the treatment group; its extent overlapping with that seen at baseline. Conclusion This study shows that migraineurs have increased grey matter volume in the lingual gyrus, which can be modified by tDCS. Tracking structural plasticity in migraineurs provides a potential neuroimaging biomarker for treatment monitoring. Trial registration ClinicalTrials.gov , NCT03237754 . Registered 03 August 2017 – retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03237754 .Simon SchadingHeiko PohlAndreas GantenbeinRoger LuechingerPeter SandorFranz RiedererPatrick FreundLars MichelsBMCarticleTranscranial direct current stimulationMigraineStructural alterationsVoxel-based morphometryBrain plasticityStructural MRIMedicineRENThe Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Transcranial direct current stimulation Migraine Structural alterations Voxel-based morphometry Brain plasticity Structural MRI Medicine R
spellingShingle	Transcranial direct current stimulation Migraine Structural alterations Voxel-based morphometry Brain plasticity Structural MRI Medicine R Simon Schading Heiko Pohl Andreas Gantenbein Roger Luechinger Peter Sandor Franz Riederer Patrick Freund Lars Michels Tracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial
description	Abstract Background Occipital transcranial direct current stimulation (tDCS) is an effective and safe treatment for migraine attack prevention. Structural brain alterations have been found in migraineurs in regions related to pain modulation and perception, including occipital areas. However, whether these structural alterations can be dynamically modulated through tDCS treatment is understudied. Objective To track longitudinally grey matter volume changes in occipital areas in episodic migraineurs during and up to five months after occipital tDCS treatment in a single-blind, and sham-controlled study. Methods 24 episodic migraineurs were randomized to either receive verum or sham occipital tDCS treatment for 28 days. To investigate dynamic grey matter volume changes patients underwent structural MRI at baseline (prior to treatment), 1.5 months and 5.5 months (after completion of treatment). 31 healthy controls were scanned with the same MRI protocol. Morphometry measures assessed rate of changes over time and between groups by means of tensor-based morphometry. Results Before treatment, migraineurs reported 5.6 monthly migraine days on average. A cross-sectional analysis revealed grey matter volume increases in the left lingual gyrus in migraineurs compared to controls. Four weeks of tDCS application led to a reduction of 1.9 migraine days/month and was paralleled by grey matter volume decreases in the left lingual gyrus in the treatment group; its extent overlapping with that seen at baseline. Conclusion This study shows that migraineurs have increased grey matter volume in the lingual gyrus, which can be modified by tDCS. Tracking structural plasticity in migraineurs provides a potential neuroimaging biomarker for treatment monitoring. Trial registration ClinicalTrials.gov , NCT03237754 . Registered 03 August 2017 – retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03237754 .
format	article
author	Simon Schading Heiko Pohl Andreas Gantenbein Roger Luechinger Peter Sandor Franz Riederer Patrick Freund Lars Michels
author_facet	Simon Schading Heiko Pohl Andreas Gantenbein Roger Luechinger Peter Sandor Franz Riederer Patrick Freund Lars Michels
author_sort	Simon Schading
title	Tracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial
title_short	Tracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial
title_full	Tracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial
title_fullStr	Tracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial
title_full_unstemmed	Tracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial
title_sort	tracking tdcs induced grey matter changes in episodic migraine: a randomized controlled trial
publisher	BMC
publishDate	2021
url	https://doaj.org/article/99105e56547b4d838f5b77b079a7750b
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Tracking tDCS induced grey matter changes in episodic migraine: a randomized controlled trial

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