Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond

Sphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In th...

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Autores principales:	Shuo-Qi Zhang, Jun Xiao, Man Chen, Luo-Qi Zhou, Ke Shang, Chuan Qin, Dai-Shi Tian
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sphingosine-1-phosphate ischemic stroke fingolimod neuroprotective agent translational research Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/9910cb777bb346ada2f1b6f23b2b6835
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spelling	oai:doaj.org-article:9910cb777bb346ada2f1b6f23b2b68352021-12-01T16:02:40ZSphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond1662-510210.3389/fncel.2021.781098https://doaj.org/article/9910cb777bb346ada2f1b6f23b2b68352021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncel.2021.781098/fullhttps://doaj.org/toc/1662-5102Sphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In this article, we will review the current knowledge of the role of S1P signaling in brain ischemia from the aspects of inflammation and immune interventions, sustaining endothelial functions, regulation of blood-brain barrier integrity, and functional recovery. We will then discuss the current and future therapeutic perspectives of targeting S1P for the treatment of ischemic stroke. Mechanism studies would help to bridge the gap between preclinical studies and clinical practice. Future success of bench-to-bedside translation shall be based on in depth understanding of S1P signaling during stroke and on the ability to have a fine temporal and spatial regulation of the signal pathway.Shuo-Qi ZhangShuo-Qi ZhangJun XiaoMan ChenLuo-Qi ZhouKe ShangChuan QinDai-Shi TianFrontiers Media S.A.articlesphingosine-1-phosphateischemic strokefingolimodneuroprotective agenttranslational researchNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Cellular Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sphingosine-1-phosphate ischemic stroke fingolimod neuroprotective agent translational research Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	sphingosine-1-phosphate ischemic stroke fingolimod neuroprotective agent translational research Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Shuo-Qi Zhang Shuo-Qi Zhang Jun Xiao Man Chen Luo-Qi Zhou Ke Shang Chuan Qin Dai-Shi Tian Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
description	Sphingosine-1-phosphate (S1P) signaling is being increasingly recognized as a strong modulator of immune cell migration and endothelial function. Fingolimod and other S1P modulators in ischemic stroke treatment have shown promise in emerging experimental models and small-scale clinical trials. In this article, we will review the current knowledge of the role of S1P signaling in brain ischemia from the aspects of inflammation and immune interventions, sustaining endothelial functions, regulation of blood-brain barrier integrity, and functional recovery. We will then discuss the current and future therapeutic perspectives of targeting S1P for the treatment of ischemic stroke. Mechanism studies would help to bridge the gap between preclinical studies and clinical practice. Future success of bench-to-bedside translation shall be based on in depth understanding of S1P signaling during stroke and on the ability to have a fine temporal and spatial regulation of the signal pathway.
format	article
author	Shuo-Qi Zhang Shuo-Qi Zhang Jun Xiao Man Chen Luo-Qi Zhou Ke Shang Chuan Qin Dai-Shi Tian
author_facet	Shuo-Qi Zhang Shuo-Qi Zhang Jun Xiao Man Chen Luo-Qi Zhou Ke Shang Chuan Qin Dai-Shi Tian
author_sort	Shuo-Qi Zhang
title	Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
title_short	Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
title_full	Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
title_fullStr	Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
title_full_unstemmed	Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond
title_sort	sphingosine-1-phosphate signaling in ischemic stroke: from bench to bedside and beyond
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/9910cb777bb346ada2f1b6f23b2b6835
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Sphingosine-1-Phosphate Signaling in Ischemic Stroke: From Bench to Bedside and Beyond

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