Daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition

Abstract The importance of sun exposure on human health is well recognized, and a recent trend in the avoidance of sun exposure has led to the risk of missing the beneficial effects such as vitamin D3 biogenesis. Vitamin D3 insufficiency is one of the risk factors for the development of food allergi...

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Autores principales:	Po-Jung Chen, Toshiaki Nakano, Chia-Yun Lai, Kuei-Chen Chang, Chao-Long Chen, Shigeru Goto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/9911b503c5094fe0b3926e8d90dc10a7
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spelling	oai:doaj.org-article:9911b503c5094fe0b3926e8d90dc10a72021-12-02T14:49:36ZDaily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition10.1038/s41522-021-00213-82055-5008https://doaj.org/article/9911b503c5094fe0b3926e8d90dc10a72021-05-01T00:00:00Zhttps://doi.org/10.1038/s41522-021-00213-8https://doaj.org/toc/2055-5008Abstract The importance of sun exposure on human health is well recognized, and a recent trend in the avoidance of sun exposure has led to the risk of missing the beneficial effects such as vitamin D3 biogenesis. Vitamin D3 insufficiency is one of the risk factors for the development of food allergies (FAs), and vitamin D3 status controls gut homeostasis by modulating the microbiota. This study aimed to explore the impact of daily full spectrum light exposure (phototherapy) on the pathogenesis of FAs. Phototherapy ameliorated allergic diarrhea and improved FA-associated vitamin D3 insufficiency and dysbiosis. Fecal microbiota transplantation (FMT) of FA donor feces induced allergic diarrhea with OVA-specific IgE elevation in naïve mice. In contrast, FMT of naïve donor feces ameliorated allergic diarrhea in established FA mice, suggesting the involvement of the microbiota composition in FA. Phototherapy is an alternative approach for the prevention of FA-like allergic diarrhea through the modulation of vitamin D3 status and microbiota composition.Po-Jung ChenToshiaki NakanoChia-Yun LaiKuei-Chen ChangChao-Long ChenShigeru GotoNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Po-Jung Chen Toshiaki Nakano Chia-Yun Lai Kuei-Chen Chang Chao-Long Chen Shigeru Goto Daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition
description	Abstract The importance of sun exposure on human health is well recognized, and a recent trend in the avoidance of sun exposure has led to the risk of missing the beneficial effects such as vitamin D3 biogenesis. Vitamin D3 insufficiency is one of the risk factors for the development of food allergies (FAs), and vitamin D3 status controls gut homeostasis by modulating the microbiota. This study aimed to explore the impact of daily full spectrum light exposure (phototherapy) on the pathogenesis of FAs. Phototherapy ameliorated allergic diarrhea and improved FA-associated vitamin D3 insufficiency and dysbiosis. Fecal microbiota transplantation (FMT) of FA donor feces induced allergic diarrhea with OVA-specific IgE elevation in naïve mice. In contrast, FMT of naïve donor feces ameliorated allergic diarrhea in established FA mice, suggesting the involvement of the microbiota composition in FA. Phototherapy is an alternative approach for the prevention of FA-like allergic diarrhea through the modulation of vitamin D3 status and microbiota composition.
format	article
author	Po-Jung Chen Toshiaki Nakano Chia-Yun Lai Kuei-Chen Chang Chao-Long Chen Shigeru Goto
author_facet	Po-Jung Chen Toshiaki Nakano Chia-Yun Lai Kuei-Chen Chang Chao-Long Chen Shigeru Goto
author_sort	Po-Jung Chen
title	Daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition
title_short	Daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition
title_full	Daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition
title_fullStr	Daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition
title_full_unstemmed	Daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition
title_sort	daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin d3 and microbiota composition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9911b503c5094fe0b3926e8d90dc10a7
work_keys_str_mv	AT pojungchen dailyfullspectrumlightexposurepreventsfoodallergylikeallergicdiarrheabymodulatingvitamind3andmicrobiotacomposition AT toshiakinakano dailyfullspectrumlightexposurepreventsfoodallergylikeallergicdiarrheabymodulatingvitamind3andmicrobiotacomposition AT chiayunlai dailyfullspectrumlightexposurepreventsfoodallergylikeallergicdiarrheabymodulatingvitamind3andmicrobiotacomposition AT kueichenchang dailyfullspectrumlightexposurepreventsfoodallergylikeallergicdiarrheabymodulatingvitamind3andmicrobiotacomposition AT chaolongchen dailyfullspectrumlightexposurepreventsfoodallergylikeallergicdiarrheabymodulatingvitamind3andmicrobiotacomposition AT shigerugoto dailyfullspectrumlightexposurepreventsfoodallergylikeallergicdiarrheabymodulatingvitamind3andmicrobiotacomposition
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Daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition

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