Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates

Copper-dependent lytic polysaccharide monooxygenases (LPMOs) oxidatively cleave polysaccharides. Here the authors present a structure-function characterization of fungal LPMOs, showing that a particular LPMO cleaves xylan using a mechanism that involves an alternative copper coordination geometry.

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Autores principales:	T. J. Simmons, K. E. H. Frandsen, L. Ciano, T. Tryfona, N. Lenfant, J. C. Poulsen, L. F. L. Wilson, T. Tandrup, M. Tovborg, K. Schnorr, K. S. Johansen, B. Henrissat, P. H. Walton, L Lo Leggio, P. Dupree
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9912392e58d74f6b9220b56f49787859
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spelling	oai:doaj.org-article:9912392e58d74f6b9220b56f497878592021-12-02T14:42:09ZStructural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates10.1038/s41467-017-01247-32041-1723https://doaj.org/article/9912392e58d74f6b9220b56f497878592017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01247-3https://doaj.org/toc/2041-1723Copper-dependent lytic polysaccharide monooxygenases (LPMOs) oxidatively cleave polysaccharides. Here the authors present a structure-function characterization of fungal LPMOs, showing that a particular LPMO cleaves xylan using a mechanism that involves an alternative copper coordination geometry.T. J. SimmonsK. E. H. FrandsenL. CianoT. TryfonaN. LenfantJ. C. PoulsenL. F. L. WilsonT. TandrupM. TovborgK. SchnorrK. S. JohansenB. HenrissatP. H. WaltonL Lo LeggioP. DupreeNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q T. J. Simmons K. E. H. Frandsen L. Ciano T. Tryfona N. Lenfant J. C. Poulsen L. F. L. Wilson T. Tandrup M. Tovborg K. Schnorr K. S. Johansen B. Henrissat P. H. Walton L Lo Leggio P. Dupree Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates
description	Copper-dependent lytic polysaccharide monooxygenases (LPMOs) oxidatively cleave polysaccharides. Here the authors present a structure-function characterization of fungal LPMOs, showing that a particular LPMO cleaves xylan using a mechanism that involves an alternative copper coordination geometry.
format	article
author	T. J. Simmons K. E. H. Frandsen L. Ciano T. Tryfona N. Lenfant J. C. Poulsen L. F. L. Wilson T. Tandrup M. Tovborg K. Schnorr K. S. Johansen B. Henrissat P. H. Walton L Lo Leggio P. Dupree
author_facet	T. J. Simmons K. E. H. Frandsen L. Ciano T. Tryfona N. Lenfant J. C. Poulsen L. F. L. Wilson T. Tandrup M. Tovborg K. Schnorr K. S. Johansen B. Henrissat P. H. Walton L Lo Leggio P. Dupree
author_sort	T. J. Simmons
title	Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates
title_short	Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates
title_full	Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates
title_fullStr	Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates
title_full_unstemmed	Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates
title_sort	structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9912392e58d74f6b9220b56f49787859
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Structural and electronic determinants of lytic polysaccharide monooxygenase reactivity on polysaccharide substrates

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