Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?

Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Material...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rocio Porcel-Chacón, Cristina Antúnez-Fernández, Maria Mora Loro, Ana-Belen Ariza-Jimenez, Leopoldo Tapia Ceballos, Jose Manuel Jimenez Hinojosa, Juan Pedro Lopez-Siguero, Isabel Leiva Gea
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	type 1 diabetes mellitus pediatric diabetes continuous glucose monitoring time in 28 range HbA1c capillary blood glucose test Medicine R
Acceso en línea:	https://doaj.org/article/99165e44ffba4a0bbba31374711f9c16
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:99165e44ffba4a0bbba31374711f9c16
record_format	dspace
spelling	oai:doaj.org-article:99165e44ffba4a0bbba31374711f9c162021-11-11T17:33:17ZGood Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?10.3390/jcm102149132077-0383https://doaj.org/article/99165e44ffba4a0bbba31374711f9c162021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4913https://doaj.org/toc/2077-0383Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Materials and methods: A cohort prospective study with 191 pediatric patients with T1D was conducted. Time in range (TIR), time below range (TBR), coefficient of variation (CV), number of capillary blood glucose tests, and HbA1c before sensor insertion and at one year of use were collected. Results: Patients were classified into five groups according to HbA1c at one year of using CGM. They performed fewer capillary blood glucose test at one year using CGM (−6 +/− 2, <i>p</i> < 0.0001). We found statistically significant differences in TIR between categories. Although groups with HbA1c < 6.5% and HbA1c 6.5–7% had the highest TIR (62.214 and 50.462%), their values were highly below optimal control according to CGM consensus. Groups with TBR < 5% were those with HbA1c between 6.5% and 8%. Conclusions: In our study, groups classified as well-controlled by guidelines were not consistent with good control according to the CGM consensus criteria. HbA1c should not be considered as the only parameter for metabolic control. CGM parameters allow individualized targets.Rocio Porcel-ChacónCristina Antúnez-FernándezMaria Mora LoroAna-Belen Ariza-JimenezLeopoldo Tapia CeballosJose Manuel Jimenez HinojosaJuan Pedro Lopez-SigueroIsabel Leiva GeaMDPI AGarticletype 1 diabetes mellituspediatric diabetescontinuous glucose monitoringtime in 28 rangeHbA1ccapillary blood glucose testMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4913, p 4913 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 1 diabetes mellitus pediatric diabetes continuous glucose monitoring time in 28 range HbA1c capillary blood glucose test Medicine R
spellingShingle	type 1 diabetes mellitus pediatric diabetes continuous glucose monitoring time in 28 range HbA1c capillary blood glucose test Medicine R Rocio Porcel-Chacón Cristina Antúnez-Fernández Maria Mora Loro Ana-Belen Ariza-Jimenez Leopoldo Tapia Ceballos Jose Manuel Jimenez Hinojosa Juan Pedro Lopez-Siguero Isabel Leiva Gea Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
description	Background: Good metabolic control of Type 1 diabetes (T1D) leads to a reduction in complications. The only validated parameter for establishing the degree of control is glycated hemoglobin (HbA1c). We examined the relationship between HbA1c and a continuous glucose monitoring (CGM) system. Materials and methods: A cohort prospective study with 191 pediatric patients with T1D was conducted. Time in range (TIR), time below range (TBR), coefficient of variation (CV), number of capillary blood glucose tests, and HbA1c before sensor insertion and at one year of use were collected. Results: Patients were classified into five groups according to HbA1c at one year of using CGM. They performed fewer capillary blood glucose test at one year using CGM (−6 +/− 2, <i>p</i> < 0.0001). We found statistically significant differences in TIR between categories. Although groups with HbA1c < 6.5% and HbA1c 6.5–7% had the highest TIR (62.214 and 50.462%), their values were highly below optimal control according to CGM consensus. Groups with TBR < 5% were those with HbA1c between 6.5% and 8%. Conclusions: In our study, groups classified as well-controlled by guidelines were not consistent with good control according to the CGM consensus criteria. HbA1c should not be considered as the only parameter for metabolic control. CGM parameters allow individualized targets.
format	article
author	Rocio Porcel-Chacón Cristina Antúnez-Fernández Maria Mora Loro Ana-Belen Ariza-Jimenez Leopoldo Tapia Ceballos Jose Manuel Jimenez Hinojosa Juan Pedro Lopez-Siguero Isabel Leiva Gea
author_facet	Rocio Porcel-Chacón Cristina Antúnez-Fernández Maria Mora Loro Ana-Belen Ariza-Jimenez Leopoldo Tapia Ceballos Jose Manuel Jimenez Hinojosa Juan Pedro Lopez-Siguero Isabel Leiva Gea
author_sort	Rocio Porcel-Chacón
title	Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
title_short	Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
title_full	Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
title_fullStr	Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
title_full_unstemmed	Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?
title_sort	good metabolic control in children with type 1 diabetes mellitus: does glycated hemoglobin correlate with interstitial glucose monitoring using freestyle libre?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/99165e44ffba4a0bbba31374711f9c16
work_keys_str_mv	AT rocioporcelchacon goodmetaboliccontrolinchildrenwithtype1diabetesmellitusdoesglycatedhemoglobincorrelatewithinterstitialglucosemonitoringusingfreestylelibre AT cristinaantunezfernandez goodmetaboliccontrolinchildrenwithtype1diabetesmellitusdoesglycatedhemoglobincorrelatewithinterstitialglucosemonitoringusingfreestylelibre AT mariamoraloro goodmetaboliccontrolinchildrenwithtype1diabetesmellitusdoesglycatedhemoglobincorrelatewithinterstitialglucosemonitoringusingfreestylelibre AT anabelenarizajimenez goodmetaboliccontrolinchildrenwithtype1diabetesmellitusdoesglycatedhemoglobincorrelatewithinterstitialglucosemonitoringusingfreestylelibre AT leopoldotapiaceballos goodmetaboliccontrolinchildrenwithtype1diabetesmellitusdoesglycatedhemoglobincorrelatewithinterstitialglucosemonitoringusingfreestylelibre AT josemanueljimenezhinojosa goodmetaboliccontrolinchildrenwithtype1diabetesmellitusdoesglycatedhemoglobincorrelatewithinterstitialglucosemonitoringusingfreestylelibre AT juanpedrolopezsiguero goodmetaboliccontrolinchildrenwithtype1diabetesmellitusdoesglycatedhemoglobincorrelatewithinterstitialglucosemonitoringusingfreestylelibre AT isabelleivagea goodmetaboliccontrolinchildrenwithtype1diabetesmellitusdoesglycatedhemoglobincorrelatewithinterstitialglucosemonitoringusingfreestylelibre
_version_	1718432077701971968

Good Metabolic Control in Children with Type 1 Diabetes Mellitus: Does Glycated Hemoglobin Correlate with Interstitial Glucose Monitoring Using FreeStyle Libre?

Ejemplares similares