Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process

Francesca Anzellotti, Raffaella Franciotti, Holta Zhuzhuni, Aurelio D'Amico, Astrid Thomas, Marco Onofrj Department of Neuroscience and Imaging, Aging Research Centre, Gabriele d'Annunzio University Foundation, Gabriele d'Annunzio University, Chieti, Italy Abstract: Nonepil...

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Autores principales: Anzellotti F, Franciotti R, Zhuzhuni H, D’Amico A, Thomas A, Onofrj M
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Lenguaje:EN
Publicado: Dove Medical Press 2014
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Acceso en línea:https://doaj.org/article/991872ab1eca49f6af1832673493dff8
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spelling oai:doaj.org-article:991872ab1eca49f6af1832673493dff82021-12-02T07:09:53ZNonepileptic seizures under levetiracetam therapy: a case report of forced normalization process1178-2021https://doaj.org/article/991872ab1eca49f6af1832673493dff82014-05-01T00:00:00Zhttp://www.dovepress.com/nonepileptic-seizures-under-levetiracetam-therapy-a-case-report-of-for-a16991https://doaj.org/toc/1178-2021 Francesca Anzellotti, Raffaella Franciotti, Holta Zhuzhuni, Aurelio D'Amico, Astrid Thomas, Marco Onofrj Department of Neuroscience and Imaging, Aging Research Centre, Gabriele d'Annunzio University Foundation, Gabriele d'Annunzio University, Chieti, Italy Abstract: Nonepileptic seizures (NES) apparently look like epileptic seizures, but are not associated with ictal electrical discharges in the brain. NES constitute one of the most important differential diagnoses of epilepsy. They have been recognized as a distinctive clinical phenomenon for centuries, and video/electroencephalogram monitoring has allowed clinicians to make near-certain diagnoses. NES are supposedly unrelated to organic brain lesions, and despite the preponderance of a psychiatric/psychological context, they may have an iatrogenic origin. We report a patient with NES precipitated by levetiracetam therapy; in this case, NES was observed during the disappearance of epileptiform discharges from the routine video/electroencephalogram. We discuss the possible mechanisms underlying NES with regard to alternative psychoses associated with the phenomenon of the forced normalization process. Keywords: nonepileptic seizures, forced normalization, levetiracetam, behavioral side effectsAnzellotti FFranciotti RZhuzhuni HD’Amico AThomas AOnofrj MDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2014, Iss default, Pp 959-964 (2014)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Anzellotti F
Franciotti R
Zhuzhuni H
D’Amico A
Thomas A
Onofrj M
Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
description Francesca Anzellotti, Raffaella Franciotti, Holta Zhuzhuni, Aurelio D'Amico, Astrid Thomas, Marco Onofrj Department of Neuroscience and Imaging, Aging Research Centre, Gabriele d'Annunzio University Foundation, Gabriele d'Annunzio University, Chieti, Italy Abstract: Nonepileptic seizures (NES) apparently look like epileptic seizures, but are not associated with ictal electrical discharges in the brain. NES constitute one of the most important differential diagnoses of epilepsy. They have been recognized as a distinctive clinical phenomenon for centuries, and video/electroencephalogram monitoring has allowed clinicians to make near-certain diagnoses. NES are supposedly unrelated to organic brain lesions, and despite the preponderance of a psychiatric/psychological context, they may have an iatrogenic origin. We report a patient with NES precipitated by levetiracetam therapy; in this case, NES was observed during the disappearance of epileptiform discharges from the routine video/electroencephalogram. We discuss the possible mechanisms underlying NES with regard to alternative psychoses associated with the phenomenon of the forced normalization process. Keywords: nonepileptic seizures, forced normalization, levetiracetam, behavioral side effects
format article
author Anzellotti F
Franciotti R
Zhuzhuni H
D’Amico A
Thomas A
Onofrj M
author_facet Anzellotti F
Franciotti R
Zhuzhuni H
D’Amico A
Thomas A
Onofrj M
author_sort Anzellotti F
title Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
title_short Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
title_full Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
title_fullStr Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
title_full_unstemmed Nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
title_sort nonepileptic seizures under levetiracetam therapy: a case report of forced normalization process
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/991872ab1eca49f6af1832673493dff8
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