Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein

Human cytomegalovirus (CMV) poses a risk for immunosuppressed patients and newborns, with limited treatment options available. Here, Gardneret al. use a high-throughput approach and identify monoclonal antibodies that bind a highly conserved domain in the viral glycoprotein gH as potent inhibitors o...

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Autores principales:	Thomas J. Gardner, Kathryn R. Stein, J. Andrew Duty, Toni M. Schwarz, Vanessa M. Noriega, Thomas Kraus, Thomas M. Moran, Domenico Tortorella
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/991bb8c974f040b5b045baf0a89ab897
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spelling	oai:doaj.org-article:991bb8c974f040b5b045baf0a89ab8972021-12-02T17:32:07ZFunctional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein10.1038/ncomms136272041-1723https://doaj.org/article/991bb8c974f040b5b045baf0a89ab8972016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13627https://doaj.org/toc/2041-1723Human cytomegalovirus (CMV) poses a risk for immunosuppressed patients and newborns, with limited treatment options available. Here, Gardneret al. use a high-throughput approach and identify monoclonal antibodies that bind a highly conserved domain in the viral glycoprotein gH as potent inhibitors of CMV infection.Thomas J. GardnerKathryn R. SteinJ. Andrew DutyToni M. SchwarzVanessa M. NoriegaThomas KrausThomas M. MoranDomenico TortorellaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas J. Gardner Kathryn R. Stein J. Andrew Duty Toni M. Schwarz Vanessa M. Noriega Thomas Kraus Thomas M. Moran Domenico Tortorella Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein
description	Human cytomegalovirus (CMV) poses a risk for immunosuppressed patients and newborns, with limited treatment options available. Here, Gardneret al. use a high-throughput approach and identify monoclonal antibodies that bind a highly conserved domain in the viral glycoprotein gH as potent inhibitors of CMV infection.
format	article
author	Thomas J. Gardner Kathryn R. Stein J. Andrew Duty Toni M. Schwarz Vanessa M. Noriega Thomas Kraus Thomas M. Moran Domenico Tortorella
author_facet	Thomas J. Gardner Kathryn R. Stein J. Andrew Duty Toni M. Schwarz Vanessa M. Noriega Thomas Kraus Thomas M. Moran Domenico Tortorella
author_sort	Thomas J. Gardner
title	Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein
title_short	Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein
title_full	Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein
title_fullStr	Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein
title_full_unstemmed	Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein
title_sort	functional screening for anti-cmv biologics identifies a broadly neutralizing epitope of an essential envelope protein
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/991bb8c974f040b5b045baf0a89ab897
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Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein

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