Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein
Human cytomegalovirus (CMV) poses a risk for immunosuppressed patients and newborns, with limited treatment options available. Here, Gardneret al. use a high-throughput approach and identify monoclonal antibodies that bind a highly conserved domain in the viral glycoprotein gH as potent inhibitors o...
Saved in:
Main Authors: | Thomas J. Gardner, Kathryn R. Stein, J. Andrew Duty, Toni M. Schwarz, Vanessa M. Noriega, Thomas Kraus, Thomas M. Moran, Domenico Tortorella |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2016
|
Subjects: | |
Online Access: | https://doaj.org/article/991bb8c974f040b5b045baf0a89ab897 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
CD46 facilitates entry and dissemination of human cytomegalovirus
by: Kathryn R. Stein, et al.
Published: (2019) -
HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope
by: Daniela Fera, et al.
Published: (2018) -
Computational prediction of broadly neutralizing HIV-1 antibody epitopes from neutralization activity data.
by: Andrew L Ferguson, et al.
Published: (2013) -
The Potent and Broadly Neutralizing Human Dengue Virus-Specific Monoclonal Antibody 1C19 Reveals a Unique Cross-Reactive Epitope on the bc Loop of Domain II of the Envelope Protein
by: Scott A. Smith, et al.
Published: (2013) -
Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding
by: Daniel W. Kulp, et al.
Published: (2017)