Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso.

<h4>Objectives</h4>To evaluate the impact of anti-malaria biological larviciding with Bacillus thuringiensis israelensis on non-primary target mosquito species in a rural African setting.<h4>Methods</h4>A total of 127 villages were distributed in three study arms, each with d...

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Autores principales:	Peter Dambach, Till Bärnighausen, Anges Yadouleton, Martin Dambach, Issouf Traoré, Patricia Korir, Saidou Ouedraogo, Moustapha Nikiema, Rainer Sauerborn, Norbert Becker, Valérie R Louis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/991d1e6827a84e1b98ecd555f029928e
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spelling	oai:doaj.org-article:991d1e6827a84e1b98ecd555f029928e2021-12-02T20:10:22ZIs biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso.1932-620310.1371/journal.pone.0253597https://doaj.org/article/991d1e6827a84e1b98ecd555f029928e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253597https://doaj.org/toc/1932-6203<h4>Objectives</h4>To evaluate the impact of anti-malaria biological larviciding with Bacillus thuringiensis israelensis on non-primary target mosquito species in a rural African setting.<h4>Methods</h4>A total of 127 villages were distributed in three study arms, each with different larviciding options in public spaces: i) no treatment, ii) full or iii) guided intervention. Geographically close villages were grouped in clusters to avoid contamination between treated and untreated villages. Adult mosquitoes were captured in light traps inside and outside houses during the rainy seasons of a baseline and an intervention year. After enumeration, a negative binomial regression was used to determine the reductions achieved in the different mosquito species through larviciding.<h4>Results</h4>Malaria larviciding interventions showed only limited or no impact against Culex mosquitoes; by contrast, reductions of up to 34% were achieved against Aedes when all detected breeding sites were treated. Culex mosquitoes were captured in high abundance in semi-urban settings while more Aedes were found in rural villages.<h4>Conclusions</h4>Future malaria larviciding programs should consider expanding onto the breeding habitats of other disease vectors, such as Aedes and Culex and evaluate their potential impact. Since the major cost components of such interventions are labor and transport, other disease vectors could be targeted at little additional cost.Peter DambachTill BärnighausenAnges YadouletonMartin DambachIssouf TraoréPatricia KorirSaidou OuedraogoMoustapha NikiemaRainer SauerbornNorbert BeckerValérie R LouisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253597 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter Dambach Till Bärnighausen Anges Yadouleton Martin Dambach Issouf Traoré Patricia Korir Saidou Ouedraogo Moustapha Nikiema Rainer Sauerborn Norbert Becker Valérie R Louis Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso.
description	<h4>Objectives</h4>To evaluate the impact of anti-malaria biological larviciding with Bacillus thuringiensis israelensis on non-primary target mosquito species in a rural African setting.<h4>Methods</h4>A total of 127 villages were distributed in three study arms, each with different larviciding options in public spaces: i) no treatment, ii) full or iii) guided intervention. Geographically close villages were grouped in clusters to avoid contamination between treated and untreated villages. Adult mosquitoes were captured in light traps inside and outside houses during the rainy seasons of a baseline and an intervention year. After enumeration, a negative binomial regression was used to determine the reductions achieved in the different mosquito species through larviciding.<h4>Results</h4>Malaria larviciding interventions showed only limited or no impact against Culex mosquitoes; by contrast, reductions of up to 34% were achieved against Aedes when all detected breeding sites were treated. Culex mosquitoes were captured in high abundance in semi-urban settings while more Aedes were found in rural villages.<h4>Conclusions</h4>Future malaria larviciding programs should consider expanding onto the breeding habitats of other disease vectors, such as Aedes and Culex and evaluate their potential impact. Since the major cost components of such interventions are labor and transport, other disease vectors could be targeted at little additional cost.
format	article
author	Peter Dambach Till Bärnighausen Anges Yadouleton Martin Dambach Issouf Traoré Patricia Korir Saidou Ouedraogo Moustapha Nikiema Rainer Sauerborn Norbert Becker Valérie R Louis
author_facet	Peter Dambach Till Bärnighausen Anges Yadouleton Martin Dambach Issouf Traoré Patricia Korir Saidou Ouedraogo Moustapha Nikiema Rainer Sauerborn Norbert Becker Valérie R Louis
author_sort	Peter Dambach
title	Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso.
title_short	Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso.
title_full	Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso.
title_fullStr	Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso.
title_full_unstemmed	Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso.
title_sort	is biological larviciding against malaria a starting point for integrated multi-disease control? observations from a cluster randomized trial in rural burkina faso.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/991d1e6827a84e1b98ecd555f029928e
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Is biological larviciding against malaria a starting point for integrated multi-disease control? Observations from a cluster randomized trial in rural Burkina Faso.

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