Effect of Temporal Difference on Clinical Outcomes of Patients with Out-of-Hospital Cardiac Arrest: A Retrospective Study from an Urban City of Taiwan

Circadian pattern influence on the incidence of out-of-hospital cardiac arrest (OHCA) has been demonstrated. However, the effect of temporal difference on the clinical outcomes of OHCA remains inconclusive. Therefore, we conducted a retrospective study in an urban city of Taiwan between January 2018...

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Autores principales:	Han-Chun Huang, Tsung-Yu Lee, Cheng-Han Tsai, Yao-Sing Su, Yi-Rong Chen, Ya-Ni Yeh, Chi-Feng Hsu, Ming-Jen Tsai
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	out-of-hospital cardiac arrest temporal difference circadian variation nighttime survival return of spontaneous circulation Medicine R
Acceso en línea:	https://doaj.org/article/991e0c76bdc942dd93f79cd7171de554
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spelling	oai:doaj.org-article:991e0c76bdc942dd93f79cd7171de5542021-11-11T16:10:43ZEffect of Temporal Difference on Clinical Outcomes of Patients with Out-of-Hospital Cardiac Arrest: A Retrospective Study from an Urban City of Taiwan10.3390/ijerph1821110201660-46011661-7827https://doaj.org/article/991e0c76bdc942dd93f79cd7171de5542021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11020https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Circadian pattern influence on the incidence of out-of-hospital cardiac arrest (OHCA) has been demonstrated. However, the effect of temporal difference on the clinical outcomes of OHCA remains inconclusive. Therefore, we conducted a retrospective study in an urban city of Taiwan between January 2018 and December 2020 in order to investigate the relationship between temporal differences and the return of spontaneous circulation (ROSC), sustained (≥24 h) ROSC, and survival to discharge in patients with OHCA. Of the 842 patients with OHCA, 371 occurred in the daytime, 250 in the evening, and 221 at night. During nighttime, there was a decreased incidence of OHCA, but the outcomes of OHCA were significant poor compared to the incidents during the daytime and evening. After multivariate adjustment for influencing factors, OHCAs occurring at night were independently associated with lower probabilities of achieving sustained ROSC (aOR = 0.489, 95% CI: 0.285–0.840, <i>p</i> = 0.009) and survival to discharge (aOR = 0.147, 95% CI: 0.03–0.714, <i>p</i> = 0.017). Subgroup analyses revealed significant temporal differences in male patients, older adult patients, those with longer response times (≥5 min), and witnessed OHCA. The effects of temporal difference on the outcome of OHCA may be a result of physiological factors, underlying etiology of arrest, resuscitative efforts in prehospital and in-hospital stages, or a combination of factors.Han-Chun HuangTsung-Yu LeeCheng-Han TsaiYao-Sing SuYi-Rong ChenYa-Ni YehChi-Feng HsuMing-Jen TsaiMDPI AGarticleout-of-hospital cardiac arresttemporal differencecircadian variationnighttimesurvivalreturn of spontaneous circulationMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11020, p 11020 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	out-of-hospital cardiac arrest temporal difference circadian variation nighttime survival return of spontaneous circulation Medicine R
spellingShingle	out-of-hospital cardiac arrest temporal difference circadian variation nighttime survival return of spontaneous circulation Medicine R Han-Chun Huang Tsung-Yu Lee Cheng-Han Tsai Yao-Sing Su Yi-Rong Chen Ya-Ni Yeh Chi-Feng Hsu Ming-Jen Tsai Effect of Temporal Difference on Clinical Outcomes of Patients with Out-of-Hospital Cardiac Arrest: A Retrospective Study from an Urban City of Taiwan
description	Circadian pattern influence on the incidence of out-of-hospital cardiac arrest (OHCA) has been demonstrated. However, the effect of temporal difference on the clinical outcomes of OHCA remains inconclusive. Therefore, we conducted a retrospective study in an urban city of Taiwan between January 2018 and December 2020 in order to investigate the relationship between temporal differences and the return of spontaneous circulation (ROSC), sustained (≥24 h) ROSC, and survival to discharge in patients with OHCA. Of the 842 patients with OHCA, 371 occurred in the daytime, 250 in the evening, and 221 at night. During nighttime, there was a decreased incidence of OHCA, but the outcomes of OHCA were significant poor compared to the incidents during the daytime and evening. After multivariate adjustment for influencing factors, OHCAs occurring at night were independently associated with lower probabilities of achieving sustained ROSC (aOR = 0.489, 95% CI: 0.285–0.840, <i>p</i> = 0.009) and survival to discharge (aOR = 0.147, 95% CI: 0.03–0.714, <i>p</i> = 0.017). Subgroup analyses revealed significant temporal differences in male patients, older adult patients, those with longer response times (≥5 min), and witnessed OHCA. The effects of temporal difference on the outcome of OHCA may be a result of physiological factors, underlying etiology of arrest, resuscitative efforts in prehospital and in-hospital stages, or a combination of factors.
format	article
author	Han-Chun Huang Tsung-Yu Lee Cheng-Han Tsai Yao-Sing Su Yi-Rong Chen Ya-Ni Yeh Chi-Feng Hsu Ming-Jen Tsai
author_facet	Han-Chun Huang Tsung-Yu Lee Cheng-Han Tsai Yao-Sing Su Yi-Rong Chen Ya-Ni Yeh Chi-Feng Hsu Ming-Jen Tsai
author_sort	Han-Chun Huang
title	Effect of Temporal Difference on Clinical Outcomes of Patients with Out-of-Hospital Cardiac Arrest: A Retrospective Study from an Urban City of Taiwan
title_short	Effect of Temporal Difference on Clinical Outcomes of Patients with Out-of-Hospital Cardiac Arrest: A Retrospective Study from an Urban City of Taiwan
title_full	Effect of Temporal Difference on Clinical Outcomes of Patients with Out-of-Hospital Cardiac Arrest: A Retrospective Study from an Urban City of Taiwan
title_fullStr	Effect of Temporal Difference on Clinical Outcomes of Patients with Out-of-Hospital Cardiac Arrest: A Retrospective Study from an Urban City of Taiwan
title_full_unstemmed	Effect of Temporal Difference on Clinical Outcomes of Patients with Out-of-Hospital Cardiac Arrest: A Retrospective Study from an Urban City of Taiwan
title_sort	effect of temporal difference on clinical outcomes of patients with out-of-hospital cardiac arrest: a retrospective study from an urban city of taiwan
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/991e0c76bdc942dd93f79cd7171de554
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Effect of Temporal Difference on Clinical Outcomes of Patients with Out-of-Hospital Cardiac Arrest: A Retrospective Study from an Urban City of Taiwan

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