Experimental human pneumococcal carriage augments IL-17A-dependent T-cell defence of the lung.

Experimental human pneumococcal carriage augments IL-17A-dependent T-cell defence of the lung.

Pneumococcal carriage is both immunising and a pre-requisite for mucosal and systemic disease. Murine models of pneumococcal colonisation show that IL-17A-secreting CD4(+) T-cells (Th-17 cells) are essential for clearance of pneumococci from the nasopharynx. Pneumococcal-responding IL-17A-secreting...

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Autores principales: Adam K A Wright, Mathieu Bangert, Jenna F Gritzfeld, Daniela M Ferreira, Kondwani C Jambo, Angela D Wright, Andrea M Collins, Stephen B Gordon
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/991ee9a5e40343629520074aa869eb22
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