Early protein intake predicts functional connectivity and neurocognition in preterm born children

Abstract Nutritional intake can promote early neonatal brain development in very preterm born neonates (< 32 weeks’ gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whether early nutrient intake in the first weeks of life would be associated with l...

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Autores principales:	Emma G. Duerden, Benjamin Thompson, Tanya Poppe, Jane Alsweiler, Greg Gamble, Yannan Jiang, Myra Leung, Anna C. Tottman, Trecia Wouldes, Steven P. Miller, Jane E. Harding, PIANO study group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/991f195e8af24d70b5a5ff53880462a6
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spelling	oai:doaj.org-article:991f195e8af24d70b5a5ff53880462a62021-12-02T10:54:14ZEarly protein intake predicts functional connectivity and neurocognition in preterm born children10.1038/s41598-021-83125-z2045-2322https://doaj.org/article/991f195e8af24d70b5a5ff53880462a62021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83125-zhttps://doaj.org/toc/2045-2322Abstract Nutritional intake can promote early neonatal brain development in very preterm born neonates (< 32 weeks’ gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whether early nutrient intake in the first weeks of life would be associated with long-term brain function and neurocognitive skills at school age. Children underwent resting-state functional MRI (fMRI), intelligence testing (Wechsler Intelligence Scale for Children, 5th Ed) and visual-motor processing (Beery-Buktenica, 5th Ed) at 7 years. Relationships were assessed between neonatal macronutrient intakes, functional connectivity strength between thalamic and default mode networks (DMN), and neuro-cognitive function using multivariable regression. Greater functional connectivity strength between thalamic networks and DMN was associated with greater intake of protein in the first week (β = 0.17; 95% CI 0.11, 0.23, p < 0.001) but lower intakes of fat (β = − 0.06; 95% CI − 0.09, − 0.02, p = 0.001) and carbohydrates (β = − 0.03; 95% CI − 0.04, − 0.01, p = 0.003). Connectivity strength was also associated with protein intake during the first month (β = 0.22; 95% CI 0.06, 0.37, p = 0.006). Importantly, greater thalamic-DMN connectivity strength was associated with higher processing speed indices (β = 26.9; 95% CI 4.21, 49.49, p = 0.02) and visual processing scores (β = 9.03; 95% CI 2.27, 15.79, p = 0.009). Optimizing early protein intake may contribute to promoting long-term brain health in preterm-born children.Emma G. DuerdenBenjamin ThompsonTanya PoppeJane AlsweilerGreg GambleYannan JiangMyra LeungAnna C. TottmanTrecia WouldesSteven P. MillerJane E. HardingPIANO study groupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emma G. Duerden Benjamin Thompson Tanya Poppe Jane Alsweiler Greg Gamble Yannan Jiang Myra Leung Anna C. Tottman Trecia Wouldes Steven P. Miller Jane E. Harding PIANO study group Early protein intake predicts functional connectivity and neurocognition in preterm born children
description	Abstract Nutritional intake can promote early neonatal brain development in very preterm born neonates (< 32 weeks’ gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whether early nutrient intake in the first weeks of life would be associated with long-term brain function and neurocognitive skills at school age. Children underwent resting-state functional MRI (fMRI), intelligence testing (Wechsler Intelligence Scale for Children, 5th Ed) and visual-motor processing (Beery-Buktenica, 5th Ed) at 7 years. Relationships were assessed between neonatal macronutrient intakes, functional connectivity strength between thalamic and default mode networks (DMN), and neuro-cognitive function using multivariable regression. Greater functional connectivity strength between thalamic networks and DMN was associated with greater intake of protein in the first week (β = 0.17; 95% CI 0.11, 0.23, p < 0.001) but lower intakes of fat (β = − 0.06; 95% CI − 0.09, − 0.02, p = 0.001) and carbohydrates (β = − 0.03; 95% CI − 0.04, − 0.01, p = 0.003). Connectivity strength was also associated with protein intake during the first month (β = 0.22; 95% CI 0.06, 0.37, p = 0.006). Importantly, greater thalamic-DMN connectivity strength was associated with higher processing speed indices (β = 26.9; 95% CI 4.21, 49.49, p = 0.02) and visual processing scores (β = 9.03; 95% CI 2.27, 15.79, p = 0.009). Optimizing early protein intake may contribute to promoting long-term brain health in preterm-born children.
format	article
author	Emma G. Duerden Benjamin Thompson Tanya Poppe Jane Alsweiler Greg Gamble Yannan Jiang Myra Leung Anna C. Tottman Trecia Wouldes Steven P. Miller Jane E. Harding PIANO study group
author_facet	Emma G. Duerden Benjamin Thompson Tanya Poppe Jane Alsweiler Greg Gamble Yannan Jiang Myra Leung Anna C. Tottman Trecia Wouldes Steven P. Miller Jane E. Harding PIANO study group
author_sort	Emma G. Duerden
title	Early protein intake predicts functional connectivity and neurocognition in preterm born children
title_short	Early protein intake predicts functional connectivity and neurocognition in preterm born children
title_full	Early protein intake predicts functional connectivity and neurocognition in preterm born children
title_fullStr	Early protein intake predicts functional connectivity and neurocognition in preterm born children
title_full_unstemmed	Early protein intake predicts functional connectivity and neurocognition in preterm born children
title_sort	early protein intake predicts functional connectivity and neurocognition in preterm born children
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/991f195e8af24d70b5a5ff53880462a6
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_version_	1718396484403068928

Early protein intake predicts functional connectivity and neurocognition in preterm born children

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