Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia

Abstract Despite recent advances in chemotherapy for gastrointestinal cancer, a crucial factor related to poor prognosis is reduced tolerance to chemotherapy induced by cancer cachexia. Fish oil (FO)-derived eicosapentaenoic acid (EPA) modulates inflammation in patients with various malignancies; ho...

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Autores principales:	Yumiko Shirai, Yoshinaga Okugawa, Asahi Hishida, Aki Ogawa, Kyoko Okamoto, Miki Shintani, Yuki Morimoto, Ryutaro Nishikawa, Takeshi Yokoe, Koji Tanaka, Hisashi Urata, Yuji Toiyama, Yasuhiro Inoue, Motoyoshi Tanaka, Yasuhiko Mohri, Ajay Goel, Masato Kusunoki, Donald C. McMillan, Chikao Miki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/99229cdd1bcb4200bd32214a7014fbb3
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spelling	oai:doaj.org-article:99229cdd1bcb4200bd32214a7014fbb32021-12-02T12:31:49ZFish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia10.1038/s41598-017-05278-02045-2322https://doaj.org/article/99229cdd1bcb4200bd32214a7014fbb32017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05278-0https://doaj.org/toc/2045-2322Abstract Despite recent advances in chemotherapy for gastrointestinal cancer, a crucial factor related to poor prognosis is reduced tolerance to chemotherapy induced by cancer cachexia. Fish oil (FO)-derived eicosapentaenoic acid (EPA) modulates inflammation in patients with various malignancies; however, the impact of FO-enriched nutrition as a combined modality therapy on clinical outcomes remains controversial. We systemically analysed chronological changes in biochemical and physiological status using bioelectrical impedance analysis in 128 gastrointestinal cancer patients provided with or without FO-enriched nutrition during chemotherapy. Furthermore, we evaluated the clinical significance of FO-enriched nutrition and clarified appropriate patient groups that receive prognostic benefits from FO-enriched nutrition during treatment of gastrointestinal cancer. The control group showed significant up-regulation of serum CRP) levels and no significant difference in both skeletal muscle mass and lean body mass. In contrast, the FO-enriched nutrition group showed no changes in serum CRP concentration and significantly increased skeletal muscle mass and lean body mass over time. Furthermore, high CRP levels significantly correlated with reduced tolerance to chemotherapy, and FO-enriched nutrition improved chemotherapy tolerance and prognosis, particularly in gastrointestinal cancer patients with a modified Glasgow prognostic score (mGPS) of 1 or 2. We conclude that FO-enriched nutrition may improve the prognosis of patients with cancer cachexia and systemic inflammation (i.e., those with a mGPS of 1 or 2).Yumiko ShiraiYoshinaga OkugawaAsahi HishidaAki OgawaKyoko OkamotoMiki ShintaniYuki MorimotoRyutaro NishikawaTakeshi YokoeKoji TanakaHisashi UrataYuji ToiyamaYasuhiro InoueMotoyoshi TanakaYasuhiko MohriAjay GoelMasato KusunokiDonald C. McMillanChikao MikiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yumiko Shirai Yoshinaga Okugawa Asahi Hishida Aki Ogawa Kyoko Okamoto Miki Shintani Yuki Morimoto Ryutaro Nishikawa Takeshi Yokoe Koji Tanaka Hisashi Urata Yuji Toiyama Yasuhiro Inoue Motoyoshi Tanaka Yasuhiko Mohri Ajay Goel Masato Kusunoki Donald C. McMillan Chikao Miki Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia
description	Abstract Despite recent advances in chemotherapy for gastrointestinal cancer, a crucial factor related to poor prognosis is reduced tolerance to chemotherapy induced by cancer cachexia. Fish oil (FO)-derived eicosapentaenoic acid (EPA) modulates inflammation in patients with various malignancies; however, the impact of FO-enriched nutrition as a combined modality therapy on clinical outcomes remains controversial. We systemically analysed chronological changes in biochemical and physiological status using bioelectrical impedance analysis in 128 gastrointestinal cancer patients provided with or without FO-enriched nutrition during chemotherapy. Furthermore, we evaluated the clinical significance of FO-enriched nutrition and clarified appropriate patient groups that receive prognostic benefits from FO-enriched nutrition during treatment of gastrointestinal cancer. The control group showed significant up-regulation of serum CRP) levels and no significant difference in both skeletal muscle mass and lean body mass. In contrast, the FO-enriched nutrition group showed no changes in serum CRP concentration and significantly increased skeletal muscle mass and lean body mass over time. Furthermore, high CRP levels significantly correlated with reduced tolerance to chemotherapy, and FO-enriched nutrition improved chemotherapy tolerance and prognosis, particularly in gastrointestinal cancer patients with a modified Glasgow prognostic score (mGPS) of 1 or 2. We conclude that FO-enriched nutrition may improve the prognosis of patients with cancer cachexia and systemic inflammation (i.e., those with a mGPS of 1 or 2).
format	article
author	Yumiko Shirai Yoshinaga Okugawa Asahi Hishida Aki Ogawa Kyoko Okamoto Miki Shintani Yuki Morimoto Ryutaro Nishikawa Takeshi Yokoe Koji Tanaka Hisashi Urata Yuji Toiyama Yasuhiro Inoue Motoyoshi Tanaka Yasuhiko Mohri Ajay Goel Masato Kusunoki Donald C. McMillan Chikao Miki
author_facet	Yumiko Shirai Yoshinaga Okugawa Asahi Hishida Aki Ogawa Kyoko Okamoto Miki Shintani Yuki Morimoto Ryutaro Nishikawa Takeshi Yokoe Koji Tanaka Hisashi Urata Yuji Toiyama Yasuhiro Inoue Motoyoshi Tanaka Yasuhiko Mohri Ajay Goel Masato Kusunoki Donald C. McMillan Chikao Miki
author_sort	Yumiko Shirai
title	Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia
title_short	Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia
title_full	Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia
title_fullStr	Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia
title_full_unstemmed	Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia
title_sort	fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/99229cdd1bcb4200bd32214a7014fbb3
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Fish oil-enriched nutrition combined with systemic chemotherapy for gastrointestinal cancer patients with cancer cachexia

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