CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

Genetically engineered T cells expressing a chimeric antigen receptor (CAR-T cells) are a promising new treatment for cancer, but are associated with unique toxicities. Here, the authors test CAR-T-cell-derived exosomes as a surrogate for CAR-T cells and show that they can elicit a potent antitumour...

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Autores principales:	Wenyan Fu, Changhai Lei, Shuowu Liu, Yingshu Cui, Chuqi Wang, Kewen Qian, Tian Li, Yafeng Shen, Xiaoyan Fan, Fangxing Lin, Min Ding, Mingzhu Pan, Xuting Ye, Yongji Yang, Shi Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9922d9f362cb422ca19401f860eaed83
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spelling	oai:doaj.org-article:9922d9f362cb422ca19401f860eaed832021-12-02T15:35:16ZCAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity10.1038/s41467-019-12321-32041-1723https://doaj.org/article/9922d9f362cb422ca19401f860eaed832019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12321-3https://doaj.org/toc/2041-1723Genetically engineered T cells expressing a chimeric antigen receptor (CAR-T cells) are a promising new treatment for cancer, but are associated with unique toxicities. Here, the authors test CAR-T-cell-derived exosomes as a surrogate for CAR-T cells and show that they can elicit a potent antitumour immune response in preclinical models of breast cancer with reduced signs of cytokine release syndrome compared with CAR-T therapy.Wenyan FuChanghai LeiShuowu LiuYingshu CuiChuqi WangKewen QianTian LiYafeng ShenXiaoyan FanFangxing LinMin DingMingzhu PanXuting YeYongji YangShi HuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenyan Fu Changhai Lei Shuowu Liu Yingshu Cui Chuqi Wang Kewen Qian Tian Li Yafeng Shen Xiaoyan Fan Fangxing Lin Min Ding Mingzhu Pan Xuting Ye Yongji Yang Shi Hu CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
description	Genetically engineered T cells expressing a chimeric antigen receptor (CAR-T cells) are a promising new treatment for cancer, but are associated with unique toxicities. Here, the authors test CAR-T-cell-derived exosomes as a surrogate for CAR-T cells and show that they can elicit a potent antitumour immune response in preclinical models of breast cancer with reduced signs of cytokine release syndrome compared with CAR-T therapy.
format	article
author	Wenyan Fu Changhai Lei Shuowu Liu Yingshu Cui Chuqi Wang Kewen Qian Tian Li Yafeng Shen Xiaoyan Fan Fangxing Lin Min Ding Mingzhu Pan Xuting Ye Yongji Yang Shi Hu
author_facet	Wenyan Fu Changhai Lei Shuowu Liu Yingshu Cui Chuqi Wang Kewen Qian Tian Li Yafeng Shen Xiaoyan Fan Fangxing Lin Min Ding Mingzhu Pan Xuting Ye Yongji Yang Shi Hu
author_sort	Wenyan Fu
title	CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
title_short	CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
title_full	CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
title_fullStr	CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
title_full_unstemmed	CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
title_sort	car exosomes derived from effector car-t cells have potent antitumour effects and low toxicity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9922d9f362cb422ca19401f860eaed83
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CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

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