CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

Genetically engineered T cells expressing a chimeric antigen receptor (CAR-T cells) are a promising new treatment for cancer, but are associated with unique toxicities. Here, the authors test CAR-T-cell-derived exosomes as a surrogate for CAR-T cells and show that they can elicit a potent antitumour...

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Autores principales: Wenyan Fu, Changhai Lei, Shuowu Liu, Yingshu Cui, Chuqi Wang, Kewen Qian, Tian Li, Yafeng Shen, Xiaoyan Fan, Fangxing Lin, Min Ding, Mingzhu Pan, Xuting Ye, Yongji Yang, Shi Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/9922d9f362cb422ca19401f860eaed83
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