Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis

Hirschsprung-associated enterocolitis (HAEC) is a common life-threatening complication of Hirschsprung disease (HSCR). It has been proposed that gut microbiota, which have an essential role in gut-homeostasis, are associated with HAEC. Recent studies demonstrated an increase in alpha diversity of fe...

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Autores principales:	Sireekarn Chantakhow, Jiraporn Khorana, Kanokkan Tepmalai, Nonglak Boonchooduang, Nipon Chattipakorn, Siriporn C. Chattipakorn
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Hirschsprung aganglionosis enterocolitis gut microbiota microbiome Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/99250e54f29a4260ac1e6346d03f2144
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spelling	oai:doaj.org-article:99250e54f29a4260ac1e6346d03f21442021-11-25T18:24:31ZAlterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis10.3390/microorganisms91122412076-2607https://doaj.org/article/99250e54f29a4260ac1e6346d03f21442021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2241https://doaj.org/toc/2076-2607Hirschsprung-associated enterocolitis (HAEC) is a common life-threatening complication of Hirschsprung disease (HSCR). It has been proposed that gut microbiota, which have an essential role in gut-homeostasis, are associated with HAEC. Recent studies demonstrated an increase in alpha diversity of fecal microbiota over time in HSCR mice and a decrease in diversity after surgery. In addition, clinical studies have reported a reduction in bacterial richness in HSCR children after surgery. Some studies revealed a difference in microbiota between the proximal ganglionic and distal aganglionic intestine and found a difference in bacterial character between fecal and colonic specimens. HAEC studies found an increase in <i>Proteobacteria</i>, especially <i>Escherichia</i> and <i>Enterobacteriaceae</i>, with a decrease in <i>Firmicutes</i> and <i>Bifidobacterium</i> in HAEC patients. However, the direction of alpha diversity in HAEC patients is still controversial. The self-comparison of microbiota in treatment periods suggested that probiotics might improve gut dysbiosis and decrease the frequency of enterocolitis, but some reported contradictory findings. This review comprehensively summarizes and discusses key findings from animal and clinical data of the distinct microbiome associated with HCSR and the association of gut dysbiosis with the development of HAEC. This information should be useful in the establishment of novel interventions to improve gut dysbiosis and prevent enterocolitis in HSCR patients.Sireekarn ChantakhowJiraporn KhoranaKanokkan TepmalaiNonglak BoonchooduangNipon ChattipakornSiriporn C. ChattipakornMDPI AGarticleHirschsprungaganglionosisenterocolitisgut microbiotamicrobiomeBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2241, p 2241 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hirschsprung aganglionosis enterocolitis gut microbiota microbiome Biology (General) QH301-705.5
spellingShingle	Hirschsprung aganglionosis enterocolitis gut microbiota microbiome Biology (General) QH301-705.5 Sireekarn Chantakhow Jiraporn Khorana Kanokkan Tepmalai Nonglak Boonchooduang Nipon Chattipakorn Siriporn C. Chattipakorn Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis
description	Hirschsprung-associated enterocolitis (HAEC) is a common life-threatening complication of Hirschsprung disease (HSCR). It has been proposed that gut microbiota, which have an essential role in gut-homeostasis, are associated with HAEC. Recent studies demonstrated an increase in alpha diversity of fecal microbiota over time in HSCR mice and a decrease in diversity after surgery. In addition, clinical studies have reported a reduction in bacterial richness in HSCR children after surgery. Some studies revealed a difference in microbiota between the proximal ganglionic and distal aganglionic intestine and found a difference in bacterial character between fecal and colonic specimens. HAEC studies found an increase in <i>Proteobacteria</i>, especially <i>Escherichia</i> and <i>Enterobacteriaceae</i>, with a decrease in <i>Firmicutes</i> and <i>Bifidobacterium</i> in HAEC patients. However, the direction of alpha diversity in HAEC patients is still controversial. The self-comparison of microbiota in treatment periods suggested that probiotics might improve gut dysbiosis and decrease the frequency of enterocolitis, but some reported contradictory findings. This review comprehensively summarizes and discusses key findings from animal and clinical data of the distinct microbiome associated with HCSR and the association of gut dysbiosis with the development of HAEC. This information should be useful in the establishment of novel interventions to improve gut dysbiosis and prevent enterocolitis in HSCR patients.
format	article
author	Sireekarn Chantakhow Jiraporn Khorana Kanokkan Tepmalai Nonglak Boonchooduang Nipon Chattipakorn Siriporn C. Chattipakorn
author_facet	Sireekarn Chantakhow Jiraporn Khorana Kanokkan Tepmalai Nonglak Boonchooduang Nipon Chattipakorn Siriporn C. Chattipakorn
author_sort	Sireekarn Chantakhow
title	Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis
title_short	Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis
title_full	Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis
title_fullStr	Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis
title_full_unstemmed	Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis
title_sort	alterations of gut bacteria in hirschsprung disease and hirschsprung-associated enterocolitis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/99250e54f29a4260ac1e6346d03f2144
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Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis

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