Highly dampened blood transcriptome response in HIV patients after influenza infection

Abstract Respiratory viral (RV) infections represent a major threat for human health worldwide. Persons with HIV (PWH) have a compromised immune response and are thought to be at higher risk for severe RV disease. However, very little is known about the host immune response to RV infection in PWH. H...

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Autores principales:	Subhashini A. Sellers, William A. Fischer, Mark T. Heise, Klaus Schughart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/99258aa0f02e4fc18694a57eb7cb7a30
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spelling	oai:doaj.org-article:99258aa0f02e4fc18694a57eb7cb7a302021-12-02T11:37:18ZHighly dampened blood transcriptome response in HIV patients after influenza infection10.1038/s41598-021-83876-92045-2322https://doaj.org/article/99258aa0f02e4fc18694a57eb7cb7a302021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83876-9https://doaj.org/toc/2045-2322Abstract Respiratory viral (RV) infections represent a major threat for human health worldwide. Persons with HIV (PWH) have a compromised immune response and are thought to be at higher risk for severe RV disease. However, very little is known about the host immune response to RV infection in PWH. Here, we investigated gene expression changes in the peripheral blood of PWH co-infected with RV. Only very few differentially expressed genes could be detected between PWH with and without RV infection, suggesting that the immune response to RV in PWH is strongly dampened. Our data provides important insights into the host response to RV infections in HIV patients.Subhashini A. SellersWilliam A. FischerMark T. HeiseKlaus SchughartNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Subhashini A. Sellers William A. Fischer Mark T. Heise Klaus Schughart Highly dampened blood transcriptome response in HIV patients after influenza infection
description	Abstract Respiratory viral (RV) infections represent a major threat for human health worldwide. Persons with HIV (PWH) have a compromised immune response and are thought to be at higher risk for severe RV disease. However, very little is known about the host immune response to RV infection in PWH. Here, we investigated gene expression changes in the peripheral blood of PWH co-infected with RV. Only very few differentially expressed genes could be detected between PWH with and without RV infection, suggesting that the immune response to RV in PWH is strongly dampened. Our data provides important insights into the host response to RV infections in HIV patients.
format	article
author	Subhashini A. Sellers William A. Fischer Mark T. Heise Klaus Schughart
author_facet	Subhashini A. Sellers William A. Fischer Mark T. Heise Klaus Schughart
author_sort	Subhashini A. Sellers
title	Highly dampened blood transcriptome response in HIV patients after influenza infection
title_short	Highly dampened blood transcriptome response in HIV patients after influenza infection
title_full	Highly dampened blood transcriptome response in HIV patients after influenza infection
title_fullStr	Highly dampened blood transcriptome response in HIV patients after influenza infection
title_full_unstemmed	Highly dampened blood transcriptome response in HIV patients after influenza infection
title_sort	highly dampened blood transcriptome response in hiv patients after influenza infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/99258aa0f02e4fc18694a57eb7cb7a30
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Highly dampened blood transcriptome response in HIV patients after influenza infection

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